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This report summarizes the panel held at the annual meeting of the American Psychological Association, Division 39 (Psychoanalysis). The panel explored the meaning of desire in childhood, adolescence, and adulthood. The discussants focused on the subjective experience of desire, its preconditions, and its significance in different developmental stages. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Jeffrey Krivis and Mariam Zadeh, of Los Angeles, focus on communication styles in order to improve settlements. The authors provide four tables of keywords that identify the way people get their points across. These signals allow negotiators to meet their adversaries on their opponents' terms, and provide improved results for their own clients. 相似文献
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Kristine K. Deibler Dr. Gary E. Schiltz Dr. Matthew R. Clutter Dr. Rama K. Mishra Purav P. Vagadia Dr. Matthew O'Connor Mariam Donny George Dr. Ryan Gordon Graham Fowler Dr. Raymond Bergan Prof. Karl A. Scheidt 《ChemMedChem》2019,14(6):615-620
Herein we report the discovery of a novel series of highly potent and selective mitogen-activated protein kinase kinase 4 (MEK4) inhibitors. MEK4 is an upstream kinase in MAPK signaling pathways that phosphorylates p38 MAPK and JNK in response to mitogenic and cellular stress queues. MEK4 is overexpressed and induces metastasis in advanced prostate cancer lesions. However, the value of MEK4 as an oncology target has not been pharmacologically validated because selective chemical probes targeting MEK4 have not been developed. Optimization of this series via structure–activity relationships and molecular modeling led to the identification of compound 6 ff (4-(6-fluoro-2H-indazol-3-yl)benzoic acid), a highly potent and selective MEK4 inhibitor. This series of inhibitors is the first of its kind in both activity and selectivity and will be useful in further defining the role of MEK4 in prostate and other cancers. 相似文献
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A multiclass 3D object recognition has perceived a numerous evolution with respect to both accuracy and speed. This study introduces the implementation of modern YOLO algorithms (YOLOv3, YOLOv4, and YOLOv5) for multiclass 3D object detection and recognition. All YOLO algorithms have been tested according to a very large scaled dataset (Pascal VOC dataset). Performance evaluation has targeted the calculation of the following metrics; mAP (mean average precision), recall, F1-score, IOU (intersection over union), and the running time. Experimental results demonstrate that the YOLOv3 has targeted mAP of 77%, IOU of 0.41 and the total running time was almost 8 h. Moreover, in YOLOv4, it has targeted mAP of 55%, IOU of 0.035 and the total running time nearly 7 h. In addition, YOLOv5 has established the mAP of 48%, IOU of 0.045, and the total running time was about 3 h. Finally, a modified version of YOLOv5 has been proposed in the state-of-the-art of optimizing its hyperparameters and layering system. Accordingly, the mAP scored about 55% with 3 h running time. The final conclusions of this study have demonstrated that YOLOv3 has scored the highest recognition accuracy, however, the proposed modified YOLOv5 has scored the least processing time. 相似文献
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Svetlana A. Sorokina Stepan P. Mikhailov Nina V. Kuchkina Alexey V. Bykov Alexander L. Vasiliev Mariam G. Ezernitskaya Andrey L. Golovin Linda Zh. Nikoshvili Mikhail G. Sulman Zinaida B. Shifrina 《International journal of molecular sciences》2022,23(2)
Hydrogenation of levulinic acid (LA) obtained from cellulose biomass is a promising path for production of γ-valerolactone (GVL)—a component of biofuel. In this work, we developed Ru nanoparticle containing nanocomposites based on hyperbranched pyridylphenylene polymer, serving as multiligand and stabilizing matrix. The functionalization of the nanocomposite with sulfuric acid significantly enhances the activity of the catalyst in the selective hydrogenation of LA to GVL and allows the reaction to proceed under mild reaction conditions (100 °C, 2 MPa of H2) in water and low catalyst loading (0.016 mol.%) with a quantitative yield of GVL and selectivity up to 100%. The catalysts were successfully reused four times without a significant loss of activity. A comprehensive physicochemical characterization of the catalysts allowed us to assess structure-property relationships and to uncover an important role of the polymeric support in the efficient GVL synthesis. 相似文献
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