Preparation and physico-chemical characterisation of microporous polysaccharidic hydrogels

A new technique to obtain microporous hydrogels was realised. It permits us to obtain a microporous structure directly on the already cross-linked hydrogel. It consists in stratifying the already cross-linked hydrogel on to a filter with known porosity and forcing the CO2 bubbles, derived from the addition of HCl to a porogen salt (NaHCO3), to cross through the filter first and then the matrix. By changing the porosity of the filter, it was possible to modulate the porous morphology of the hydrogels. The polysaccharides selected were hyaluronane, alginate, and carboxymethylcellulose. The influence of the porous morphology on the physico-chemical properties of the gel has been evaluated by FT-IR, FRAP, calorimetric, water uptake, and rheological analysis.     

Closed-Form Expressions for the Electromagnetic Radiation of Microstrip Signal Traces

An analytical study of the unintentional electromagnetic radiation of a microstrip signal trace is presented. Based on transmission-line theory and appropriate far-field Green's functions, a closed-form solution for the electric field is developed, including the contribution from the vertical terminal connections. It allows calculating the frequency and directional response of the radiated emission, depending on the material and geometrical parameters and terminal load impedances. For the special case of matched termination, the general solution assumes a compact form, allowing to set up a formula for the peak-amplitude frequencies. It is shown that in the higher frequency region, where the wavelength is comparable or shorter than the line length, the frequency-response envelope continuously rises with 20 dB/dec. Based on appropriate simplifications, the asymptotic solution for the electrically short line is deduced, including a practical formula for the maximum electric field. It is found that the usual small-current-loop (magnetic-dipole) estimation is incomplete due to the omission of the electric-dipole contribution.     

Knowledge representation of the software architecture design process based on situation calculus

Software architecture design is an interactive, complex, decision‐making process. Such a design process involves the exploration, evaluation, and composition of design alternatives. Increasingly, new computer‐aided tools are available to help designers in these complex activities. However, these tools do not know how design is actually done, in other words, by means of which design activities the final artefact was obtained. In fact, the architectural design knowledge exclusively rests in the mind of designers, and there is an urgent need to move it, as much as possible, to a computer‐supported environment that enables the capture of this type of knowledge. This contribution addresses this need by introducing a model for capturing how products under development are generated and transformed along the software architecture design process. The proposed model follows an operational perspective, where architectural design decisions are modelled by means of sequences of operations that are applied on the design products. Situation calculus is used to formally express the existence of an object in a given state of a design process. In addition, this formalism allows us expressing without ambiguities when an operation can be performed in a specific state of the design process.     

HLA antigens and erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Sardinia

Wind enhances the carcinogenic effect of chronic Iltraviolet radiation (UVL). This was demonstrated in hairless mice that were irradiated for 42 weeks with mercury are lamps. One group of animals was exposed to continuous wind flow of 2.7 m/s except for the daily I-2 min time interval when they were removed from the wind tunnel and irradiated. Another group of animals received identical irradiation but were protected from wind. The first tumour appeared in the UVL and wind group after 105 days of irradiation, and at 164 days of irradiation all surviving mice in the group had developed tumours. The group of mice receiving identical irradiation but protected from wind had their first tumour appear at 154 days of irradiation, and by 164 days of irradiation only 40% of the mice had developed tumours.     

Targeted Therapies for Brain Metastases from Breast Cancer

The discovery of various driver pathways and targeted small molecule agents/antibodies have revolutionized the management of metastatic breast cancer. Currently, the major targets of clinical utility in breast cancer include the human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) receptor, mechanistic target of rapamycin (mTOR) pathway, and the cyclin-dependent kinase 4/6 (CDK-4/6) pathway. Brain metastasis, however, remains a thorn in the flesh, leading to morbidity, neuro-cognitive decline, and interruptions in the management of systemic disease. Approximately 20%–30% of patients with metastatic breast cancer develop brain metastases. Surgery, whole brain radiation therapy, and stereotactic radiosurgery are the traditional treatment options for patients with brain metastases. The therapeutic paradigm is changing due to better understanding of the blood brain barrier and the advent of tyrosine kinase inhibitors and monoclonal antibodies. Several of these agents are in clinical practice and several others are in early stage clinical trials. In this article, we will review the common targetable pathways in the management of breast cancer patients with brain metastases, and the current state of the clinical development of drugs against these pathways.     

Far-field pattern determination from the near-field amplitude ontwo surfaces

The possibility of determining the far field of radiating systems by measuring only the near-field amplitude is investigated. The main difficulties of the problem are examined in some detail and a new near-field/far-field transformation technique is developed, based on the measurement of the near-field amplitude over two surfaces surrounding the antenna under test. The accuracy of the far-field reconstruction results are related both to the distance between such surfaces and to some a priori information concerning the near-field phase and/or the radiating system. The information on the radiating system allows relaxation of the need for any information on the near-field phase provided that the distance between the measurement surfaces is high enough. Conversely, the knowledge of a more or less corrupted near-field phase allows reduction of such distances without affecting the accuracy of the far-field reconstruction. Numerical examples validating the effectiveness of the developed algorithm are provided for the planar scanning case     

On the electromagnetic radiation of printed-circuit-board interconnections

Large ground and supply layers on interconnected boards represent a radiating antenna structure which may be efficiently excited at its resonances by small high-frequency potential differences. Such potential differences between the boards mainly originate from the inevitable inductive impedance of the signal-current return path in the connector, usually provided by ground pins. The presented modeling approach is based on an antenna transfer function for the global interconnecting structure and a partial-inductance equivalent circuit for the connector. As shown by the example of a motherboard-daughterboard structure, the model enables a systematic study of the radiation mechanism, depending on signal/ground-pin configuration, as well as geometrical and electrical parameters. In conjunction with SPICE simulations of the connector equivalent circuit, the signal driver and receiver dynamic characteristic can also be properly included. Validation is provided by full-wave simulation and measurement results.