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11.
Mateusz Sypniewski Zbigniew J. Krl Joanna Szyda Elbieta Kaja Magdalena Mroczek Tomasz Suchocki Adrian Lejman Maria Stpie Piotr Topolski Maciej Dbrowski Krzysztof Kotlarz Angelika Aplas Micha Wasiak Marzena Wojtaszewska Pawe Zawadzki Agnieszka Pawlak Robert Gil Paula Dobosz Joanna Stojak 《International journal of molecular sciences》2022,23(15)
Background: Severe outcomes of COVID-19 account for up to 15% of all cases. The study aims to check if any gene variants related to cardiovascular (CVD) and pulmonary diseases (PD) are correlated with a severe outcome of COVID-19 in a Polish cohort of COVID-19 patients. Methods: In this study, a subset of 747 samples from unrelated individuals collected across Poland in 2020 and 2021 was used and whole-genome sequencing was performed. Results: The GWAS analysis of SNPs and short indels located in genes related to CVD identified one variant significant in COVID-19 severe outcome in the HADHA gene, while for the PD gene panel, we found two significant variants in the DRC1 gene. In this study, both potentially protective and risk variants were identified, of which variants in the HADHA gene deserve the most attention. Conclusions: This is the first study reporting the association between the HADHA and DRC1 genetic variants and COVID-19 severe outcome based on the cohort WGS analysis. Although all the identified variants are localised in introns, they may be correlated and therefore inherited along with other risk variants, potentially causative to severe outcome of COVID-19 but not discovered yet. 相似文献
12.
13.
Barbara Sita Mihaela Bobi-Rasonja Goran Mrak Sara Trnski Magdalena Krbot Skori Darko Orekovi Vinka Knezovi
eljka Petelin Gade Zdravko Petanjek Goran imi Danijela Kolenc Nataa Jovanov Miloevi 《International journal of molecular sciences》2022,23(15)
The extracellular matrix (ECM) is an important regulator of excitability and synaptic plasticity, especially in its highly condensed form, the perineuronal nets (PNN). In patients with drug-resistant mesial temporal lobe epilepsy (MTLE), hippocampal sclerosis type 1 (HS1) is the most common histopathological finding. This study aimed to evaluate the ECM profile of HS1 in surgically treated drug-resistant patients with MTLE in correlation to clinical findings. Hippocampal sections were immunohistochemically stained for aggrecan, neurocan, versican, chondroitin-sulfate (CS56), fibronectin, Wisteria floribunda agglutinin (WFA), a nuclear neuronal marker (NeuN), parvalbumin (PV), and glial-fibrillary-acidic-protein (GFAP). In HS1, besides the reduced number of neurons and astrogliosis, we found a significantly changed expression pattern of versican, neurocan, aggrecan, WFA-specific glycosylation, and a reduced number of PNNs. Patients with a lower number of epileptic episodes had a less intense diffuse WFA staining in Cornu Ammonis (CA) fields. Our findings suggest that PNN reduction, changed ECM protein, and glycosylation expression pattern in HS1 might be involved in the pathogenesis and persistence of drug-resistant MTLE by contributing to the increase of CA pyramidal neurons’ excitability. This research corroborates the validity of ECM molecules and their modulators as a potential target for the development of new therapeutic approaches to drug-resistant epilepsy. 相似文献
14.
Aleksandra Obuchowska Kamila Gorczyca Arkadiusz Standyo Karolina Obuchowska aneta Kimber-Trojnar Magdalena Wierzchowska-Opoka Boena Leszczyska-Gorzelak 《International journal of molecular sciences》2022,23(15)
Probiotics are live microorganisms that induce health benefits in the host. Taking probiotics is generally safe and well tolerated by pregnant women and their children. Consumption of probiotics can result in both prophylactic and therapeutic effects. In healthy adult humans, the gut microbiome is stable at the level of the dominant taxa: Bacteroidetes, Firmicutes and Actinobacteria, and has a higher presence of Verrucomicrobia. During pregnancy, an increase in the number of Proteobacteria and Actinobacteria phyla and a decrease in the beneficial species Roseburia intestinalis and Faecalibacterium prausnitzii are observed. Pregnancy is a “window” to the mother’s future health. The aim of this paper is to review studies assessing the potentially beneficial effects of probiotics in preventing the development of diseases that appear during pregnancy, which are currently considered as risk factors for the development of metabolic syndrome, and consequently, reducing the risk of developing maternal metabolic syndrome in the future. The use of probiotics in gestational diabetes mellitus, preeclampsia and excessive gestational weight gain is reviewed. Probiotics are a relatively new intervention that can prevent the development of these disorders during pregnancy, and thus, would reduce the risk of metabolic syndrome resulting from these disorders in the mother’s future. 相似文献
15.
