全文获取类型
收费全文 | 2391篇 |
免费 | 68篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 21篇 |
综合类 | 5篇 |
化学工业 | 963篇 |
金属工艺 | 41篇 |
机械仪表 | 41篇 |
建筑科学 | 197篇 |
矿业工程 | 6篇 |
能源动力 | 65篇 |
轻工业 | 190篇 |
水利工程 | 13篇 |
石油天然气 | 2篇 |
武器工业 | 4篇 |
无线电 | 124篇 |
一般工业技术 | 313篇 |
冶金工业 | 143篇 |
原子能技术 | 32篇 |
自动化技术 | 301篇 |
出版年
2022年 | 22篇 |
2021年 | 52篇 |
2020年 | 29篇 |
2019年 | 27篇 |
2018年 | 37篇 |
2017年 | 25篇 |
2016年 | 64篇 |
2015年 | 56篇 |
2014年 | 55篇 |
2013年 | 103篇 |
2012年 | 91篇 |
2011年 | 120篇 |
2010年 | 99篇 |
2009年 | 102篇 |
2008年 | 96篇 |
2007年 | 84篇 |
2006年 | 90篇 |
2005年 | 80篇 |
2004年 | 64篇 |
2003年 | 44篇 |
2002年 | 51篇 |
2001年 | 45篇 |
2000年 | 52篇 |
1999年 | 63篇 |
1998年 | 61篇 |
1997年 | 58篇 |
1996年 | 53篇 |
1995年 | 56篇 |
1994年 | 45篇 |
1993年 | 29篇 |
1992年 | 41篇 |
1991年 | 40篇 |
1990年 | 31篇 |
1989年 | 40篇 |
1988年 | 26篇 |
1987年 | 32篇 |
1986年 | 29篇 |
1985年 | 23篇 |
1984年 | 31篇 |
1983年 | 27篇 |
1982年 | 18篇 |
1981年 | 29篇 |
1980年 | 23篇 |
1979年 | 19篇 |
1978年 | 21篇 |
1977年 | 22篇 |
1976年 | 18篇 |
1975年 | 18篇 |
1974年 | 21篇 |
1973年 | 19篇 |
排序方式: 共有2461条查询结果,搜索用时 15 毫秒
91.
4‐Biphenylalanine‐ and 3‐Phenyltyrosine‐Derived Hydroxamic Acids as Inhibitors of the JumonjiC‐Domain‐Containing Histone Demethylase KDM4A 下载免费PDF全文
Dr. Ludovica Morera Dr. Martin Roatsch Michael C. D. Fürst Dr. Inga Hoffmann Dr. Johanna Senger Mirjam Hau Dr. Henriette Franz Prof. Dr. Roland Schüle Prof. Dr. Markus R. Heinrich Prof. Dr. Manfred Jung 《ChemMedChem》2016,11(18):2063-2083
Overexpression of the histone lysine demethylase KDM4A, which regulates H3K9 and H3K36 methylation states, has been related to the pathology of several human cancers. We found that a previously reported hydroxamate‐based histone deacetylase (HDAC) inhibitor (SW55) was also able to weakly inhibit this demethylase with an IC50 value of 25.4 μm . Herein we report the synthesis and biochemical evaluations, with two orthogonal in vitro assays, of a series of derivatives of this lead structure. With extensive chemical modifications on the lead structure, also by exploiting the versatility of the radical arylation with aryldiazonium salts, we were able to increase the potency of the derivatives against KDM4A to the low‐micromolar range and, more importantly, to obtain demethylase selectivity with respect to HDACs. Cell‐permeable derivatives clearly showed a demethylase‐inhibition‐dependent antiproliferative effect against HL‐60 human promyelocytic leukemia cells. 相似文献
92.
