Chronic Hyperkaliemia in Chronic Kidney Disease: An Old Concern with New Answers

Increasing potassium intake ameliorates blood pressure (BP) and cardiovascular (CV) prognoses in the general population; therefore the World Health Organization recommends a high-potassium diet (90–120 mEq/day). Hyperkalaemia is a rare condition in healthy individuals due to the ability of the kidneys to effectively excrete dietary potassium load in urine, while an increase in serum K⁺ is prevalent in patients with chronic kidney disease (CKD). Hyperkalaemia prevalence increases in more advanced CKD stages, and is associated with a poor prognosis. This scenario generates controversy on the correct nutritional approach to hyperkalaemia in CKD patients, considering the unproven link between potassium intake and serum K⁺ levels. Another concern is that drug-induced hyperkalaemia leads to the down-titration or withdrawal of renin-angiotensin system inhibitors (RASI) and mineralocorticoids receptors antagonists (MRA) in patients with CKD, depriving these patients of central therapeutic interventions aimed at delaying CKD progression and decreasing CV mortality. The new K⁺-binder drugs (Patiromer and Sodium-Zirconium Cyclosilicate) have proven to be adequate and safe therapeutic options to control serum K⁺ in CKD patients, enabling RASI and MRA therapy, and possibly, a more liberal intake of fruit and vegetables.     

Modeling Lung Carcinoids with Zebrafish Tumor Xenograft

Lung carcinoids are neuroendocrine tumors that comprise well-differentiated typical (TCs) and atypical carcinoids (ACs). Preclinical models are indispensable for cancer drug screening since current therapies for advanced carcinoids are not curative. We aimed to develop a novel in vivo model of lung carcinoids based on the xenograft of lung TC (NCI-H835, UMC-11, and NCI-H727) and AC (NCI-H720) cell lines and patient-derived cell cultures in Tg(fli1a:EGFP)^y1 zebrafish embryos. We exploited this platform to test the anti-tumor activity of sulfatinib. The tumorigenic potential of TC and AC implanted cells was evaluated by the quantification of tumor-induced angiogenesis and tumor cell migration as early as 24 h post-injection (hpi). The characterization of tumor-induced angiogenesis was performed in vivo and in real time, coupling the tumor xenograft with selective plane illumination microscopy on implanted zebrafish embryos. TC-implanted cells displayed a higher pro-angiogenic potential compared to AC cells, which inversely showed a relevant migratory behavior within 48 hpi. Sulfatinib inhibited tumor-induced angiogenesis, without affecting tumor cell spread in both TC and AC implanted embryos. In conclusion, zebrafish embryos implanted with TC and AC cells faithfully recapitulate the tumor behavior of human lung carcinoids and appear to be a promising platform for drug screening.     

The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility

Varicocele (VC) is the most common abnormality identified in men evaluated for hypofertility. Increased levels of reactive oxygen species (ROS) and reduced antioxidants concentrations are key contributors in varicocele-mediated hypofertility. Moreover, inflammation and alterations in testicular immunity negatively impact male fertility. In particular, NLRP3 inflammasome activation was hypothesized to lead to seminal inflammation, in which the levels of specific cytokines, such as IL-1β and IL-18, are overexpressed. In this review, we described the role played by oxidative stress (OS), inflammation, and NLRP3 inflammasome activation in VC disease. The consequences of ROS overproduction in testis, including inflammation, lipid peroxidation, mitochondrial dysfunction, chromatin damage, and sperm DNA fragmentation, leading to abnormal testicular function and failed spermatogenesis, were highlighted. Finally, we described some therapeutic antioxidant strategies, with recognized beneficial effects in counteracting OS and inflammation in testes, as possible therapeutic drugs against varicocele-mediated hypofertility.     

呼吸房子——现代沙特房屋

项目地点:沙特阿拉伯利雅得项目类型:建筑(住宅)开工日期:未知该项目获2005年豪瑞可持续建筑大奖赛非洲中东地区提名奖     

Edge degree-of-sharpness and free-stream turbulence scale effects on the aerodynamics of a bridge deck

This paper discusses the sensitivity of the aerodynamic behavior of a trapezoidal-shaped bridge deck cross-section to its lower corner degree-of-sharpness and to the incoming flow turbulence integral length scale in conjunction with low turbulence intensity. Since these features are hard to set and measure in experimental facilities, the aerodynamic behavior of the body has been investigated through the computational simulation of the flow around it. The results are given in term of force coefficients, Strouhal number, pressure distribution along its surface, and the mean and instantaneous flow patterns. Dramatic changes in the force coefficients and Strouhal number occur following small changes in the parameter values. These changes have been found to be due to significant modifications in the topological structure of the flow. Special emphasis has been given to the analysis of the separation and reattachment points, the recirculation bubble length, the vortex shedding mechanisms and the wake structures. On the basis of the results, four aerodynamic regimes have been pointed out in analogy with the well-known individual Re number regimes. Some of these regimes have also been recognized on the deck section with the considered sharpest and smoothest lower edge treatments, i.e. for the highest and lowest degrees-of-sharpness.     

