Assisted living solutions for the elderly through interactive TV

In this paper we present an application called Med-reminder, which extends the functionality of existing devices providing interactive TV and helps to increase the quality of life for the elderly. The Med-reminder application is used to remind people to take their medicines correctly and on time or to call a relative or a medical person in an emergency situation. Since the graphical user interface was adapted for the elderly, Med-reminder is easy to use without previous training. For evaluating the graphical user interface, navigation and the general usability of the application, and hence the identification of key aspects that increase the adoption rate of assisted living applications among the target population, a methodology for a user evaluation study was designed and conducted. User evaluation study results are presented in the paper.     

Assessment of Methods Used in 1D Models for Computing Bed-Load Transport in a Large River: The Danube River in Slovakia

Comprehensive measurements of bed-load sediment transport through a section of the Danube River, located approximately 70?km downstream from Bratislava, Slovakia, are used to assess the accuracy of bed-load formulas implemented in 1D modeling. Depending on water discharge and water level, significant variations in the distribution of bed load across the section were observed. It appeared that, whatever the water discharge, the bed shear stress τ is always close to the estimated critical bed shear stress for the initiation of sediment transport τcr. The discussion focuses on the methods used in 1D models for estimating bed-load transport. Though usually done, the evaluation of bed-load transport using the mean cross-sectional bed shear stress yields unsatisfactory results. It is necessary to use an additional model to distribute the bed shear stress across the section and calculate bed load locally. Bed-load predictors also need to be accurate for τ close to τcr. From that point of view, bed-load formulas based on an exponential decrease of bed-load transport close to τcr appear to be more appropriate than models based on excess bed shear stress. A discussion on the bed-load formula capability to reproduce grain sorting is also provided.     

Electrical and structural characterization of inhomogeneously doped semiconductors by infrared spectroscopy

An optical method is presented for thenon-destructive electrical and structural characterisation of multilayer structures. The presented concept yields the complex refractive index profiles within an arbitrary composed layer system by using the symmetrical transmission and the asymmetrical reflectivity caused by the optical inhomogeneity of a material. This method includes the superimposition of coherent multiple reflections within the refractive index profile as well as incoherent multiple reflections within the whole wafer. This analysis yields the spacial distribution of free carrier density profiles within the sample as well as the transitions between different crystal phases by using the least squares fit procedures. The results of the optical analysis are compared with other methods used to quantitatively determine density profiles and phase transitions such as SIMS, spreading resistance, stripping Hall and RBS.     

Green tea catechins of food supplements facilitate pepsin digestion of major food allergens,but hampers their digestion if oxidized by phenol oxidase

The in vitro gastric digestion of several food allergens (beta-lactoglobulin (BLG), alpha-lactalbumin (LA) and peanut allergens (PE)) in the presence of a catechin-enriched polyphenol extract of green tea (GTC), oxidized polyphenols and phenol oxidase processed food allergens and GTC was investigated. Pepsin-resistant proteins, such as BLG, major peanut allergens, Ara h 1 and Ara h 2, degrade faster in the presence of catechin-enriched green tea polyphenols. Phenol oxidase polymerized GTC affected adversely protein digestion of BLG and LA, but not digestion of PE proteins. Protecting effect of polyphenols correlated well with the ability of proteins to form insoluble complexes with oxidized catechins. Cross-linking of proteins and polyphenols further extended the half-lives of BLG and LA in the in vitro digestion by pepsin. Catechin-enriched green tea polyphenols of food supplements facilitate pepsin digestion of major food allergens, but hamper their digestion if oxidized and polymerized by phenol oxidase.     

Supramolecular Chemistry of Carbon-Based Dots Offers Widespread Opportunities

Carbon dots are an emerging class of nanomaterials that has recently attracted considerable attention for applications that span from biomedicine to energy. These photoluminescent carbon nanoparticles are defined by characteristic sizes of <10 nm, a carbon-based core and various functional groups at their surface. Although the surface groups are widely used to establish non-covalent bonds (through electrostatic interactions, coordinative bonds, and hydrogen bonds) with various other (bio)molecules and polymers, the carbonaceous core could also establish non-covalent bonds (π π stacking or hydrophobic interactions) with π-extended or apolar compounds. The surface functional groups, in addition, can be modified by various post-synthetic chemical procedures to fine-tune the supramolecular interactions. Our contribution categorizes and analyzes the interactions that are commonly used to engineer carbon dots-based materials and discusses how they have allowed preparation of functional assemblies and architectures used for sensing, (bio)imaging, therapeutic applications, catalysis, and devices. Using non-covalent interactions as a bottom-up approach to prepare carbon dots-based assemblies and composites can exploit the unique features of supramolecular chemistry, which include adaptability, tunability, and stimuli-responsiveness due to the dynamic nature of the non-covalent interactions. It is expected that focusing on the various supramolecular possibilities will influence the future development of this class of nanomaterials.     

Differential Expression of Serum Extracellular Vesicle miRNAs in Multiple Sclerosis: Disease-Stage Specificity and Relevance to Pathophysiology

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). Its first clinical presentation (clinically isolated syndrome, CIS) is often followed by the development of relapsing–remitting MS (RRMS). The periphery-to-CNS transmission of inflammatory molecules is a major pathophysiological pathway in MS. This could include signalling via extracellular vesicle (EV) microRNAs (miRNAs). In this study, we investigated the serum EV miRNome in CIS and RRMS patients and matched controls, with the aims to identify MS stage-specific differentially expressed miRNAs and investigate their biomarker potential and pathophysiological relevance. miRNA sequencing was conducted on serum EVs from CIS-remission, RRMS-relapse, and viral inflammatory CNS disorder patients, as well as from healthy and hospitalized controls. Differential expression analysis was conducted, followed by predictive power and target-pathway analysis. A moderate number of dysregulated serum EV miRNAs were identified in CIS-remission and RRMS-relapse patients, especially relative to healthy controls. Some of these miRNAs were also differentially expressed between the two MS stages and had biomarker potential for patient-control and CIS–RRMS separations. For the mRNA targets of the RRMS-relapse-specific EV miRNAs, biological processes inherent to MS pathophysiology were identified using in silico analysis. Study findings demonstrate that specific serum EV miRNAs have MS stage-specific biomarker potential and contribute to the identification of potential targets for novel, efficacious therapies.