Identification and Structure–Activity Relationship Studies of Small‐Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1 下载免费PDF全文
Dr. Dina Robaa Dr. Tobias Wagner Chiara Luise Dr. Luca Carlino Joel McMillan Dr. Ralf Flaig Prof. Dr. Roland Schüle Prof. Dr. Manfred Jung Prof. Dr. Wolfgang Sippl 《ChemMedChem》2016,11(20):2327-2338
The methyllysine reader protein Spindlin1 has been implicated in the tumorigenesis of several types of cancer and may be an attractive novel therapeutic target. Small‐molecule inhibitors of Spindlin1 should be valuable as chemical probes as well as potential new therapeutics. We applied an iterative virtual screening campaign, encompassing structure‐ and ligand‐based approaches, to identify potential Spindlin1 inhibitors from databases of commercially available compounds. Our in silico studies coupled with in vitro testing were successful in identifying novel Spindlin1 inhibitors. Several 4‐aminoquinazoline and quinazolinethione derivatives were among the active hit compounds, which indicated that these scaffolds represent promising lead structures for the development of Spindlin1 inhibitors. Subsequent lead optimization studies were hence carried out, and numerous derivatives of both lead scaffolds were synthesized. This resulted in the discovery of novel inhibitors of Spindlin1 and helped explore the structure–activity relationships of these inhibitor series. 相似文献
93.
Rubber materials filled with reinforcing fillers display nonlinear rheological behavior at small strain amplitudes below γ0 < 0.1. Nevertheless, rheological data are analyzed mostly in terms of linear parameters, such as shear moduli (G′, G″), which loose their physical meaning in the nonlinear regime. In this work styrene butadiene rubber filled with carbon black (CB) under large amplitude oscillatory shear (LAOS) is analyzed in terms of the nonlinear parameter I3/1. Three different CB grades are used and the filler load is varied between 0 and 70 phr. It is found that I3/1(φ) is most sensitive to changes of the total accessible filler surface area at low strain amplitudes (γ0 = 0.32). The addition of up to 70 phr CB leads to an increase of I3/1(φ) by a factor of more than ten. The influence of the measurement temperature on I3/1 is pronounced for CB levels above the percolation threshold.
94.
Zaoli Zhang Wilfried SigleChristoph T. Koch Manfred Rühle 《Journal of the European Ceramic Society》2011,31(9):1835-1840
We report about the dynamic behavior of a nanometer-scale amorphous intergranular film (IGF) in a Si3N4 ceramic by an in situ heating experiment in a high-resolution transmission electron microscopy (HRTEM). During the experiment the IGF gradually vanishes at 820 °C accompanied by the formation of crystal planes within the IGF. The IGF reappears after cooling back to room temperature. The results cannot be explained within the framework of a force balance model. We argue that the dynamic behavior of the IGF in our experiment originates from the open system observed. 相似文献
95.
Manfred Schrewe Anders O. Magnusson Christian Willrodt Bruno Bühler Andreas Schmid 《Advanced Synthesis \u0026amp; Catalysis》2011,353(18):3485-3495
The alkane monooxygenase AlkBGT from Pseudomonas putida GPo1 constitutes a versatile enzyme system for the ω‐oxyfunctionalization of medium chain‐length alkanes. In this study, recombinant Escherichia coli W3110 expressing alkBGT was investigated as whole‐cell catalyst for the regioselective biooxidation of fatty acid methyl esters to terminal alcohols. The ω‐functionalized products are of general economic interest, serving as building blocks for polymer synthesis. The whole‐cell catalysts proved to functionalize fatty acid methyl esters with a medium length alkyl chain specifically at the ω‐position. The highest specific hydroxylation activity of 104 U gCDW−1 was obtained with nonanoic acid methyl ester as substrate using resting cells of E. coli W3110 (pBT10). In an optimized set‐up, maximal 9‐hydroxynonanoic acid methyl ester yields of 95% were achieved. For this specific substrate, apparent whole‐cell kinetic parameters were determined with a Vmax of 204±9 U gCDW−1, a substrate uptake constant (KS) of 142±17 μM, and a specificity constant Vmax/KS of 1.4 U gCDW−1 μM −1 for the formation of the terminal alcohol. The same E. coli strain carrying additional alk genes showed a different substrate selectivity. A comparison of biocatalysis with whole cells and enriched enzyme preparations showed that both substrate availability and enzyme specificity control the efficiency of the whole‐cell bioconversion of the longer and more hydrophobic substrate dodecanoic acid methyl ester. The efficient coupling of redox cofactor oxidation and product formation, as determined in vitro, combined with the high in vivo activities make E. coli W3110 (pBT10) a promising biocatalyst for the preparative synthesis of terminally functionalized fatty acid methyl esters. 相似文献
96.
