全文获取类型
收费全文 | 177篇 |
免费 | 11篇 |
专业分类
电工技术 | 2篇 |
综合类 | 1篇 |
化学工业 | 68篇 |
金属工艺 | 12篇 |
机械仪表 | 1篇 |
建筑科学 | 6篇 |
矿业工程 | 1篇 |
能源动力 | 3篇 |
轻工业 | 3篇 |
无线电 | 12篇 |
一般工业技术 | 33篇 |
冶金工业 | 7篇 |
原子能技术 | 2篇 |
自动化技术 | 37篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 8篇 |
2021年 | 20篇 |
2020年 | 3篇 |
2019年 | 6篇 |
2018年 | 6篇 |
2017年 | 7篇 |
2016年 | 12篇 |
2015年 | 8篇 |
2014年 | 14篇 |
2013年 | 12篇 |
2012年 | 14篇 |
2011年 | 21篇 |
2010年 | 10篇 |
2009年 | 9篇 |
2008年 | 5篇 |
2007年 | 10篇 |
2006年 | 7篇 |
2005年 | 4篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
排序方式: 共有188条查询结果,搜索用时 444 毫秒
11.
Moment stability for linear systems with a nonwhite parametric noise is considered. A method of reduction of the study of this stability to the study of stability for large-scale matrices is proposed. Mean square stability diagrams for random harmonic oscillator are presented. 相似文献
12.
Lukasz G. Szafaryn Todd Gamblin Bronis R. de Supinski Kevin Skadron 《Journal of Parallel and Distributed Computing》2013
The increasing computational needs of parallel applications inevitably require portability across parallel architectures, which now include heterogeneous processing resources, such as CPUs and GPUs, and multiple SIMD/SIMT widths. However, the lack of a common parallel programming paradigm that provides predictable, near-optimal performance on each resource leads to the use of low-level frameworks with architecture-specific optimizations, which in turn cause the code base to diverge and makes porting difficult. Our experiences with parallel applications and frameworks lead us to the conclusion that achieving performance portability requires a common set of high-level directives and efficient mapping onto each architecture. 相似文献
13.
Stephen L. Lapointe Lukasz L. Stelinski Terence J. Evens Randall P. Niedz David G. Hall Agenor Mafra-Neto 《Journal of chemical ecology》2009,35(8):896-903
Experimental designs developed to address mixtures are suited ideally to many areas of experimental biology, including pheromone
blend studies, because such designs address the confounding of proportionality and concentration intrinsic to factorial and
one-factor-at-a-time designs. Geometric multivariate designs coupled with response surface modeling allowed us to identify
optimal blends of a two-component pheromone for attraction and trap disruption of the leafminer moth, Phyllocnistis citrella, a major pest in citrus growing areas around the world. Field trials confirmed that the natural 3:1 blend of (Z,Z,E)-7,11,13-hexadecatrienal:(Z,Z)-7,11-hexadecadienal was most effective as an attractant for male moths. However, the response surface generated in mating
orientation trials revealed that the triene component alone was more effective than the natural blend in disrupting trap catch.
Each individual component was effective at disrupting orientation in field trials, but (Z,Z,E)-7,11,13-hexadecatrienal was approximately 13 times more effective, at the same concentration, compared with (Z,Z)-7,11-hexadecadienal alone. In addition, the application of geometric design and response surface modeling to field studies
provided insight into a possible mechanism of mating disruption and supported sensory imbalance as the operating mechanism
for this species. 相似文献
14.
