A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen

Low level intake of drugs from the ingestion of contaminated feed may lead to residue problems in food animals. Sulfadimidine (SDD) was used as a model to determine the residue risk at various doses in laying hens. The drug was administered as a single intravenous injection (100 mg kg^-1 body weight, BW), as a single oral dose (100, 30, 10, 3, 1 mg kg^-1 BW) and via medicated feed for 7 consecutive days (30, 10, 3 mg kg^-1 BW). Drug levels were determined with HPLC-UV for plasma, yolk and albumen. Pharmacokinetic values, which were calculated using a first-order one-compartment model, residue levels and transfer rates into the eggs were found to be dose-dependent. Even low doses of 3 and 1 mg kg^-1 BW resulted in measurable residues in yolk and albumen 1 day after a single oral administration. After ingestion of medicated feed at 3 mg kg^-1 BW, mean drug levels at 0.14 ± 0.01 µg g^-1 were found in albumen and at 0.09 ± 0.01 µg ml^-1 in plasma. Generally, the residue levels in albumen and plasma were higher than in yolk. These findings demonstrate a residue risk for the consumer even after low level intake of drugs.     

Discrimination of facial appearance stimuli in body dysmorphic disorder.

Cognitive-behavioral models of body dysmorphic disorder (BDD) propose that information-processing biases--in particular, selective attention to a defect in one's appearance as well as improved aesthetical perception--might contribute to the development or maintenance of the disorder. In the present study, the authors tested the hypothesis that patients with BDD discriminate facial appearance stimuli more accurately than controls. Sixty female patients from a dermatological clinic participated in the study: 21 patients with BDD, 19 patients with disfiguring dermatological conditions, and 20 patients with nondisfiguring dermatological disorders. Participants rated dissimilarities between pictures of neutral faces that had been manipulated with regard to aesthetic characteristics. Manipulation ratings of participants with BDD were significantly more accurate than those of both control groups. Implications of these results for cognitive theories of BDD are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Guest Editorial: Special Issue on Computing Frontiers

Journal of Signal Processing Systems -     

Managing time-awareness in modularized processes

Software and Systems Modeling - Managing temporal process constraints in a suitable way is crucial for long-running business processes in many application domains. However, proper support of...     

Calculations on Mode Eigenvalues in a Corrugated Waveguide with Varying Diameter and Corrugation Depth

Journal of Infrared, Millimeter, and Terahertz Waves - The present paper addresses numerical calculations on the eigenvalues of hybrid modes in corrugated circular waveguides with varying diameter...     

Creating round focused micro-jets from rectangular nozzles

Journal of Mechanical Science and Technology - A focused jet is an axisymmetric jet of liquid surrounded by an outer coaxial gas jet. The gas jet is typically used to compress the liquid jet in the...