RhG-CSF-mobilized CD34+ peripheral blood progenitors are myeloperoxidase-negative and noncycling irrespective of CD33 or CD13 coexpression

OBJECTIVE: The purpose of this study was to differentiate between the catabolic effects of interleukin-1 (IL-1) when infused into the central nervous system or into the periphery. SUMMARY BACKGROUND DATA: After injury and infection, IL-1 has been found in the central nervous system. Chronic intracerebrovascular infusion of IL-1 produces protein catabolism, anorexia, and fever. However, IL-1 may act directly on liver and bone marrow to elicit metabolic responses. Although IL-1 is thought to be involved in a number of metabolic responses associated with injury-inflammation, the sites of action are unclear. METHODS: Rats were implanted with chronic infusion pumps and received diluent or three doses of IL-1 infused subcutaneously for 6 days, and a variety of response variables were measured. In a second study, doses were adjusted so that similar systemic catabolic responses were obtained from peripheral and intracerebroventricular infusion of IL-1. The acute-phase responses then were compared in the two groups of animals receiving IL-1 by different routes. RESULT: Subcutaneously infused IL-1 elicited catabolic responses in a dose-response manner. Similar catabolic responses were achieved by infusing one tenth of the dose of IL-1 given subcutaneously into the central nervous system. Although similar systemic responses (protein catabolism, anorexia, fever, and weight loss) were observed with both routes of infusion, the subcutaneous infusion produced a much greater lymphocytosis, elevation in acute-phase reactants, and fall in serum iron and albumin. CONCLUSIONS: The IL-1 appears to have different effects depending on the site of production and site of action. Regionalization of signal proteins such as IL-1 should be taken into consideration when devising specific anticytokine treatment strategies.     

Evaluation of continuous measurement of cardiac output with thermodilution in critical patients

Pregnant women with inflammatory bowel disease and their physicians should be aware of factors that may affect the outcome of the pregnancy. Proper patient education, along with a physician team approach, usually ensure completion of an uneventful pregnancy.     

The direct fluorination of a porous functionalized polymer

Macroporous sulfonated polystyrene ion exchange resin was reacted with elemental fluorine in a liquid-phase suspension reactor at low temperature. This method gave retention of the bulk structure of the resin bead and resulted in a space-selective distribution of fluorine across the resin bead cross-section, as determined using ¹⁹F secondary ion mass spectroscopy (LMI-SIMS). The polymer modification was additionally characterized using x-ray photoelectron spectroscopy, photoacoustic IR spectrophotometry, ¹⁹F, and ¹³C MAS NMR spectrometry, and mercury porosimetry. © 1994 John Wiley & Sons, Inc.     

A compensation technique for positioning errors in planarnear-field measurements

Probe positioning errors are among the major sources of inaccuracy in the planar near-field-far-field transformation technique, as their presence destroys the Fourier-transform relationship between the tangential components of the near field and those of the plane-wave spectrum of the test antenna. An optical systematic correction technique is developed which requires only the knowledge of the true probe positions. The `corrected' values are computed by an iterative procedure which turns out to be rapidly convergent and fairly accurate even in the presence of rather high displacement errors. It is concluded that the developed correction technique either includes or compares favorably with alternative methods. It is an optimal generalization of the Z -correction method, being exact in principle and allowing simple control of the attainable precision