Opportunities and Challenges in Biomedical Applications of Metal–Organic Frameworks

Journal of Inorganic and Organometallic Polymers and Materials - Unique chemical and physical properties of metal–organic framework (MOF) nanoparticles suggest them as promising candidates...     

Reactive synthesis with maximum realizability of linear temporal logic specifications

Acta Informatica - A challenging problem for autonomous systems is to synthesize a reactive controller that conforms to a set of given correctness properties. Linear temporal logic (LTL) provides a...     

Space syntax analysis of tourists’ movement patterns in the historical district of Kuala Lumpur,Malaysia

Although many researchers study the walkable environment and physical activities, very few studies demonstrate the important functions of walkable places on tourists’ walking experiences, particularly in Southeast Asian cities. This article evaluates pedestrian networks’ connectivity in Kuala Lumpur’s historic district to support pedestrian tourists’ movement patterns. The methods used in this study are gate observation and space syntax (integration value) analysis. The results indicate that pedestrian movement in the study areas is oriented more to land uses and elements of attractors than to connectivity of walkways. The findings suggest that pedestrian-oriented environments could contribute to the walkability of city centers through the integration of diverse place uses and street activities. The findings can be a useful reference for future urban studies and urban design of walkability to regenerate historical city centers that have lost their importance for tourists.     

A Hierarchical 3D Nanostructured Microfluidic Device for Sensitive Detection of Pathogenic Bacteria

Efficient capture and rapid detection of pathogenic bacteria from body fluids lead to early diagnostics of bacterial infections and significantly enhance the survival rate. We propose a universal nano/microfluidic device integrated with a 3D nanostructured detection platform for sensitive and quantifiable detection of pathogenic bacteria. Surface characterization of the nanostructured detection platform confirms a uniform distribution of hierarchical 3D nano‐/microisland (NMI) structures with spatial orientation and nanorough protrusions. The hierarchical 3D NMI is the unique characteristic of the integrated device, which enables enhanced capture and quantifiable detection of bacteria via both a probe‐free and immunoaffinity detection method. As a proof of principle, we demonstrate probe‐free capture of pathogenic Escherichia coli (E. coli) and immunocapture of methicillin‐resistant‐Staphylococcus aureus (MRSA). Our device demonstrates a linear range between 50 and 10⁴ CFU mL^?1, with average efficiency of 93% and 85% for probe‐free detection of E. coli and immunoaffinity detection of MRSA, respectively. It is successfully demonstrated that the spatial orientation of 3D NMIs contributes in quantifiable detection of fluorescently labeled bacteria, while the nanorough protrusions contribute in probe‐free capture of bacteria. The ease of fabrication, integration, and implementation can inspire future point‐of‐care devices based on nanomaterial interfaces for sensitive and high‐throughput optical detection.     

Adsorption of cerium and lanthanum from aqueous solutions by chitosan/polyvinyl alcohol/3-mercaptopropyltrimethoxysilane beads in batch and fixed-bed systems

Adsorption of La(III) and Ce(III) from aqueous solutions by novel chitosan modified with poly(vinyl alcohol) as a promoter of mechanical and chemical properties and 3-mercaptopropyltrimethoxysilane as a promoter of the functional group was investigated in batch and continuous modes. The FTIR analyses showed that mecapto groups have been successfully added to chitosan/poly(vinyl alcohol). The BET surface area, pore diameter, and pore volume of adsorbents were 1.68?m² g^?1, 2.516?nm, and 0.058?cm³ g^?1, respectively. The effects of the operating parameters such as pH, contact time, initial metal ion concentration, adsorbent dosage, and temperature were studied in batch mode operation. Optimum pH was found to be 5. According to the Langmuir model, the maximum adsorption capacities for La(III) and Ce(III) ions were 263.16 and 251.41?mg?g^?1, respectively. The thermodynamic study showed that the adsorption process of both metal ions was endothermic and spontaneous favored at the higher temperature. In the column study, the effects of the flow rate and initial concentration were investigated. The maximum adsorption capacities based on the Thomas model for La(III) and Ce(III) ions were 460.94 and 374.83?mg?g^?1 at a flow rate of 4?mL min^?1 and an initial metal concentration of 300?mg?L^?1, respectively.     

