Cubic polynomial patches through geodesics

We consider patches that contain any given 3D polynomial curve as a pregeodesic (i.e. geodesic up to reparametrization). A curve is a pregeodesic if and only if its rectifying plane coincides with the tangent plane to the surface, we use this fact to construct ruled cubic patches through pregeodesics and bicubic patches through pairs of pregeodesics. We also discuss the G¹ connection of (1,k) patches with abutting pregeodesics.     

Effect of treatment with 13-cis-retinoic acid and ara-C on the hematopoietic stem cells of patients with myelodysplastic syndromes

PURPOSE: To assess the "in vivo" effect of 13-cis-retinoic acid and low dose Ara-C in MDS as well as to establish "in vitro" advantage of retinoid dose-related growth pattern on bone marrow cultures as defined by culture timing and CFU-GM proliferative response. PATIENTS AND METHODS: We evaluated 28 patients diagnosed of MDS according to FAB classification, of whom 4 cases had RA, 8 cases SRA, 14 cases RAEB and 2 cases RAEB-T. Patients who had RA and SRA were treated with oral 13-cis-retinoic acid at doses of 20-40 mg daily for 4 months and those cases with RAEB and RAEB-T had subcutaneous Ara-C at doses of 3 mg/m2 twice a day for 21 days. The "in vivo" and "in vitro" effect of retinoic acid on the haemopoietic differentiation was evaluated by the growth CFU-GM in semisolid cell culture methods. RESULTS: Increasing in vitro concentrations of 13-cis retinoic acid did not enhance the growth of myelodysplastic progenitors. Nevertheless, our study did not find any beneficial therapeutic effect of retinoic compounds in MDS patients. In this study, low-dose Ara-C (3 mg/m2) showed similar effects when compared with higher doses reported by others. Furthermore, in terms of CFU-GM proliferation the concentration of colonies before and after treatment were fairly similar in all but two patients. CONCLUSIONS: The results drawn from our study demonstrated that there is no beneficial advantage of 13-cis-retinoic acid as a differentiation inducing agent on myelodysplastic patients. In contrast, lower doses of Ara-C showed similar effects on haemopoiesis of MDS patients than standard doses of 10-20 mg/m2 but with less side effects.     

Combined analytical solution of overland flow and sediment transport

With reference to the kinematic wave theory coupled with the hypothesis of constant linear velocity for the rating curve, rising limb analytical solutions have been calculated for overland flow, over an Hortonian-infiltrating surface, and sediment discharge. These analytical solutions are certainly easier to use than the numerical integration of the basic equations and they may be used to obtain an initial evaluation of the parameters of more complex models generally devised for complicated cases.Notation a exponent of the Horton law [T^–1] - b exponent of the rill erosion equation - B inter-rill erosion coefficient [ML^–m–2T ^m–1] - c sediment concentration [ML^–3] - c _o reference sediment concentration [ML^–3] - E _I inter-rill erosion [ML^–2T^–1] - E _R rill erosion [ML^–2T^–1] - f _c final infiltration rate of the soil [LT^–1] - f _o initial infiltration rate of the soil [LT^–1] - h flow depth [L] - h _o reference flow depth [L] - i infiltration rate [LT^–1] - k rill erosion coefficient [ML^–1–b T^–1] - K integration constant - L() Laplace transformation - m exponent of the inter-rill erosion equation - n Manning's coefficient [L^–1/3T] - p rainfall intensity [LT^–1] - q water discharge per unit width [L²T^–1] - q _s sediment discharge per unit width [ML^–1T^–1] - t time [T] - t _p ponding time [T] - x distance along the flow direction [L] Greek Letters coefficient of the stage-discharge equation [L^2–T^–1] - exponent of the stage-discharge equation - rill erosion coefficient [L^–1]     

Temperatures in linguistics as a model of thermodynamics

Natural languages have been taken as models of systems with strong statistical correlations. In such systems the usual probabilistic limiting laws (Gauss etc.) are no more valid and the concept of higher order temperatures can be applied. It has been shown that this is the case in such languages as English, German, French, Russian and Japanese, for letter and word statistics. The corresponding temperatures (up to the 5-th order), entropies and statistical moments have been calculated and their mutual relations have been checked.... erst wenn du plötzlich Fänger wirst des Balles, den eine ewige Mitspielerin dir zuwarf, ... erst dann ist Fangen-können ein Vermögen, nicht deines, einer Welt.(... only when you suddenly catch the ball which the eternal fellow player throws to you,... only then the catching ability is an accomplishment, not of you, but of the world.)R. M. Rilke (from the motto of [3])Supported by Committee of Scientific Research, Warsaw (KBN), Project Nr. 20412 91 01.     

Recent Advances on High-Speed and Holographic Two-Photon Direct Laser Writing

Two-Photon Lithography, thanks to its very high sub-diffraction resolution, has become the lithographic technique par excellence in applications requiring small feature sizes and complex 3D pattering. Despite this, the fabrication times required for extended structures remain much longer than those of other competing techniques (UV mask lithography, nanoimprinting, etc.). Its low throughput prevents its wide adoption in industrial applications. To increase it, over the years different solutions have been proposed, although their usage is difficult to generalize and may be limited depending on the specific application. A promising strategy to further increase the throughput of Two-Photon Lithography, opening a concrete window for its adoption in industry, lies in its combination with holography approaches: in this way it is possible to generate dozens of foci from a single laser beam, thus parallelizing the fabrication of periodic structures, or to engineer the intensity distribution on the writing plane in a complex way, obtaining 3D microstructures with a single exposure. Here, the fundamental concepts behind high-speed Two-Photon Lithography and its combination with holography are discussed, and the literary production of recent years that exploits such techniques is reviewed, and contextualized according to the topic covered.     

FreesoundVR: soundscape composition in virtual reality using online sound repositories

Virtual Reality - The intersection between sound and music computing and Virtual Reality (VR) has grown significantly over the past decades, amounting to an established area of research today....     

Robust linear quadratic regulator applied to an inverted pendulum

The natural instability of an inverted pendulum and its dynamics richness, in terms of nonlinearity, provide a nice apparatus to reproduce behaviors of analogous systems. In this way, it is useful to perform benchmark tests for new control approaches developed. In this paper, we address the main inverted pendulum problems: pendulum stabilization, tracking, and catching swing-up control. We show how robust recursive, control and filtering, techniques improve the system performance. They are developed to solve stochastic problems based on deterministic approaches, in order to decrease the worst influence of uncertainties. Experimental results of the proposed robust approach provide robust stability and performance despite parametric uncertainties, disturbances, and noise effects.     

Modelling and condition-based control of a flexible and hybrid disassembly system with manual and autonomous workstations using reinforcement learning

Journal of Intelligent Manufacturing - Remanufacturing includes disassembly and reassembly of used products to save natural resources and reduce emissions. While assembly is widely understood in...     

Photonic-aware neural networks

Neural Computing and Applications - Photonics-based neural networks promise to outperform electronic counterparts, accelerating neural network computations while reducing power consumption and...     

An empirical evaluation of active learning strategies for profile elicitation in a conversational recommender system

Journal of Intelligent Information Systems - Conversational Recommender Systems have received widespread attention in both research and practice. They assist people in finding relevant and...