激光熔覆用钴基合金粉末的研究

对激光熔覆用WFLC－11钴基合金粉末的激光熔覆工艺和熔覆层性能进行了研究，获得了WFLC－11钴基合金粉末激光熔覆层厚度与最小比能量关系曲线和熔覆层的组织、高温硬度等性能数据，为选择和使用WFLC－11钴基合金粉末提供了依据。     

采矿爆破地震安全距离与设计参数的应用研究

依据爆破安全规程给出了实际检测资料的处理方法。根据爆破设计和检测数据拟合结果的差异性，讨论了爆破地震安全距离S随设计经验参数K、α值的变化规律和范围，得出K取最大值，α取最小值能够最大限度保证现场建筑物安全的结论。     

北京安河泄洪闸金属结构安全检测与评价

水闸安全运行,会受到水工金属结构安全性状影响.京密引水渠安河泄洪闸已投入运行54年.为保障水闸运行安全,需对其金属结构进行全面的安全检测.文章采用多种检测手段对安河泄洪闸金属结构开展现场检测,对结构病害进行梳理,对金属结构的安全状态进行综合评价,为水闸安全运行提供技术支撑.     

组态王和VB在远程定位中的应用

为了利用组态王6.53接收远程数据功能和VB(Visual Basic)对MapX控件进行二次开发功能,利用DDE(Dynamic Data Exchange)技术,实现了组态王6.53与VB通信,根据组态王通信使用的MODBUS协议格式和GPS(Global Positioning System)数据格式,来提取经纬度信息,以此控制动态图层中的图元,来而实现远程车辆的定位,同时也扩大了监控中心软件的功能。     

Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia

Whilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene (HMOX1) expression is modulated by two polymorphisms in the promoter region: (GT)n-length polymorphism and single-nucleotide polymorphism (SNP) A(−413)T, with short GT repeat sequences and 413-A variants linked to an increased HO-1 inducibility. We found that the short alleles are significantly more frequent in ALL patients in comparison to the control group, and that their presence may be associated with a higher risk of treatment failure, reflecting the role of HO-1 in chemoresistance. We also observed that the presence of short alleles may predispose to develop chemotherapy-induced neutropenia. In case of SNP, the 413-T variant co-segregated with short or long alleles, while 413-A almost selectively co-segregated with long alleles, hence it is not possible to determine if SNPs are actually of phenotypic significance. Our results suggest that HO-1 can be a potential target to overcome the treatment failure in ALL patients.     

电网省地县调数据一体化管理平台建设

在电网调度运行的实际生产中,需要综合多个业务系统中的数据,并从中挖掘出有价值的电力运行信息。当前,省地县调度业务多通过调度电话或者邮件联系,同时业务系统分布在不同安全分区,缺乏有效的管理措施。文章阐述了电网省地县调度数据一体化管理平台,其具备提供数据收集、存储、自定义报表、数据加工等功能,使省地县调的纵向数据传输能力得到显著改善。     

Molecular Mechanisms of Fetal Tendon Regeneration Versus Adult Fibrous Repair

Tendinopathies are painful, disabling conditions that afflict 25% of the adult human population. Filling an unmet need for realistic large-animal models, we here present an ovine model of tendon injury for the comparative study of adult scarring repair and fetal regeneration. Complete regeneration of the fetal tendon within 28 days is demonstrated, while adult tendon defects remained macroscopically and histologically evident five months post-injury. In addition to a comprehensive histological assessment, proteome analyses of secretomes were performed. Confirming histological data, a specific and pronounced inflammation accompanied by activation of neutrophils in adult tendon defects was observed, corroborated by the significant up-regulation of pro-inflammatory factors, neutrophil attracting chemokines, the release of potentially tissue-damaging antimicrobial and extracellular matrix-degrading enzymes, and a response to oxidative stress. In contrast, secreted proteins of injured fetal tendons included proteins initiating the resolution of inflammation or promoting functional extracellular matrix production. These results demonstrate the power and relevance of our novel ovine fetal tendon regeneration model, which thus promises to accelerate research in the field. First insights from the model already support our molecular understanding of successful fetal tendon healing processes and may guide improved therapeutic strategies.     

Multicomponent Bioluminescence Imaging with Naphthylamino Luciferins

Bioluminescent tools have been used for decades to image processes in complex tissues and preclinical models. However, few distinct probes are available to probe multicellular interactions. We and others are addressing this limitation by engineering new luciferases that can selectively process synthetic luciferin analogues. In this work, we explored naphthylamino luciferins as orthogonal bioluminescent probes. Three analogues were prepared using an optimized synthetic route. The luciferins were found to be robust emitters with native luciferase in vitro and in cellulo. We further screened the analogues against libraries of luciferase mutants to identify unique enzyme-substrate pairs. The new probes can be used in conjunction with existing bioluminescent tools for multi-component imaging.     

高密度脉冲电流对2024铝合金凝固组织的影响

研究了把高密度脉冲电流以外部瞬间能量和环境作功的形式注入到凝固过程中的高熔点2024铝合金熔体以细化其凝固组织，结果表明，高密度脉冲电流可以显著细化其凝固组织，讨论了高密度脉冲电流细化凝固组织的机理，指出了需要进一步解决的新问题。