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71.
This paper presents the silicon based on-chip antenna using a LC resonator. The proposed antenna consists of a stacked capacitor and a spiral inductor on silicon substrate. The spiral inductor structure without underpass was proposed for improvement the performance of the silicon based-antenna. The resonant frequency of the fabricated antenna was measured as 465 MHz. Its return loss was 23.4 dB at resonant frequency. The antenna has a gain of ?35.75 dBi due to small size and silicon substrate. However, the fabricated antenna has good performance in the near-field. 相似文献
72.
Takako Otabe Tomochika Kaneda Makoto Yoshikai Tatushi Tokuyasu 《Artificial Life and Robotics》2016,21(1):79-84
Resilience is a concept which presents the strength of mind necessary to adopt the difficulties and to recover from negative psychological state. The assessment for resilience has been assessed by using interview and questionnaire which depend on subjectivity of participants. Though the objective assessment for resilience is expected to advance the biofeedback treatment, neither effective method nor instrument have been developed. Then this study focuses on the pliability as one of aspects of resilience and experimentally verifies whether it becomes a novel index for resilience or not. 相似文献
73.
Kenji Imai Koji Takai Tatsunori Hanai Makoto Shiraki Yusuke Suzuki Hideki Hayashi Takafumi Naiki Youichi Nishigaki Eiichi Tomita Masahito Shimizu Hisataka Moriwaki 《International journal of molecular sciences》2014,15(7):11294-11306
Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves in hepatocellular carcinoma (HCC) patients and on the recurrence and prognosis of HCC. This study included 44 patients with any stage of HCC who underwent curative treatment at Gifu Municipal Hospital (Gifu, Japan) between 2006 and 2007. Recurrence-free survival and overall survival were estimated using the Kaplan-Meier method. Serum albumin levels (Pearson’s correlation coefficient; r = 0.3110, p = 0.0399), platelet counts (r = 0.4159, p = 0.0050), and prothrombin times (r = 0.3775, p = 0.0115) were significantly correlated with serum chemerin levels in patients with HCC, and they were inversely correlated with Child-Pugh scores (r = −0.3732, p = 0.0126), serum alanine aminotransferase levels (r = −0.3864, p = 0.0105), and total bilirubin levels (r = −0.4023, p = 0.0068). Among these variables, a multiple comparison test identified that platelet counts and total bilirubin levels were associated with serum chemerin levels (p < 0.0083). No significant correlation was found between serum chemerin levels and recurrence-free survival (p = 0.3691) or overall survival (p = 0.7916). In HCC patients, serum chemerin concentrations were correlated with liver functional reserves and platelet counts, but not with recurrence or prognosis. 相似文献
74.
Makoto Morinaga Naoki Sako Mari Isobe Sachiko Lee-Hotta Hideshi Sugiura Satoshi Kametaka 《International journal of molecular sciences》2021,22(6)
Cachexia is a multifactorial syndrome characterized by muscle loss that cannot be reversed by conventional nutritional support. To uncover the molecular basis underlying the onset of cancer cachectic muscle wasting and establish an effective intervention against muscle loss, we used a cancer cachectic mouse model and examined the effects of aerobic exercise. Aerobic exercise successfully suppressed muscle atrophy and activated adiponectin signaling. Next, a cellular model for cancer cachectic muscle atrophy using C2C12 myotubes was prepared by treating myotubes with a conditioned medium from a culture of colon-26 cancer cells. Treatment of the atrophic myotubes with recombinant adiponectin was protective against the thinning of cells through the increased production of p-mTOR and suppression of LC3-II. Altogether, these findings suggest that the activation of adiponectin signaling could be part of the molecular mechanisms by which aerobic exercise ameliorates cancer cachexia-induced muscle wasting. 相似文献
75.
Haruto Kumura Megumi Satoh Taiki Machiya Makoto Hosono Toru Hayakawa Jun‐ichi Wakamatsu 《International Journal of Dairy Technology》2019,72(3):403-408
The lipolytic and proteolytic activity of Penicillium camemberti PC TT033 and Penicillium roqueforti PR G3, cultured on the whey solids or simulated cheese media, were compared under several pH reaction conditions. Lipolytic activity was higher when both strains had been cultured on the whey medium than on the simulated cheese medium, whereas proteolytic activity was less influenced by the culture medium. The relationship between the reaction pH and these enzyme activities was dependent on the culture medium, which suggested that the expression level and balance of isozyme rely on the culture substrate. 相似文献
76.
