The association of leukocytes with secondary brain injury

Shock increases mortality from brain injuries, but the mechanism is poorly understood. We hypothesized that brain injury followed by shock and resuscitation leads to a secondary reperfusion injury mediated in part by polymorphonuclear leukocytes (PMNs). To validate this hypothesis, we studied cerebral perfusion pressure (CPP), intracranial pressure (ICP), cerebral blood flow (CBF), cortical water content (CWC), and hemodynamic variables in a porcine model of focal cryogenic brain injury and hemorrhagic shock. Cerebral PMN accumulation (CPMN) in the injured and uninjured hemispheres was determined histologically from the total PMNs in five high-power fields (400x). Twenty-nine mature swine were randomized to four groups. Group 1, the control group, was instrumented only. Group 2 animals had a brain injury alone and were studied for 24 hours. Group 3 animals had a brain injury and hemorrhagic shock. Group 4 animals had hemorrhagic shock alone. Brain injury followed by shock caused a significantly greater ICP and a significantly lower CBF than brain injury or shock alone. There was no significant difference in CPP between groups after resuscitation. The CWC of the lesioned area was similar in both brain-injured groups but was significantly increased when compared with the controls and the shock-only group. The CWC of the nonlesioned hemisphere was higher in group 3 than in group 2. The CPMN in both hemispheres in group 3 was significantly greater than in either group 2 or group 4. There was a significant positive correlation between CPMN and both ICP and CWC, and a significant negative correlation between CPMN and CBF. These data suggest an association between CPMN accumulation and secondary brain injury.     

6M32(51)氮氢气压缩机系统的技术改造

1 机组简介 6M32(51)-190/320-BX型氮氢气压缩机的基础件采用德国博尔格公司的专有技术,具体参数如下: 压缩介质:氮氢气,压缩级数:6级;转速:375rpm;行程:320mm,轴功率:2920kW,容积流量:190m~3/min;气量调节:回路调节,冷却填料润滑油:1.95 kg/h;重量:主机69.45t,     

FINITE ELEMENT ANALYSIS OF THE FLOW INDUCED BY ROTATING BLADES IN AN INCOMPRESSIBLE VISCOUS FLUID

Aerodynamic loads on a multi-bladed helicopter rotor in hovering flight were calculated by solving the three-dimensional incompressible Navier-Stokes equations. The rotor wake effects were accounted by the correction of local geometric angle of attack according to a free-wake modeling in addition to an empirical modification for the tip flow effect. The validity and efficiency of the present method were verified by the comparisons between numerical results and experimental data.     

Synthesis of Nearly Monodisperse Iron Oxide and Oxyhydroxide Nanocrystals

Uniform magnetite, hematite, and goethite nanocrystals were prepared through an attractive method based on an oleic acid/alcohol/water system. By adjusting the synthetic parameters (base concentration, alcohol content, categories of alcohols, etc.), the controlled synthesis of uniform magnetite, hematite, and goethite nanocrystals can be easily achieved. Detailed investigations on the effect of the experimental parameters on the morphology of the final products and the phase transitions among the magnetite, hematite, and goethite phases were carried out. Finally, a method of doping other metal ions into magnetite was developed and the magnetic properties of magnetite doped with different metal elements were studied.     

布正伟新作八人谈——思想与创作共舞：读《创作视界论》谈布正伟先生

作为在高等院校设计院工作的一名建筑师．除埋头设计外，我对理论问题有相当的偏好．这种偏好又带有很强的实用主义色彩。尤其对那些既有精妙设计．又有睿智思想的建筑师很是崇拜．这当然包括设计作品和理论专著文章。而且每每喜欢将作品与理论文章对照着来读，字里行间仿佛看到一个个作品跃然纸上．而实际工程又仿佛在叙述着作者的思想．这种读法令我了解了许多建筑师。然而不难发现．     