Anna Sowiska-Baranowska Magdalena Maciejewska Paulina Duda 《International journal of molecular sciences》2022,23(14)
The goal of this study was application of corn starch and ground walnut shells in various amounts by weight as biofillers of natural rubber (NR) biocomposites. Additionally, ionic liquid 1-butyl-3-methylimidazolium chloride (BmiCl) and (3-aminopropyl)-triethoxysilane (APTES) were used to increase the activity of biofillers and to improve the curing characteristics of NR composites. The effect of biofillers used and their modification with aminosilane or ionic liquid on the curing characteristics of NR composites and their functional properties, including crosslink density, mechanical properties in static and dynamic conditions, hardness, thermal stability and resistance to thermo-oxidative aging were investigated. Starch and ground walnut shells were classified as inactive fillers, which can be used alternatively to commercial inactive fillers, e.g., chalk. BmiCl and APTES were successfully used to support the vulcanization and to improve the dispersion of biofillers in NR elastomer matrix. Vulcanizates with starch, especially those containing APTES and BmiCl, exhibited improved tensile properties due to the higher crosslink density and homogenous dispersion of starch, which resulted from BmiCl addition. NR filled with ground walnut shells demonstrated improved resistance to thermo-oxidative aging. It resulted from lignin present in walnut shells, the components of which belong to polyphenols, that have an antioxidant activity. 相似文献
16.
Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model
Grzegorz K. Przybylski Dorota Korsak Katarzyna Iykowska Karina Nowicka Tomasz Zalewski Magorzata Tubacka Maria Mosor Danuta Januszkiewicz-Lewandowska Magdalena Frydrychowicz Maciej Boruczkowski Grzegorz Dworacki Jens van den Brandt Piotr Grabarczyk Christian A. Schmidt Chengwu Zeng Yangqiu Li 《International journal of molecular sciences》2022,23(9)
17.
Andres Castellanos‐Gomez Magdalena Wojtaszek Nikolaos Tombros Nicolás Agraït Bart J. van Wees Gabino Rubio‐Bollinger 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(17):2491-2497
By mechanical exfoliation, it is possible to deposit atomically thin mica flakes down to single‐monolayer thickness on SiO2/Si wafers. The optical contrast of these mica flakes on top of a SiO2/Si substrate depends on their thickness, the illumination wavelength, and the SiO2 substrate thickness, and can be quantitatively accounted for by a Fresnel‐law‐based model. The preparation of atomically thin insulating crystalline sheets will enable the fabrication of ultrathin, defect‐free insulating substrates, dielectric barriers, or planar electron‐tunneling junctions. Additionally, it is shown that few‐layer graphene flakes can be deposited on top of a previously transferred mica flake. Our transfer method relies on viscoelastic stamps, as used for soft lithography. A Raman spectroscopy study shows that such an all‐dry deposition technique yields cleaner and higher‐quality flakes than conventional wet‐transfer procedures based on lithographic resists. 相似文献
18.
E. William Barrera M. Cinta Pujol Concepción Cascales Joan J. Carvajal X. Mateos R. Solé J. Massons Magdalena Aguiló Francesc Díaz 《Optical Materials》2011,34(2):355-359
We synthesized crystalline Erbium Er3+ and Ytterbium Yb3+ codoped -Lu2O3 nanolayers on SiO2 microspheres using the modified Pechini method. Two different kinds of precursors, nitrates and chlorides, have been used leading to a layer-to-layer morphology and necklaces structures, respectively. In both cases, the size of nanocrystallites constituting the optical active layer is around 5 nm. We performed X-ray powder diffraction to confirm the cubic crystalline structure of the sesquioxides layer. High resolution transmission electron microscopy analyses corroborate the crystalline nature of the layer. The optical emission of Er3+ in the visible range has been recorded. 相似文献
19.
The circular dichroism (CD) spectra in visible range of the 3-nitroaniline (m-NA) single crystal, of its solution in chloroform, and in the KBr pellet were recorded. Neither the molecular (m or Cs) nor the crystal (mm2 or C2v) point groups belong to the chiral groups. The DFT calculation of CD spectrum of the m-NA isolated neutral molecule confirmed its chirality. The red shifted bands in the calculated CD spectrum of m-NA radical anion (charged polaron), as compared with the neutral molecule, resemble better the spectra of solids than that of the solution. It seems that these facts corroborate qualitatively the “hop and turn” model explaining the m-NA optical nonlinearity and electric conductivity proposed in Szostak et al. [M.M. Szostak, H. Chojnacki, E. Staryga, M. D?u?niewski, G. B?k, Chem. Phys. 365 (2009) 44-52]. 相似文献