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排序方式: 共有1453条查询结果,搜索用时 15 毫秒
31.
de Oliveira Amanda Gerhardt Moreno Janaina Fernandes de Sousa Ana Maria Furtado Esccio Viviane Alves de Oliveira Cavalcanti Guimares Maria Jos da Silva Ana Lucia Nazareth 《Polymer Bulletin》2020,77(6):2889-2904
Polymer Bulletin - Investigating the compatibility mechanism of hybrid composites based on two polymers and one mineral nanofiller is a challenge that needs to be better understood. This study... 相似文献
32.
It is shown that peroxidation of phosphatidylcholine (PC) is enhanced in liver of mice fed a hepatocarcinogenic choline-deficient
diet containing 0.1% w/w ethionine. Mice were divided into 4 groups and fed for 3 weeks one of the following diets: choline-supplemented;
choline-supplemented containing ethionine; choline-deficient; and choline-deficient containing ethionine. Phosphatidylcholine
hydroperoxide (PCOOH) of liver lipids was measured by high performance liquid chromatography using a chemiluminescence detector.
Mice fed a choline-deficient diet containing ethionine showed 6-fold higher PCOOH levels than the choline-supplemented control
mice: the PCOOH/PC molar ratios of liver lipids were 32.3×10−5 and 5.6×10−5, respectively. In addition to this remarkable degree of lipid peroxidation in liver of mice fed the choline-deficient diet
containing ethionine, we also observed a significant liver fatty infiltration, a decrease in plasma and liver α-tocopherol,
and an increase in liver injury-indicative enzyme activities. Also, marker enzymes for hepatocarcinogenesis, glucose-6-phosphatase
and γ-glutamyl transpeptidase were affected. These data suggest that enhanced hydroperoxidation of phosphatidylcholine may
participate in hepatocarcinogenesis provoked by choline deficiency in the presence of ethionine. 相似文献
33.
Maria Lisa Garavaglia Daniela Giustarini Graziano Colombo Francesco Reggiani Silvia Finazzi Marta Calatroni Lucia Landoni Nicola Marcello Portinaro Aldo Milzani Salvatore Badalamenti Ranieri Rossi Isabella Dalle-Donne 《International journal of molecular sciences》2022,23(5)
Thiols (sulfhydryl groups) are effective antioxidants that can preserve the correct structure of proteins, and can protect cells and tissues from damage induced by oxidative stress. Abnormal levels of thiols have been measured in the blood of patients with moderate-to-severe chronic kidney disease (CKD) compared to healthy subjects, as well as in end-stage renal disease (ESRD) patients on haemodialysis or peritoneal dialysis. The levels of protein thiols (a measure of the endogenous antioxidant capacity inversely related to protein oxidation) and S-thiolated proteins (mixed disulphides of protein thiols and low molecular mass thiols), and the protein thiolation index (the molar ratio of the S-thiolated proteins to free protein thiols in plasma) have been investigated in the plasma or red blood cells of CKD and ESRD patients as possible biomarkers of oxidative stress. This type of minimally invasive analysis provides valuable information on the redox status of the less-easily accessible tissues and organs, and of the whole organism. This review provides an overview of reversible modifications in protein thiols in the setting of CKD and renal replacement therapy. The evidence suggests that protein thiols, S-thiolated proteins, and the protein thiolation index are promising biomarkers of reversible oxidative stress that could be included in the routine monitoring of CKD and ESRD patients. 相似文献
34.
Angelo G. Giumanini Giancarlo Verardo Ennio Zangrando Lucia Lassiani 《Advanced Synthesis \u0026amp; Catalysis》1987,329(6):1087-1103
A product study of the reaction between a number of aromatic amines substituted with widely different groups and paraformaldehyde in inert solvents was performed and found to yield 1,3,5-triaryl-1,3,5-hexahydrotriazines, 1,3,5,7-tetraaryl-1,3,5,7-tetrazocines and formaminals. It was not possible to correlate the product outcomes with the actual structure of the amine substrate. The X-ray diffraction structural determination of 1,3,5-tri-(t-butylphenyl)-( 1b ) and 1,3,5-tri-(m-fluorophenyl)-1,3,5-hexahydrotriazine ( 1c ) showed the diaxial arrangement of the N-substituents. 相似文献
35.
