A Closed-Form Formula for the RBF-Based Approximation of the Laplace–Beltrami Operator

In this paper we present a method that uses radial basis functions to approximate the Laplace–Beltrami operator that allows to solve numerically diffusion (and reaction–diffusion) equations on smooth, closed surfaces embedded in \(\mathbb {R}^3\). The novelty of the method is in a closed-form formula for the Laplace–Beltrami operator derived in the paper, which involve the normal vector and the curvature at a set of points on the surface of interest. An advantage of the proposed method is that it does not rely on the explicit knowledge of the surface, which can be simply defined by a set of scattered nodes. In that case, the surface is represented by a level set function from which we can compute the needed normal vectors and the curvature. The formula for the Laplace–Beltrami operator is exact for radial basis functions and it also depends on the first and second derivatives of these functions at the scattered nodes that define the surface. We analyze the converge of the method and we present numerical simulations that show its performance. We include an application that arises in cardiology.     

Improving the Interoperability in the Digital Home Through the Automatic Generation of Software Adapters from a SysML Model

This paper addresses the motion planning problem of nonholonomic robotic systems. The system’s kinematics are described by a driftless control system with output. It is assumed that the control functions are represented in a parametric form, as truncated orthogonal series. A new motion planning algorithm is proposed based on the solution of a Lagrange-type optimisation problem stated in the linear approximation of the parametrised system. Performance of the algorithm is illustrated by numeric computations for a motion planning problem of the rolling ball.     

Quantitative structure-activity relationship studies for the prediction of antifungal activity of N-arylbenzenesulfonamides against Botrytis cinerea

The Botrytis cinerea is one of the most interesting fungal pathogens. It can infect almost every plant and plant part and cause early latent infections which damage the fruit before ripening. The QSAR is an alternative method for the research of new and better fungicides against B. cinerea. This paper describes the results of applying a topological sub-structural molecular design (TOPS-MODE) approach for predicting the antifungal activity of 28 N-arylbenzenesulfonamides. The model described 86.1% of the experimental variance, with a standard deviation of 0.223. Leave-one-out and leave-group-out cross validation was carried out with the aim of evaluating the predictive power of the model. The values of their respective squared correlations coefficients were 0.754 and 0.741. The TOPS-MODE approach was compared with three other predictive models, but none of these could explain more than 72.8% of the variance with the same number of variables. In addition, this approach enabled the assessment of the contribution of different bonds to antifungal activity, thereby making the relationships between structure and biological activity more transparent. It was found that the fungicidal activity of the chemicals analyzed was increased by the presence of a sulfonamide group bonded to two aromatics rings, making this group the most important of the molecule. The majority of the substituents present in the aromatic rings have an electron withdrawing effect and they contribute to a smaller degree than the sulfonamide group to the property under study. The aromatic moiety plays an important role in this activity; its contribution changes with different substituents. Generally, the nitro group has a positive and great contribution to the biological property but when this group is involved in some compounds in ortho effect with the SO2 moiety of the sulfonamide group a lower value of contribution is observed for both groups.     

Replacement techniques for dynamic NUCA cache designs on CMPs

The growing influence of wire delay in cache design has meant that access latencies to last-level cache banks are no longer constant. Non-Uniform Cache Architectures (NUCAs) have been proposed to address this problem. Furthermore, an efficient last-level cache is crucial in chip multiprocessors (CMP) architectures to reduce requests to the offchip memory, because of the significant speed gap between processor and memory. Therefore, a bank replacement policy that efficiently manages the NUCA cache is desirable. However, the decentralized nature of NUCA has eliminated the effectiveness of replacement policies because banks operate independently of each other, and hence their replacement decisions are restricted to a single NUCA bank. In this paper, we propose three different techniques to deal with replacements in NUCA caches.     