Lukasz Drewniak Robert Stasiuk Witold Uhrynowski Aleksandra Sklodowska 《International journal of molecular sciences》2015,16(7):14409-14427
The purpose of this study was a detailed characterization of Shewanella sp. O23S, a strain involved in arsenic transformation in ancient gold mine waters contaminated with arsenic and other heavy metals. Physiological analysis of Shewanella sp. O23S showed that it is a facultative anaerobe, capable of growth using arsenate, thiosulfate, nitrate, iron or manganite as a terminal electron acceptor, and lactate or citrate as an electron donor. The strain can grow under anaerobic conditions and utilize arsenate in the respiratory process in a broad range of temperatures (10–37 °C), pH (4–8), salinity (0%–2%), and the presence of heavy metals (Cd, Co, Cr, Cu, Mn, Mo, Se, V and Zn). Under reductive conditions this strain can simultaneously use arsenate and thiosulfate as electron acceptors and produce yellow arsenic (III) sulfide (As2S3) precipitate. Simulation of As-removal from water containing arsenate (2.5 mM) and thiosulfate (5 mM) showed 82.5% efficiency after 21 days of incubation at room temperature. Based on the obtained results, we have proposed a model of a microbially mediated system for self-cleaning of mine waters contaminated with arsenic, in which Shewanella sp. O23S is the main driving agent. 相似文献
15.
Argument structures are commonly used to develop and present cases for safety, security and for other properties of systems. Such structures tend to grow excessively, which causes problems with their review and assessment. Two issues are of particular interest: (1) systematic and explicit assessment of the compelling power of an argument, and (2) communication of the result of such an assessment to relevant recipients. The paper presents a solution to these problems. The method of Visual Assessment of Arguments (VAA), being this solution, is based on the Dempster-Shafer theory of evidence applied to the assessment of the strength of arguments, and a visual mechanism of issuing and presenting assessments, supported by the so-called opinion triangle. In the paper we explain theoretical grounding for the method and provide guidance on its application. The results of some validation experiments are also presented. 相似文献
16.
Artur Pinski Alexander Betekhtin Jolanta Kwasniewska Lukasz Chajec Elzbieta Wolny Robert Hasterok 《International journal of molecular sciences》2021,22(14)
As cell wall proteins, the hydroxyproline-rich glycoproteins (HRGPs) take part in plant growth and various developmental processes. To fulfil their functions, HRGPs, extensins (EXTs) in particular, undergo the hydroxylation of proline by the prolyl-4-hydroxylases. The activity of these enzymes can be inhibited with 3,4-dehydro-L-proline (3,4-DHP), which enables its application to reveal the functions of the HRGPs. Thus, to study the involvement of HRGPs in the development of root hairs and roots, we treated seedlings of Brachypodium distachyon with 250 µM, 500 µM, and 750 µM of 3,4-DHP. The histological observations showed that the root epidermis cells and the cortex cells beneath them ruptured. The immunostaining experiments using the JIM20 antibody, which recognizes the EXT epitopes, demonstrated the higher abundance of this epitope in the control compared to the treated samples. The transmission electron microscopy analyses revealed morphological and ultrastructural features that are typical for the vacuolar-type of cell death. Using the TUNEL test (terminal deoxynucleotidyl transferase dUTP nick end labelling), we showed an increase in the number of nuclei with damaged DNA in the roots that had been treated with 3,4-DHP compared to the control. Finally, an analysis of two metacaspases’ gene activity revealed an increase in their expression in the treated roots. Altogether, our results show that inhibiting the prolyl-4-hydroxylases with 3,4-DHP results in a vacuolar-type of cell death in roots, thereby highlighting the important role of HRGPs in root hair development and root growth. 相似文献
17.