Large Deflection Compressional Analysis of Unsymmetric Delaminated Composite Plates with Consideration of Contact Phenomenon

In this study, an efficient method is developed to investigate the compressive large deflection behavior of unsymmetric composite laminates with multiple through-the-width delaminations. The analytical method is based on the first order shear deformation theory (FSDT) and its formulation is developed on the basis of the Rayleigh-Ritz approximation technique by the implementation of the simple and complete polynomial series. The method can handle both local deflection of the delaminated sublaminate and global deflection of the whole plate. Also, the contact among sublaminates is investigated. The three-dimensional finite element analysis is performed by using ANSYS5.4 general purpose commercial software, and the results are compared with those obtained by the analytical model.     

Macronutrients, vitamins and minerals intake and risk of esophageal squamous cell carcinoma: a case-control study in Iran

Background

Although Iran is a high-risk region for esophageal squamous cell carcinoma (ESCC), dietary factors that may contribute to this high incidence have not been thoroughly studied. The aim of this study was to evaluate the effect of macronutrients, vitamins and minerals on the risk of ESCC.

Methods

In this hospital-based case-control study, 47 cases with incident ESCC and 96 controls were interviewed and usual dietary intakes were collected using a validated food frequency questionnaire. Data were modeled through unconditional multiple logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), controlling for age, sex, gastrointestinal reflux, body mass index, smoking history (status, intensity and duration), physical activity, and education.

Results

ESCC cases consumed significantly more hot foods and beverages and fried and barbecued meals, compared to the controls (p < 0.05). After adjusting for potential confounders, the risk of ESCC increased significantly in the highest tertiles of saturated fat [OR:2.88,95%CI:1.15-3.08], cholesterol [OR:1.53, 95%CI: 1.41-4.13], discretionary calorie [OR:1.51, 95%CI: 1.06-3.84], sodium [OR:1.49,95%CI:1.12-2.89] and total fat intakes [OR:1.48, 95%CI:1.09-3.04]. In contrast, being in the highest tertile of carbohydrate, dietary fiber and (n-3) fatty acid intake reduced the ESCC risk by 78%, 71% and 68%, respectively. The most cancer-protective effect was observed for the combination of high folate and vitamin E intakes (OR: 0.02, 95%CI: 0.00-0.87; p < 0.001). Controls consumed 623.5 times higher selenium, 5.48 times as much β-carotene and 1.98 times as much α-tocopherol as the amount ESCC cases consumed.

Conclusion

This study suggests that high intake of nutrients primarily found in plant-based foods is associated with a reduced esophageal cancer risk. Some nutrients such as folate, vitamin E and selenium might play major roles in the etiology of ESCC and their status may eventually be used as an epidemiological marker for esophageal cancer in Iran, and perhaps other high-risk regions.     

Experimental and CFD investigation of power consumption in a dual Rushton turbine stirred tank

Power consumption of a mixing system is a key variable in chemical and bioprocess engineering, the determination of which is of interest of many processes. Besides, prediction of the flooding-loading transition in an aerated stirred tank is crucial for the correct design of aerated stirred tank reactors. In this research, laboratory investigation has been carried out on local and total power consumption of a single phase as well as gas-liquid phase systems in a fully baffled stirred tank equipped with dual six-blade Rushton turbines; moreover, the flow regime behavior of a gas-liquid system was investigated. Results have been compared with data obtained from CFD simulation of experimental setup and the data available in the literature. Reasonable agreement between the experimental and simulation results indicates the validity of the CFD model. Using predicted data some empirical correlations have been derived which present new relations in estimation of power consumption and flow regime transitions in stirred tanks with dual Rushton impellers.     

Survivin as a Preferential Target for Cancer Therapy

Cancer is typically a consequence of imbalance between cell death and proliferation in a way favorable to cell proliferation and survival. Most conventional cancer therapies are based on targeting rapidly growing cancerous cells to block growth or enhance cell death, thereby, restoring the balance between these processes. In many instances, malignancies that develop resistance to current treatment modalities, such as chemotherapy, immunotherapy, and radiotherapy often present the greatest challenge in subsequent management of the patient. Studies have shown that under normal circumstances, cells utilize different death mechanisms, such as apoptosis (programmed cell death), autophagy, mitotic catastrophe, and necrosis to maintain homeostasis and physiological integrity of the organism, but these processes often appear to be altered in cancer. Thus, in recent years developing various strategies for administration of cytotoxic chemotherapeutics in combination with apoptosis-sensitizing reagents is receiving more emphasis. Here, we review the properties of the anti-apoptotic protein, survivin, a member of the inhibitor of apoptosis protein (IAP) family and the clinical feasibility and anti-cancer potential of drugs targeting this protein. We also discuss some key points and concerns that should be taken into consideration while developing drugs that target apoptotic proteins, such as survivin.