用最小二乘法恢复逐行倒相副载波

介绍ＰＡＬ制彩色全电视信号中色同步信号编码原理及恢复逐行倒相副载波的过程中，两种计算色同步信号相位角的方法。并且在实验的基础上得出：最小二乘法在ＰＡＬ制电视信号的副载波相位角计算中不仅可以满足精度要求，而且简便灵活。     

Optic flow field segmentation and motion estimation using a robustgenetic partitioning algorithm

Optic flow motion analysis represents an important family of visual information processing techniques in computer vision. Segmenting an optic flow field into coherent motion groups and estimating each underlying motion is a very challenging task when the optic flow field is projected from a scene of several independently moving objects. The problem is further complicated if the optic flow data are noisy and partially incorrect. In this paper, the authors present a novel framework for determining such optic flow fields by combining the conventional robust estimation with a modified genetic algorithm. The baseline model used in the development is a linear optic flow motion algorithm due to its computational simplicity. The statistical properties of the generalized linear regression (GLR) model are thoroughly explored and the sensitivity of the motion estimates toward data noise is quantitatively established. Conventional robust estimators are then incorporated into the linear regression model to suppress a small percentage of gross data errors or outliers. However, segmenting an optic flow field consisting of a large portion of incorrect data or multiple motion groups requires a very high robustness that is unattainable by the conventional robust estimators. To solve this problem, the authors propose a genetic partitioning algorithm that elegantly combines the robust estimation with the genetic algorithm by a bridging genetic operator called self-adaptation     

Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas

Carcinoma in ulcerative colitis (UC) develops from dysplastic precursor lesions, which include flat dysplasia (FD) and polypoid dysplasias (PD). PD may present as single or multiple polypoid structures or as plaque-like lesions that, independent of histological grade, are an indication for colectomy. PDs are histologically similar to adenomas and may not be readily distinguished by light microscopy. It is not known whether FD and PD are different entities, or whether they represent etiologically similar lesions with different morphological expression. We microdissected 25 cases of UC with PD and 19 samples of FD with surrounding chronic colitis (CC) in UC. Loss of heterozygosity (LOH) at the von Hippel Lindau (vHL) gene locus and the putative tumor suppressor genes APC, INK4A (9p16), and p53 was studied. LOH of the vHL gene, INK4A (9p16), and APC was also studied in 11 sporadic adenomas of the colon. LOH at the vHL locus was present in 50% of the samples of PD and in 12% of the samples of FD. LOH was seen in CC close to PD and FD in 26% and 12% of cases, respectively. No adenoma showed LOH of the vHL gene markers studied. LOH in p53 was seen in PD in 16% cases and in FD in 42% cases and in CC close to PD and FD in 0% and 14% cases, respectively. LOH patterns between PD and FD of the markers for APC and 9p16 were not different. LOH in APC was seen in two of five cases of adenoma. We conclude that PD and FD share genetic alterations in APC and 9p16 genes. More frequent involvement of the VHL gene in PD and surrounding CC and involvement of p53 in HGD and CC in FD may represent genetic differences between the development of PD and FD and may be the cause of the different morphology. The infrequency of LOH at the vHL locus in adenomas versus PD may serve as a discriminator between adenomas and PD in diagnostically problematic cases.     

基于SAP接口技术的移动终端解决方案

越来越多的企业正在或者即将用SAP作为ERP的应用载体。企业在得益于ERP精细化管理的同时,往往也为ERP与其他子系统整合集成所烦恼。介绍了几种应用于SAP的接口技术,其中包括RFC、ALE-IDOC、BAPI、SAP-DCOM以及Web Service接口技术。并且在此基础上,列举了企业内部的一个实例,展现了SAP通过接口技术与外部的PDA移动终端系统整合,从而解决了维修服务行业从接收工单、记录维修、备件管理等在移动环境下的应用需求。     

Modeling polypharmacy effects with heterogeneous signed graph convolutional networks

Applied Intelligence - Pharmaceutical drug combinations can effectively treat various medical conditions. However, some combinations can cause serious adverse drug reactions (ADR). Therefore,...