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81.
CM Tsai SH Hsiao CM Frey KT Chang RP Perng AF Gazdar BS Kramer 《Canadian Metallurgical Quarterly》1993,53(5):1079-1084
Both cisplatin (CDDP) and leucovorin (LV) have been shown to enhance cytotoxicity of 5-fluorouracil (FUra) against murine and human neoplasms by increasing intracellular reduced folate concentrations. We were interested in their use in a combination to inhibit non-small cell lung cancer (NSCLC) cell growth and therefore conducted an in vitro study to investigate the cytotoxic activities of combinations of CDDP plus FUra, with and without LV (20 microM), against seven NSCLC cell lines. A tetrazolium assay with application of the classical isobole method was used to test drug combinations. We found that LV enhanced FUra but not CDDP cytotoxicity and that the degree of enhancement was negatively correlated with the effect of FUra. There was an overall additive combination effect of CDDP plus FUra, although there may be synergy at higher effect levels. There was synergy to a combination of CDDP, FUra, and LV, presumably primarily related to the synergistic effects of adding LV to FUra. In summary, LV and CDDP enhanced FUra cytotoxicity in a complementary fashion and there was clear synergy of a combination of CDDP, FUra, and LV against a panel of NSCLC cell lines. Our in vitro results provide a rationale for controlled clinical studies of this three-drug regimen in patients with NSCLC. 相似文献
82.
本文根据ITU-T最新的Q.2971协议,以及笔者所从事的实际课题,提出一整套B-ISDN第三层UNI信令的软件实现策略,其特点是能同时满足用户对点到点以及点到多点广播这两种通信方式的要求,而且可以动态配置。 相似文献
83.
深过冷熔体激发快速定向凝固 总被引:11,自引:0,他引:11
阐述了深过冷的方法,深过冷的遗传性,深过冷度的理论极限以及深过冷熔体激发发快速定向凝固的试验方法及其凝固过程,给出了深过冷熔体(Cu-5wt%)激发快速定向凝固与铸态试验激发快速定向凝固的初步试验结果。 相似文献
84.
The changes in the intestinal mucosal permeability were observed by quantitatively assessing plasma to luminal clearance of 99mTc-labeled DTPA, and the influence of platelet activating factor (PAF) on it was investigated. The results showed that intestinal permeability was significantly elevated after severe burn and was positively correlated with increase in PAF in the intestinal tissue (r = 0.94, P < 0.01). PAF antagonist therapy could significantly attenuate postburn intestinal mucosal permeability. It is concluded that PAF is one of the important factors causing increased intestinal permeability after severe burn. 相似文献
85.
A new approach to 2-dimensional (2D) colour-image detection and matching using a modified version of the generalised Hough transform (GHT) is proposed. In the conventional GHT, the useful colour information existing in the input image and the relationship between each pixel and its neighbourhood are not used. Furthermore, lighting changes in the image are not usually considered. Therefore, the conventional GHT is seldom applied to colour images. In the proposed approach, lighting are removed using normalised colour values. Next, certain critical pixels of an input colour image whose neighbourhoods have larger variances of normalised colour values are extracted. For each critical pixel, a feature vector, which includes the normalised colour values of the pixel as well as those of the pixel's neighbours, is then constructed. A modified voting rule for the GHT is therefore proposed which is based on a similarity-measure function of the feature vectors. High maximum peaks in the cell array are searched finally as the result. The proposed method is robust for colour-image detection and matching in noisy, occlusive, and lighting-change environments, as demonstrated by experimental results 相似文献
86.
The quaternary alloy InAs1−x−ySbxPy, lattice-matched to InAs, is a promising material for the production of infrared light sources for the detection of gases
in the 2–4 μm region of the spectrum. In this work, thermodynamic phase equilibrium calculations have been carried out to
determine the compositions required for liquid phase epitaxial growth and the extent of the miscibility gap in the solid material.
For high band gap materials, the desired growth temperature is found to be intermediate between a low temperature required
to grow P-rich solids and higher temperatures required to avoidspinodal decomposition. Conventional LPE growth at an intermediate temperature of 583°C is found to produce good material with high
luminescence efficiency and excellent optical characteristics. Problems with phosphorus loss from the melt are also discussed
and lower growth temperatures are found to considerably reduce this problem. Growth in the metastable region between the binodal
and spinodal lines has been achieved with the production of phosphorus-rich solids with concentrations up to y = 0.445. 相似文献
87.
提出了用激光衍射功率谱方法测量柱形颗粒群直径分布的技术方法,解决了长颗粒随机排列时的功率谱探测,及数据快速优化方法等技术难题。此技术已地应用于由羊毛和化纤截成的柱形颗粒群直径分布的测量,实现结果证明了此技术的可行性和实用性。 相似文献
88.
Kuo-Kai Shyu Chiu-Keng Lai Yao-Wen Tsai Ding-I Yang 《Industrial Electronics, IEEE Transactions on》2002,49(3):558-565
A robust controller which is designed by employing variable-structure control and linear-quadratic method is presented for a permanent-magnet synchronous motor (PMSM) position control system. It is to achieve accurate control performance in the presence of plant parameter variation and load disturbance. In addition, it possesses the design flexibility of the conventional state feedback control. It is applied to the position control of a PMSM. Simulation and experimental results show that the proposed approach gives a better position response and is robust to parameter variations and load disturbance 相似文献
89.
本文针对结晶器与铸锭作相对移动的电渣重熔过程中对渣系的高温强度及塑性的要求,对10种CaF_2-CaO-MgO-Al_2O_3-SiO_2渣组成进行了渣的高温强度及塑性的测定,建立了渣组成—渣的岩相结构—渣高温强度及塑性间的对应关系,并选择出较合适的成分范围为CaF_2 35~60%,CaO 10~25%,Al_2O_3 10~20%,SiO_25~15%,MgO≈5%。对其中一个成分的渣进行了电渣热穿孔熔铸中空锭生产实验,并取得了良好的表面质量。 相似文献
90.
Steve H. Jen Bing J. Sheu Yoichi Oshima 《Analog Integrated Circuits and Signal Processing》1997,12(2):107-118
A unified single-equation approach for the MOS transistordrain current modeling for energy-efficient submicron MOS circuitsis presented. Instead of three sets of separate equations forthe triode, saturation, and weak inversion regions, only a continuousexpression which is valid to describe the behavior of drain currentand the derivatives in all operation regions can be realizedby using a combination of hyperbola, sigmoid, and interpolationmethods. The model expression can predict accurate results forthe current, output conductance, and transconductance with continuousand smooth characteristics. The simulation results agree wellwith experimental data. 相似文献