The bioleaching of different sulfide concentrates using thermophilic bacteria

The bioleaching of different mineral sulfide concentrates with thermophilic bacteria (genusSulfolobus @#@) was studied. Since the use of this type of bacteria in leaching systems involves stirring and the control of temperature, the influence of the type of stirring and the pulp density on dissolution rates was studied in order to ascertain the optimum conditions for metal recovery. At low pulp densities, the dissolution kinetic was favored by pneumatic stirring, but for higher pulp densities, orbital stirring produced the best results. A comparative study of three differential concentrates, one mixed concentrate, and one global concentrate was made. Copper and iron extraction is directly influenced by bacterial activity, while zinc dissolution is basically due to an indirect mechanism that is activated in the presence of copper ions. Galvanic interactions between the different sulfides favors the selective bioleaching of some phases (sphalerite and chalcopyrite) and leads to high metal recovery rates. However, the formation of galvanic couples depends on the type of concentrate.     

Effects of word linguistic properties on phonological awareness in Spanish children.

We investigated whether some word linguistic properties studied by R. Treiman and S. Weatherston (see record 1992-37025-001) in the English language have the same influence on phonological awareness of preschoolers and kindergartners in the Spanish language. We examined the effects of these word linguistic properties on children's ability to isolate the initial consonant: phoneme articulatory properties, the position of stressed syllables in the words, the presence of initial consonant clusters, and the word length. We found that effects due to word length and the syllable-initial consonant cluster were similar in English and Spanish. In contrast to English-speaking children, the Spanish-speaking children could pronounce the first consonant regardless of the position of the stressed syllable, and continuant consonants were easier to isolate than stop consonants. Implications for the training of phonological awareness in the Spanish language are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Kinase activity of oxygen sensor FixL depends on the spin state of its heme iron

FixL is a ferrous heme protein whose kinase activity is inhibited by oxygen. Here we show that met-FixL, which is the ferric unliganded form, has the same activity as deoxy-FixL, the ferrous unliganded form, indicating that activity does not depend on the oxidation state of the heme iron. The ferric derivative fluoro-FixL is fully active, indicating that the presence of a heme ligand is not sufficient to cause kinase inhibition. An inverse relation between the rate of autophosphorylation of ferric FixL and the fractional saturation with cyanide shows that the cyanomet form has zero activity. All our active derivatives were high-spin, while our inactive derivatives were low-spin. In mixtures of high- and low-spin FixL, resulting from partial saturation with low-spin ligands, the activity was that which would be expected for the concentration of the high-spin component alone. Therefore the spin state of the heme iron rather than the oxidation state or presence of ligands must be the factor that controls FixL's kinase activity. On transition from low to high spin, the heme iron moves out of the porphyrin plane by 0.4 A. We propose that, as in hemoglobin, this motion triggers a long-range conformational change which in FixL is responsible for a switch to an active form.     

Gastrointestinal leishmaniasis in human immunodeficiency virus-infected patients: report of five cases and review

We describe five cases of gastrointestinal leishmaniasis in patients with human immunodeficiency virus infection and review 10 additional cases reported in the literature. All of the patients had CD4+ cell counts of < 200/mm3, and AIDS had been previously diagnosed for 12 patients. Fever and splenomegaly were present in 46% of cases. Thirteen patients had digestive symptoms; these symptoms included diarrhea (6), dysphagia and/or odynophagia (6), abdominal pain (2), epigastric pain (2), gastrointestinal hemorrhage (1), and rectal discomfort (1). The regions of the digestive tract most frequently affected by Leishmania organisms were the duodenal mucosa (90%) and the gastric mucosa (75%). Endoscopy showed normal-appearing mucosa in 45% of cases. In 10 cases the diagnosis of visceral leishmaniasis was first made by biopsy of the gastrointestinal mucosa. In most cases treatment with antimonial agents was not effective.     

Triplet and quadruplet pregnancy: management and perinatal outcome

The frequency of multiple pregnancies with more than two fetuses has increased considerably since the introduction of methods of ovulation induction, in vitro fertilization, and embryo transfer. We have analyzed the evolution, complications, delivery and perinatal outcome of 23 triplet and 3 quadruplet pregnancies occurred during a four-year period in one medical center. The most frequent complication was preterm labor (62%). The mean gestational age at delivery was 32.5 weeks for the quadruplets and 31.5 weeks for the triplets and the mean birth weight was 1461 and 1526 for quadruplets and triplets, respectively. Perinatal mortality for the whole group was 148/1000.