Francesco Borgia Lucia Peterle Paolo Custurone Mario Vaccaro Giovanni Pioggia Sebastiano Gangemi 《International journal of molecular sciences》2022,23(6)
Acne Vulgaris (AV) and Hidradenitis suppurativa (HS) are common chronic inflammatory skin conditions that affect the follicular units that often coexist or are involved in differential diagnoses. Inflammation in both these diseases may result from shared pathways, which may partially explain their frequent coexistence. MicroRNAs (miRNAs) are a class of endogenous, short, non-protein coding, gene-silencing or promoting RNAs that may promote various inflammatory diseases. This narrative review investigates the current knowledge regarding miRNAs and their link to AV and HS. The aim is to examine the role of these molecules in the pathogenesis of AV and HS and to identify possible common miRNAs that could explain the similar characteristics of these two diseases. Five miRNA (miR-155 miR-223-, miR-21, and miRNA-146a) levels were found to be altered in both HS and AV. These miRNAs are related to pathogenetic aspects common to both pathologies, such as the regulation of the innate immune response, regulation of the Th1/Th17 axis, and fibrosis processes that induce scar formation. This review provides a starting point for further studies aimed at investigating the role of miRNAs in AV and HS for their possible use as diagnostic-therapeutic targets. 相似文献
36.
Hossam M. Zawbaa Serena Schiano Lucia Perez-Gandarillas Crina Grosan A. Michrafy Chuan-Yu Wu 《Advanced Powder Technology》2018,29(12):2966-2977
In pharmaceutical development, it is very useful to exploit the knowledge of the causal relationship between product quality and critical material attributes (CMA) in developing new formulations and products, and optimizing manufacturing processes. With the big data captured in the pharmaceutical industry, computational intelligence (CI) models could potentially be used to identify critical quality attributes (CQA), CMA and critical process parameters (CPP). The objective of this study was to develop computational intelligence models for pharmaceutical tabletting processes, for which bio-inspired feature selection algorithms were developed and implemented for optimisation while artificial neural network (ANN) was employed to predict the tablet characteristics such as porosity and tensile strength. Various pharmaceutical excipients (MCC PH 101, MCC PH 102, MCC DG, Mannitol Pearlitol 200SD, Lactose, and binary mixtures) were considered. Granules were also produced with dry granulation using roll compaction. The feed powders and granules were then compressed at various compression pressures to produce tablets with different porosities, and the corresponding tensile strengths were measured. For the CI modelling, the efficiency of seven bio-inspired optimization algorithms were explored: grey wolf optimization (GWO), bat optimization (BAT), cuckoo search (CS), flower pollination algorithm (FPA), genetic algorithm (GA), particle swarm optimization (PSO), and social spider optimization (SSO). Two-thirds of the experimental dataset was randomly chosen as the training set, and the remaining was used to validate the model prediction. The model efficiency was evaluated in terms of the average reduction (representing the fraction of selected input variables) and the mean square error (MSE). It was found that the CI models can well predict the tablet characteristics (i.e. porosity and tensile strength). It was also shown that the GWO algorithm was the most accurate in predicting porosity. While the most accurate prediction for the tensile strength was achieved using the SSO algorithm. In terms of the average reduction, the GA algorithm resulted in the highest reduction of inputs (i.e. 60%) for predicting both the porosity and the tensile strength. 相似文献
37.
Priyalal Wijewarnasuriya Yuanping Chen Greg Brill Nibir Dhar David Benson Lucia Bubulac Dennis Edwall 《Journal of Electronic Materials》2010,39(7):1110-1117
We have performed a detailed study of dark current versus voltage to understand existing limitations in dark current and address
the nonuniformity of dark current in devices fabricated on HgCdTe grown on silicon substrates. One interesting observation
is that trap-assisted tunneling, g-r currents, are not found close to zero bias in certain devices. Devices from the low end
of the R
0
A distribution show heavy shunting paths close to zero bias. We believe that these shunting paths may be the limiting cause
of tail distributions in fabricated focal plane array tail distributions. Possible causes for these shunting paths are surface
charges associated with dislocation cores and impurity gettering at dislocation cores. The measured non-anti-reflection (AR)-coated
quantum efficiency (QE) was 0.576 at 78 K and displays the classical response versus wavelength. The measured QE on isolated
single devices is consistent with the 256 × 256 focal-plane array mean QE. Obtained average dark currents are on the order
of mid 10−5 A cm–2, which is one order of magnitude higher than dark currents obtained from arrays on lattice-matched substrates. On average,
arrays on lattice-mismatched substrates show performance characteristics inferior to those of arrays fabricated on lattice-matched
substrates. This inferior performance is due to array pixel operability, as can be seen from the tail of the distribution
and the average dark currents, which are one order of magnitude higher than those obtained on lattice-matched substrates. 相似文献
38.
