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31.
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Filippo Giannazzo Salvatore Ethan Panasci Emanuela Schilirò Patrick Fiorenza Giuseppe Greco Fabrizio Roccaforte Marco Cannas Simonpietro Agnello Antal Koos Béla Pécz Marianna Španková Štefan Chromik 《Advanced Materials Interfaces》2023,10(1):2201502
In this paper, 2D/3D heterojunction diodes have been fabricated by pulsed laser deposition (PLD) of MoS2 on 4H-SiC(0001) surfaces with different doping levels, i.e., n− epitaxial doping (≈1016 cm−3) and n+ ion implantation doping (>1019 cm−3). After assessing the excellent thickness uniformity (≈3L-MoS2) and conformal coverage of the PLD-grown films by Raman mapping and transmission electron microscopy, the current injection across the heterojunctions is investigated by temperature-dependent current–voltage characterization of the diodes and by nanoscale current mapping with conductive atomic force microscopy. A wide tunability of the transport properties is shown by the SiC surface doping, with highly rectifying behavior for the MoS2/n− SiC junction and a strongly enhanced current injection for MoS2/n+ SiC one. Thermionic emission is found the dominant mechanism ruling forward current in MoS2/n− SiC diodes, with an effective barrier ΦB = (1.04 ± 0.09) eV. Instead, the significantly lower effective barrier ΦB = (0.31 ± 0.01) eV and a temperature-dependent ideality factor for MoS2/n+ SiC junctions is explained by thermionic-field-emission through the thin depletion region of n+ doped SiC. The scalability of PLD MoS2 deposition and the electronic transport tunability by implantation doping of SiC represents key steps for industrial development of MoS2/SiC devices. 相似文献
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34.
Shengfu Yang Cheng Feng Daniel Spence Aula M. A. A. Al Hindawi Elspeth Latimer Andrew M. Ellis Chris Binns Davide Peddis Sarnjeet S. Dhesi Liying Zhang Yafei Zhang Kalliopi N. Trohidou Marianna Vasilakaki Nikolaos Ntallis Ian MacLaren Frank M. F. de Groot 《Advanced materials (Deerfield Beach, Fla.)》2017,29(1)
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36.
Marianna Rossetti Lorenzo Stella Judit Morlà-Folch Sara Bobone Ariadna Boloix Lorena Baranda Danila Moscone Mònica Roldán Jaume Veciana Miguel F. Segura Mariana Köber Nora Ventosa Alessandro Porchetta 《Advanced functional materials》2021,31(46):2103511
The development of artificial vesicles into responsive architectures capable of sensing the biological environment and simultaneously signaling the presence of a specific target molecule is a key challenge in a range of biomedical applications from drug delivery to diagnostic tools. Herein, the rational design of biomimetic DNA-grafted quatsome (QS) nanovesicles capable of translating the binding of a target molecule to amphiphilic DNA probes into an optical output is presented. QSs are synthetic lipid-based nanovesicles able to confine multiple organic dyes at the nanoscale, resulting in ultra-bright soft materials with attractiveness for sensing applications. Dye-loaded QS nanovesicles of different composition and surface charge are grafted with fluorescent amphiphilic nucleic acid-based probes to produce programmable FRET-active nanovesicles that operate as highly sensitive signal transducers. The photophysical properties of the DNA-grafted nanovesicles are characterized and the highly selective, ratiometric detection of clinically relevant microRNAs with sensitivity in the low nanomolar range are demonstrated. The potential applications of responsive QS nanovesicles for biosensing applications but also as functional nanodevices for targeted biomedical applications is envisaged. 相似文献
37.
Maria Serena Maglione Stefano Casalini Stamatis Georgakopoulos Marianna Barbalinardo Vitaliy Parkula Núria Crivillers Concepció Rovira Pierpaolo Greco Marta Mas‐Torrent 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(10)
A switchable electrode, which relies on an indium‐tin oxide conductive substrate coated with a self‐assembled monolayer terminated with an anthraquinone group (AQ), is reported as an electrowetting system. AQ electrochemical features confer the capability of yielding a significant modulation of surface wettability as high as 26° when its redox state is switched. Hence, an array of planar electrodes for droplets actuation is fabricated and integrated in a microfluidic device to perform mixing and dispensing on sub‐nanoliter scale. Vehiculation of cells across microfluidic compartments is made possible by taking full advantage of surface electrowetting in culture medium. 相似文献
38.
João P. Martins Roberto D'Auria Dongfei Liu Flavia Fontana Mónica P. A. Ferreira Alexandra Correia Marianna Kemell Karina Moslova Ermei Mäkilä Jarno Salonen Luca Casettari Jouni Hirvonen Bruno Sarmento Hélder A. Santos 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(27)
The last decade has seen remarkable advances in the development of drug delivery systems as alternative to parenteral injection‐based delivery of insulin. Neonatal Fc receptor (FcRn)‐mediated transcytosis has been recently proposed as a strategy to increase the transport of drugs across the intestinal epithelium. FcRn‐targeted nanoparticles (NPs) could hijack the FcRn transcytotic pathway and cross the epithelial cell layer. In this study, a novel nanoparticulate system for insulin delivery based on porous silicon NPs is proposed. After surface conjugation with albumin and loading with insulin, the NPs are encapsulated into a pH‐responsive polymeric particle by nanoprecipitation. The developed NP formulation shows controlled size and homogeneous size distribution. Transmission electron microscopy (TEM) images show successful encapsulation of the NPs into pH‐sensitive polymeric particles. No insulin release is detected at acidic conditions, but a controlled release profile is observed at intestinal pH. Toxicity studies show high compatibility of the NPs with intestinal cells. In vitro insulin permeation across the intestinal epithelium shows approximately fivefold increase when insulin is loaded into FcRn‐targeted NPs. Overall, these FcRn‐targeted NPs offer a toolbox in the development of targeted therapies for oral delivery of insulin. 相似文献
39.
Francesco Decataldo Marianna Barbalinardo Marta Tessarolo Vito Vurro Maria Calienni Denis Gentili Francesco Valle Massimiliano Cavallini Beatrice Fraboni 《Advanced Materials Technologies》2019,4(9)
Current technologies to monitor formation and disruption in in vitro cell cultures are based either on optical techniques or on electrical impedance/resistance measurement, which often rely on cumbersome and time‐consuming measurements and data analyses. In this paper, poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS)‐based organic electrochemical transistors (OECTs) are proposed with channel areas specifically designed and dimensioned as fast and real‐time monitoring devices for a large variety of cell lines, with a broad range of tissue resistance. In particular, it is investigated how and why two device configurations provide a different response to leaky‐barrier (NIH‐3T3) and strong‐barrier (CaCo‐2) cell lines growth and detachment, achieving a continuous monitoring also for leaky‐barrier cell layer growth and detachment. Data are collected using the transistor dynamic behavior to a DC potential pulse on the gate, providing an excellent time resolution and thus enhancing the amount of information that can be collected for fast biological processes (<5 s). 相似文献
40.
Suzane Lucas Schechtel Vanessa Cristina Rodrigues de Matos Jnio Sousa Santos Thiago Mendanha Cruz Mariza Boscacci Marques Mingchun Wen Liang Zhang Marianna Miranda Furtado Anderson S. Sant'Ana Mariana Araújo Vieira do Carmo Luciana Azevedo Jssica Caroline Bigaski Ribeiro Daniel Granato 《Journal of food science》2019,84(12):3473-3482