Transition‐Metal Dichalcogenide NiTe2: An Ambient‐Stable Material for Catalysis and Nanoelectronics

By means of theory and experiments, the application capability of nickel ditelluride (NiTe₂) transition‐metal dichalcogenide in catalysis and nanoelectronics is assessed. The Te surface termination forms a TeO₂ skin in an oxygen environment. In ambient atmosphere, passivation is achieved in less than 30 min with the TeO₂ skin having a thickness of about 7 Å. NiTe₂ shows outstanding tolerance to CO exposure and stability in water environment, with subsequent good performance in both hydrogen and oxygen evolution reactions. NiTe₂‐based devices consistently demonstrate superb ambient stability over a timescale as long as one month. Specifically, NiTe₂ has been implemented in a device that exhibits both superior performance and environmental stability at frequencies above 40 GHz, with possible applications as a receiver beyond the cutoff frequency of a nanotransistor.     

A New Modulation for Intrinsically Secure Radio Channel in Wireless Systems

One of the biggest challenges in RFID (radio frequency identification) large scale deployment, such as in warehouse RFID deployment, is the positioning of RFID reader antennas to efficiently locate all the tagged objects distributed at RFID reader environment. This paper has investigated a novel location sensing system based on geometric grid covering algorithm that can use any passive or active RFID standard for positioning or tracking objects inside buildings. This study involves design of RFID reader antenna network which focuses on placing the reader antennas on a grid to cover all the tags distributed at two dimensional planes and position calculation using statistical averages algorithm. The statistical averages algorithm simply computes the location coordinates of the tagged object by statistical average of the reader antenna’s location. The proposed grid of reader antennas can assist in minimizing the actual number of reader antennas required for RFID large scale deployment. The proposed prototype system is a simpler positioning system which presents the solution of placement pattern of RFID reader antennas, gives less complicated mathematical calculation, and is able to provide a high degree of accuracy. The obtained results show that the proposed location sensing system can achieve better positioning accuracy as compared to existing positioning system and in some cases accuracy improvement of about 50% can be reached.

Modeling of program, erase and retention characteristics of charge-trap gate all around memories

This paper describes the effect of geometry in charge-trap (CT) memory devices. We first theoretically analyze the impact of the curvature radius on the behavior of the gate current in Gate-All-Around devices, and then describe the change to make to planar model in order to fit the cylindrical devices characteristics. This model is used to simulate Nanocrystal and SONOS program, erase and retention behaviors. The dynamics enhancement during program/erase due to the bending of the active region in such cylindrical devices is explained. The scaling perspectives conclude this paper.     

An improved BEM model for the power curve prediction of stall‐regulated wind turbines

Blade element momentum (BEM) theory is the standard computational technique for the prediction of power curves of wind turbines; it is based on the two‐dimensional aerodynamic properties of aerofoil blade elements and some corrections accounting for three‐dimensional wing aerodynamics. Although most BEM models yield acceptable results for low‐wind and pitch‐controlled regimes where the local angles of attack are small, no generally accepted model exists up to date that consistently predicts the power curve in the stall regime for a variety of blade properties and operating conditions. In this article we present a modified BEM model which satisfactorily reproduces the power curves of four experimental wind turbines reported in the literature, using no free fit parameters. Since these four experimental cases comprehend a great variety of conditions (wind tunnel vs field experiments, different air densities) and blade parameters (no twist and no taper, no taper but twist, both twist and taper, different aerofoil families), it is believed that our model represents a useful working tool for the aerodynamic design of stall‐regulated wind turbines. Copyright © 2004 John Wiley & Sons, Ltd.     

Game theory and time utility functions for a radio aware scheduling algorithm for WiMAX networks

In WiMAX systems the Base Station scheduler plays a key role as it controls the sharing of the radio resources among the users. The goal of the scheduler is multiple: achieve fair usage of the resources, satisfy the QoS requirements of the users, maximize goodput, and minimize power consumption, and at the same time ensuring feasible algorithm complexity and system scalability. Since most of these goals are contrasting, scheduler designers usually focus their attention on optimizing one aspect only. In this scenario, we propose a scheduling algorithm (called GTS_Nmathrm{GTS_N}) whose goal is to contemporaneously achieve efficiency and fairness, while also taking into account the QoS requirements and the channel state. GTS_Nmathrm{GTS_N} exploits the properties of Time Utility Functions (TUFs) and Game Theory. Simulations prove that the performance of GTS_N,mathrm{GTS_N}, when compared to that of several well-known schedulers, is remarkable. GTS_Nmathrm{GTS_N} provides the best compromise between the two contrasting objectives of fairness and efficiency, while QoS requirements are in most cases guaranteed. However, the exponential complexity introduced by the game theory technique makes it rather impractical and not computationally scalable for a large number of users. Thus we developed a suboptimal version, named sub-GTS_N.mathrm{GTS_N}. We show that this version retains most of the features and performance figures of its brother, but its complexity is linear with the number of users.