Intelligent assistance for software development and maintenance

An environment is described, called Professor Marvel, that provides early error checking and answers questions about the program under development. The environment has a certain understanding of the systems being developed and how to use tools to produce software. It aids individual programmers and helps coordinate programming teams. The key components of Marvel are a database that stores data represented as objects, as in object-oriented languages, and a model of the development process that imposes a structure on programming activities. Marvel's support of insight and of opportunistic processing is discussed at length, as is the handling of side effects. A sample session is described     

An extension of the tearing instability theory to multiple loading parameters

The stability of a cracked, nonlinear component connected to an elastic structure and subjected to an arbitrary number of controlled loads or displacements, is discussed. First this is done with a general instability criterion expressed in terms of loads and displacements of the cracked part. Then general expressions for the tearing modulus are given for different loading situations. Finally the given equations are applied to SEN specimens under bending and tension.

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Résumé On discute de la stabilité d'un composant fissuré et non linéaire assemblé à une structure élastique et soumis à un monbre quelconque de charges ou de déplacements, appliqués dans des conditions connues. Ceci est réalisé en faisant appel, en premier lieu, à un critère général d'instabilité exprimé en termes the sollicitation et de déplacement de la portion fissurée. Ensuite, on fournit des expressions générales pour le module d'arrachement, correspondant à diverses situations de mise en charge. Enfin, les équations obtenues sont appliquées à des éprouvettes à entaille latérale simple soumises à flexion et traction.

     

DMT／PTA工艺的技术改进

改进的DMT/PTA工艺技术是由苏尔寿化工有限公司和H&G Hegmanns公司联合开发的。该技术对Witten-Katzschmann工艺进行了大量改进,并结合了苏尔寿公司的环境友好熔融结晶技术。改进的工艺包括:氧化反应部分(有效回收了副产品和能量);粗酯和副产品蒸馏;采用熔融结晶技术精制DMT。     

MANOVA method for analyzing repeated measures designs: An extensive primer.

Contends that tests in repeated-measures designs based on MANOVA are free of sphericity assumptions, and with modern computing software, MANOVA is straightforward to use, even for complex designs and nontraditional hypotheses. A general strategy for implementing MANOVA within statistical computing packages is presented. Regular (preplanned) tests and simultaneous (post hoc) tests are illustrated for a variety of designs and hypotheses. Optimal contrasts for unbalanced repeated measures designs are appended. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1

Ubiquitin-mediated proteolysis controls the abundance of many cell cycle regulatory proteins. Recent work in Saccharomyces cerevisiae suggests that a complex consisting of Cdc53, Skp1, and a third component known as an F-box protein (termed SCF) in combination with Cdc34 specifically targets regulatory proteins for degradation, and that substrate specificity is likely to be mediated by the F-box subunit. A screen for genetic interactions with a cdc34 mutation yielded MET30, which encodes an F-box protein. MET30 is an essential gene required for cell cycle progression and met30 mutations interact genetically with mutations in SCF components. Furthermore, physical interactions between Met30, Cdc53, Cdc34, and Skp1 in vivo provide evidence for an SCFMet30 complex. We demonstrate the involvement of Met30 in the degradation of the Cdk-inhibitory kinase Swe1. Swe1 is stabilized in met30 mutants and GST-Met30 pull-down experiments reveal that Met30 specifically binds Swe1 in vivo. Furthermore, extracts prepared from cdc34 or met30 mutants are defective in polyubiquitination of Swe1. Taken together, these data suggest that SCF-mediated proteolysis may contribute to the regulation of entry into mitosis. Our data, in combination with previously published results, also provide evidence for distinct SCF complexes in vivo and support the idea that their F-box subunits mediate SCF substrate specificity.     

Darstellung komplexer Betriebsschlacken des LD-Verfahrens im Quasidreistoffsystem

Aus der Darstellung der Schlackenzusammensetzungen im Quasidreistoffsystem ist die Lage der Schlacken zur Kalksättigungslinie deutlich zu erkennen. Die Sublanzenschlacken lassen den Schlackenweg während der letzten Blasminuten erkennen, durch Bodenspülung und Nachspülen wird eine geringe Annäherung an die Kalksättigungslinie erreicht. Aus der Lage der Schlacken im Quasidreistoffsystem läßt sich der Einfluß der Temperatur auf den Verlauf der Kalksättigung entlang unterschiedlicher T-X-Schnitte bestimmen.     

Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders

As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing the well-being and quality of life of sufferers and their families. In recent decades, due to reduced work-related levels of physical activity, and key research insights, prescribing adequate exercise has become an innovative strategy to prevent or delay the onset of these pathologies and has been demonstrated to have therapeutic benefits when used as a sole or combination treatment. Recent evidence suggests that the beneficial effects of exercise on the brain are related to several underlying mechanisms related to muscle–brain, liver–brain and gut–brain crosstalk. Therefore, this review aims to summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and to highlight the established and potential underlying mechanisms involved in exercise–brain communication and their benefits for physiology and brain function.     

Processing of High-Density Submicrometer Al2O3 for New Applications

Sintered corundum components with submicrometer grain sizes exhibit properties which enable numerous new applications. Wet powder processing is developed to associate minimum grain sizes at highest densities with the lowest population of macrodefects. A closest ratio of powder particle size and sintered grain size is important for obtaining most fine-grained microstructures. This target was approached best by using powders with particle sizes in the range of 100–200 nm rather than with smaller nanoparticles.     

Flüssig/Flüssig-Extraktion: Einsatzgebiete und Lösungsmittel-Auswahl

Liquid/liquid extraction: Applications and choice of solvent . The significance of liquid/liquid extraction has been steadily increasing in recent years as more and more stringent demands are made on the purity, availability, and environmental safety of chemical products. The use and success of this separation process are critically dependent upon the choice of the right extraction agent. Whereas solvent choice was previously mainly empirical, it is now possible to establish the suitability of a given solvent with the aid of molecular-thermodynamic data. This is demonstrated for the extraction of aromatic compounds. The article closes with an account of the formation and stability of emulsions.