A Ravasio M Pasquinelli B Currò Dossi W Neri C Guidi M Gessaroli F Rasi R Fabbri G Mazzini GG Rebucci 《Canadian Metallurgical Quarterly》1995,16(7):487-492
We report the effects of treatment with plasma-exchange (PE) and intravenous immune globulins (IVIg) in 36 out of 50 patients with Guillain-Barré syndrome (GBS) recruited by an incidence study in the Emilia-Romagna region of Italy. Comparison of the patients treated with PE and IVIg showed no significant differences in terms of effectiveness in improving the clinical course of GBS: at one month, respectively 11.1% and 25% had recovered, and 55.5% and 58.3% had improved by at least one grade. These results are in agreement with those of the Dutch GBS trial. No relapses were observed in either group. Moreover, our results showed no difference in clinical outcome at 1 and 3 months between the patients receiving only one therapy and those receiving two; a second cycle of therapy did not seem to improve the clinical course of the disease significantly. We conclude that PE and IVIg are both safe and effective therapies for GBS. 相似文献
39.
Aquilanti L Garofalo C Osimani A Silvestri G Vignaroli C Clementi F 《Journal of food protection》2007,70(3):557-565
The transfer via the food chain from animals to humans of microbes that are resistant to antimicrobial agents is of increasing concern. To determine the contributions of nonpathogenic microflora to the occurrence and spread of antibiotic resistance (AR) genes in the food chain, 123 lactic acid bacteria were isolated from 29 samples of raw and processed pork and chicken meat products that had previously tested positive for one or more AR genes that encode clinically relevant ARs: tet(M), tet(O), tet(K), erm(A), erm(B), erm(C), aac (6')-Ie aph (2")-Ia, mecA, and blaZ. All of the isolates were initially tested for their AR gene profiles by PCR. The 59 isolates carrying a tet, erm, or blaZ gene were taken through molecular identification, analyzed by determination of the MIC, and subjected to genetic fingerprinting. Lactococcus garvieae was the predominant species (28 isolates), followed by Lactobacillus plantarum (11 isolates) and L. salivarius (6 isolates), whereas Lactococcus lactis subsp. lactis, Lactobacillus johnsonii, L. reuteri, L. crispatus, and L. brevis were identified at lower frequencies. The tet(M) and erm(B) genes were the most frequently detected. Assessment of multiple resistances in 18 tet positive (tet+) isolates revealed that tet(M) plus erm(B) and tet(K) plus erm(B) were the most frequent AR gene patterns. Partial sequencing of the tet(M) open reading frame of three selected strains showed high sequence similarities (> 99%) with tet(M) genes previously found in human pathogens (Listeria monocytogenes and Neisseria meningitidis). Southern hybridization with plasmid profiles revealed these strains contained tet(M)-carrying plasmids. 相似文献
40.
Mario Gleria Francesco Minto Lucia Flamigni Pietro Bortolus 《Journal of Inorganic and Organometallic Polymers》1992,2(3):329-344
The synthesis and photochemical behavior both in solution and in the solid state of poly[bis(4-isopropylphenoxy)0.8 (4-benzoylphenoxy)1.2 phosphazene] is described. The main reaction of this material under illumination with light of a wavelength longer than 340 nm is the intramolecular abstraction of an hydrogen atom by the excited benzophenone substituent from the 4-isopropylphenoxy moiety geminally substituted on the same phosphorus of the phosphazene chain. In this way highly reactive radical species are produced which induce very efficient photo-cross-linking of the phosphazene copolymer and insolubilization. The efficiency of this process in the solid state is examined in view of the potential application of this material as a polyphosphazene-based negative photoresist. 相似文献