Ewelina Bik Lukasz Mateuszuk Jagoda Orleanska Malgorzata Baranska Stefan Chlopicki Katarzyna Majzner 《International journal of molecular sciences》2021,22(5)
Chloroquine (CQ) is an antimalarial drug known to inhibit autophagy flux by impairing autophagosome–lysosome fusion. We hypothesized that autophagy flux altered by CQ has a considerable influence on the lipid composition of endothelial cells. Thus, we investigated endothelial responses induced by CQ on human microvascular endothelial cells (HMEC-1). HMEC-1 cells after CQ exposure were measured using a combined methodology based on label-free Raman and fluorescence imaging. Raman spectroscopy was applied to characterize subtle chemical changes in lipid contents and their distribution in the cells, while the fluorescence staining (LipidTox, LysoTracker and LC3) was used as a reference method. The results showed that CQ was not toxic to endothelial cells and did not result in the endothelial inflammation at concentrations of 1–30 µM. Notwithstanding, it yielded an increased intensity of LipidTox, LysoTracker, and LC3 staining, suggesting changes in the content of neutral lipids, lysosomotropism, and autophagy inhibition, respectively. The CQ-induced endothelial response was associated with lipid accumulation and was characterized by Raman spectroscopy. CQ-induced autophagosome accumulation in the endothelium is featured by a pronounced alteration in the lipid profile, but not in the endothelial inflammation. Raman-based assessment of CQ-induced biochemical changes offers a better understanding of the autophagy mechanism in the endothelial cells. 相似文献
18.
Christian Gorenflo Stephen Lee Lukasz Golab Srinivasan Keshav 《International Journal of Network Management》2020,30(5)
Blockchain technologies are expected to make a significant impact on a variety of industries. However, one issue holding them back is their limited transaction throughput, especially compared to established solutions such as distributed database systems. In this paper, we rearchitect a modern permissioned blockchain system, Hyperledger Fabric, to increase transaction throughput from 3000 to 20 000 transactions per second. We focus on performance bottlenecks beyond the consensus mechanism, and we propose architectural changes that reduce computation and I/O overhead during transaction ordering and validation to greatly improve throughput. Notably, our optimizations are fully plug‐and‐play and do not require any interface changes to Hyperledger Fabric. 相似文献
19.
Xavier Martini Denis S. Willett Emily H. Kuhns Lukasz L. Stelinski 《Journal of chemical ecology》2016,42(5):357-367
Plant pathogens can manipulate the odor of their host; the odor of an infected plant is often attractive to the plant pathogen vector. It has been suggested that this odor-mediated manipulation attracts vectors and may contribute to spread of disease; however, this requires further broad demonstration among vector-pathogen systems. In addition, disruption of this indirect chemical communication between the pathogen and the vector has not been attempted. We present a model that demonstrates how a phytophathogen (Candidatus Liberibacter asiaticus) can increase its spread by indirectly manipulating the behavior of its vector (Asian citrus psyllid, Diaphorina citri Kuwayama). The model indicates that when vectors are attracted to pathogen-infected hosts, the proportion of infected vectors increases, as well as, the proportion of infected hosts. Additionally, the peak of infected host populations occurs earlier as compared with controls. These changes in disease dynamics were more important during scenarios with higher vector mortality. Subsequently, we conducted a series of experiments to disrupt the behavior of the Asian citrus psyllid. To do so, we exposed the vector to methyl salicylate, the major compound released following host infection with the pathogen. We observed that during exposure or after pre-exposure to methyl salicylate, the host preference can be altered; indeed, the Asian citrus psyllids were unable to select infected hosts over uninfected counterparts. We suggest mechanisms to explain these interactions and potential applications of disrupting herbivore host preference with plant volatiles for sustainable management of insect vectors. 相似文献
20.
Ewa Surmiak Katarzyna Magiera-Mularz Bogdan Musielak Damian Muszak Justyna Kocik-Krol Radoslaw Kitel Jacek Plewka Tad A. Holak Lukasz Skalniak 《International journal of molecular sciences》2021,22(21)
Targeting the programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) interaction has become an established strategy for cancer immunotherapy. Although hundreds of small-molecule, peptide, and peptidomimetic inhibitors have been proposed in recent years, only a limited number of drug candidates show good PD-1/PD-L1 blocking activity in cell-based assays. In this article, we compare representative molecules from different classes in terms of their PD-1/PD-L1 dissociation capacity measured by HTRF and in vitro bioactivity determined by the immune checkpoint blockade (ICB) co-culture assay. We point to recent discoveries that underscore important differences in the mechanisms of action of these molecules and also indicate one principal feature that needs to be considered, which is the eventual human PD-L1 specificity. 相似文献