97.
M. Masudul Hassan Marco Mueller Diana J. Tartakowska Manfred H. Wagner 《应用聚合物科学杂志》2011,120(3):1843-1849
Rice straw (Rs)/polypropylene (PP) composites were prepared in the different ratio of 5 : 95, 10 : 90, 15 : 85, 20 : 80, 25 : 75, and 30 : 70 (Rs wt % : PP wt %) by an injection molding process. This work investigated the tensile strength (TS), bending strength (BS), and impact strength (IS) of the composites. From the results, it is observed that Rs20 : PP80 mixture composite showed better performance with mechanical properties (TS = 26.2 MPa, BS = 58 N/mm2, and IS = 1.7 KJ/mm2) among the composites prepared. Two hybrid composites were also fabricated using 20% Rs, 10% seaweed with 70% PP and 20% Rs, 30% seaweed with 70% PP. In between the two hybrid composites, superior mechanical behavior showed by the hybrid composite in ratio of Rs20 : Sw10 : PP70 with enhanced results such as TS = 28 MPa, BS = 68 N/mm2, and IS = 2.5 KJ/mm2. Water uptake, simulating weathering, and soil degradation test of different composites were also performed. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 相似文献
98.
99.
The synthesis of new lanthanide allyl complexes of enhanced stability and solubility in saturated hydrocarbons based on silyl-substituted allyl ligands is reported. Thus the potassium salt K(CH2CHCHSiMe3) ( 1 ) reacts with YCl3 in tetrahydrofuran to give the tris-allyl complex Y(CH2CHCHSiMe3)3 ( 2 ), while K(CH2CHCHSiMe2tBu) ( 3 ) affords Y(CH2CHCHSiMe2tBu)3(THF)1.5 ( 4 ). Slow re-crystallization of 4 from light petroleum in the presence of tert-butylcyanide led to multiple insertion to give the sec-amido complex Y{NHC(tBu)(CH)3SiMe2tBu}2{η2-NHC(tBu)CH=CHCH2SiMe2tBu)CH(CHCHSiMe2tBu)CtBuNH}(THF)·(CH3CH(Me)(CH2)2CH3) ( 5 ), which was crystallographically characterized. The reaction of ScCl3(THF)3 with two equivalents of Li{1,3-C3H3(SiMe3)2} in tetrahydrofuran gives the bis-allyl complex {1,3-C3H3(SiMe3)2}2Sc(μ-Cl)2Li(THF)2 ( 6 ), while the analogous reaction of K{1,3-C3H3(SiMe3)2} ( 7 ) with either LaCl3 or YCl3 in tetrahydrofuran affords the bis-allyl complexes MCl{1,3-C3H3(SiMe3)2}2(THF)x (8, M = La, x = 1; 9, M = Y, x = 0). An attempt to prepare the similar neodymium complex gave the mono-allyl complex NdI2{1,3-C3H3(SiMe3)2}(THF)1.25 ( 10 ). The reactions of 8 and 9 with triisobutyl aluminum in benzene-d6 show allyl exchange between lanthanide and aluminum. Complexes 8 , 9 , and 10 have been tested with a variety of activator systems as catalysts for the polymerization of 1,3-butadiene. 相似文献
100.
Manfred Held 《Propellants, Explosives, Pyrotechnics》2002,27(4):244-246
The momentum equation used by the author to describe the transferred momentum in the near field of detonating high explosive charges can be very well applied to the test results of steel disks at very near distances to detonating high explosive cylinders of the publication of Weaver and Walters(1). 相似文献