The preparation and characteristics of surface treated barium sulfate extender pigment

This article deals with the treatment of barium sulfate extender pigment with iron oxide and its phenomenological adsorption mechanism in the presence of H⁺ and OH^? ions in solution. The pH range taken in the present study is 5–6. By depositing a ferric oxide layer on barium sulfate particles a novel pigment with better optical and functional performance is obtained. This pigment in various coating systems improves physicochemical performance and acts as an active barrier. The treated pigments can be suitably used in different architectural and industrial coatings. The experimental techniques of surface treatment are discussed, along with the instrumental analysis by SEM, EDAX, XRD, etc.     

The Importance of Small Extracellular Vesicles in the Cerebral Metastatic Process

Brain metastases represent more than 50% of all cerebral tumors encountered in clinical practice. Recently, there has been increased interest in the study of extracellular vesicles, and the knowledge about exosomes is constantly expanding. Exosomes are drivers for organotropic metastatic spread, playing important roles in the brain metastatic process by increasing the permeability of the blood–brain barrier and preparing the premetastatic niche. The promising results of the latest experimental studies raise the possibility of one day using exosomes for liquid biopsies or as drug carriers, contributing to early diagnosis and improving the efficacy of chemotherapy in patients with brain metastases. In this review, we attempted to summarize the latest knowledge about the role of exosomes in the brain metastatic process and future research directions for the use of exosomes in patients suffering from brain metastatic disease.     

Molecular Docking Studies and Biological Evaluation of Berberine–Benzothiazole Derivatives as an Anti-Influenza Agent via Blocking of Neuraminidase

In this study, we have introduced newly synthesized substituted benzothiazole based berberine derivatives that have been analyzed for their in vitro and in silico biological properties. The activity towards various kinds of influenza virus strains by employing the cytopathic effect (CPE) and sulforhodamine B (SRB) assay. Several berberine–benzothiazole derivatives (BBDs), such as BBD1, BBD3, BBD4, BBD5, BBD7, and BBD11, demonstrated interesting anti-influenza virus activity on influenza A viruses (A/PR/8/34, A/Vic/3/75) and influenza B viral (B/Lee/40, and B/Maryland/1/59) strain, respectively. Furthermore, by testing neuraminidase activity (NA) with the neuraminidase assay kit, it was identified that BBD7 has potent neuraminidase activity. The molecular docking analysis further suggests that the BBD1–BBD14 compounds’ antiviral activity may be because of interaction with residues of NA, and the same as in oseltamivir.     

Emergence of Gold‐Mesoporous Silica Hybrid Nanotheranostics: Dox‐Encoded,Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication

Strategically fabricated theranostic nanocarrier delivery system is an unmet need in personalized medicine. Herein, this study reports a versatile folate receptor (FR) targeted nanoenvelope delivery system (TNEDS) fabricated with gold core silica shell followed by chitosan–folic acid conjugate surface functionalization by for precise loading of doxorubicin (Dox), resembled as Au@SiO₂‐Dox‐CS‐FA. TNEDS possesses up to 90% Dox loading efficiency and internalized through endocytosis pathway leading to pH and redox‐sensitive release kinetics. The superior FR‐targeted cytotoxicity is evaluated by the nanocarrier in comparison with US Food and Drug Administration (FDA)‐approved liposomal Dox conjugate, Lipodox. Moreover, TNEDS exhibits theranostic features through caspase‐mediated apoptosis and envisages high surface plasmon resonance enabling the nanoconstruct as a promising surface enhanced Raman scattering (SERS) nanotag. Minuscule changes in the biochemical components inside cells exerted by the TNEDS along with the Dox release are evaluated explicitly in a time‐dependent fashion using bimodal SERS/fluorescence nanoprobe. Finally, TNEDS displays superior antitumor response in FR‐positive ascites as well as solid tumor syngraft mouse models. Therefore, this futuristic TNEDS is expected to be a potential alternative as a clinically relevant theranostic nanomedicine to effectively combat neoplasia.     

Size-dependent cohesive energy of fcc nanomaterials

ABSTRACT

A theoretical model for the study of size dependent cohesive energy of face-centered cubic (fcc) nanomaterials has been developed by considering the cluster order and particle size of these materials. Using the newly developed theoretical model, cohesive energy of Au, Ag and Al nanomaterials have been calculated and compared with other theoretical models and existing experimental data. The comparison of theoretical findings of the present work indicates that present developed theoretical model is in good agreement with available experimental results which show the validity of our work.     

Optimal placement of piezoelectric patches over a smart structure

Control of structural vibrations has significant applications in manufacturing, infrastructure engineering, aerospace engineering and various consumer products. In last two decades, considerable attention has been focused to suppress structural vibrations using active vibration control technique. Various researchers have proposed various optimization criteria for optimal placement of piezoelectric patches over a smart structure to suppress vibrations using various optimization techniques. This paper presents a review of various optimization criteria and techniques that have been used by various researchers in the field of smart structures. Mathematical expressions of objective functions of twelve optimization criteria have been presented and their justifications have been reasoned. Step by step procedures of commonly used optimization techniques have also been presented.     

粉末橡胶

介绍了Adar自主研制的Aparene NBR胶粉的特性、加工方法。特别对其改性PVC和PF的优越性，分别用其鞋类、电气绝缘板、摩擦衬片等产品所体现出来的各项优异性能做出充分说明。其在橡胶工业上的应用以制作胶粘剂为例，阐述了使用胶粉可改革加工方法，摈弃密炼机，节省能源等诸多的优点。     

Sensitivities to early exchange in synchronous computer-supported collaborative learning (CSCL) groups

This study reports the impact of high sensitivity to early exchange in 11th-grade, CSCL triads solving well- and ill-structured problems in Newtonian Kinematics. A mixed-method analysis of the evolution of participation inequity (PI) in group discussions suggested that participation levels tended to get locked-in relatively early on in the discussion. Similarly, high (low) quality member contributions made earlier in a discussion did more good (harm) than those made later on. Both PI and differential impact of member contributions suggest a high sensitivity to early exchange; both significantly predicting the eventual group performance, as measured by solution quality. Consequently, eventual group performance could be predicted based on what happened in the first 30–40% of a discussion. In addition to drawing theoretical and methodological implications, implications for scaffolding CSCL groups are also discussed.