Ryusei Terui Yuta Yanase Dr. Hidetomo Yokoo Prof. Yoshitomo Suhara Prof. Makoto Makishima Dr. Yosuke Demizu Dr. Takashi Misawa 《ChemMedChem》2021,16(3):458-462
TGR5, a G-protein-coupled receptor (GPCR), plays an important role in several physiological functions. TGR5 activation through bile acids induces an increase in energy expenditure. Therefore, synthetic TGR5 ligands could be useful for the treatment of obesity or dyslipidemia. In this study, we designed and synthesized a set of TGR5 ligands with a 5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene (TMN) skeleton, and evaluated their TGR5 agonistic activity. We also investigated the selectivity of the synthesized compounds for TGR5 relative to the farnesoid X receptor (FXR) and retinoic acid receptor (RAR). Our results show that compound 4 b [N-(2-chlorophenyl)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenecarboxamide] exhibited potent TGR5 agonist activity with an IC50 value of 8.4 nM without significant cytotoxicity. In addition, compound 4 b showed only slight agonistic activity toward FXR and RAR at 1 μM treatment. These data indicate that compound 4 b is a selective TGR5 agonist, and could be a promising therapeutic agent for dyslipidemia. 相似文献
77.
Jianming Zhu Dr. Jing Wang Kai Cheng Hui Chen Dr. Ran An Dr. Yaping Zhang Prof. Makoto Komiyama Prof. Xingguo Liang 《Chembiochem : a European journal of chemical biology》2020,21(6):785-788
High-resolution melting (HRM) analysis has been improved and applied for the first time to quantitative analysis of enzymatic reactions. By using the relative ratios of peak intensities of substrates and products, the quantitativity of conventional HRM analysis has been improved to allow detailed kinetic analysis. As an example, the ligation of sticky ends through the action of T4 DNA ligase has been kinetically analyzed, with comprehensive data on substrate specificity and other properties having been obtained. For the first time, the kinetic parameters (kobs and apparent Km) of sticky-end ligation were obtained for both fully matched and mismatched sticky ends. The effect of ATP concentration on sticky-end ligation was also investigated. The improved HRM method should also be applicable to versatile DNA-transforming enzymes, because the only requirement is that the products have Tm values different enough from the substrates. 相似文献
78.
79.
In energy-aware information systems, it is critical to discuss how to select a server for each request from clients in order to not only achieve performance objectives but also reduce the total power consumption of a system. In order to design and evaluate the server selection algorithm, it is critical to define the power consumption model of a server to perform processes. In our previous studies, the transmission power consumption (TPC) model of a server is proposed to perform transmission processes. In the TPC model, the electric power consumption of cooling devices is assumed to be constant. Cooling devices like fans consume the electric power in a server. Thus, the total power consumption of a server depends on not only computation and communication devices but also cooling devices. In this paper, we propose the extended TPC (ETPC) model to take into account the power consumption of cooling devices. We validate the TPC and ETPC models by measuring the power consumption and transmission time of a server. 相似文献
80.
Kazuhiro Kanda Noriko Yamada Kumiko Yokota Masahito Tagawa Masahito Niibe Makoto Okada Yuichi Haruyama Shinji Matsui 《Diamond and Related Materials》2011,20(5-6):703-706
Surface modification of diamond-like carbon (DLC) film was performed using a hyperthermal atomic fluorine beam on the purpose of production of hydrophobic surface by maintaining the high hardness of DLC film. By the irradiation of atomic fluorine beam of a 1.0 × 1020 atoms/cm2, the contact angle of a water drop against the DLC surface increased from 73° to 111°. The formation of CF3, CF2 and CF bonding on the modified DLC surface was confirmed from the measurements of X-ray photoelectron spectra and near-edge X-ray absorption fine structure spectra. Irradiation of hyperthermal atomic fluorine beam was concluded to produce insulator fluorine-terminated DLC film, which has high F content on the surface, by the taking of the use of neutral atomic beam as a fluorine source. 相似文献