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91.
Haile Ma Zhongli Pan Baoguo Li Griffiths G. Atungulu Donald A. Olson Marisa M. Wall Tara H. McHugh 《LWT》2012,46(1):326-334
It is vital to process breadfruit in order to develop new value-added products with improved sensory and physicochemical characteristics. In this research, dried breadfruit was extruded with a twin screw extruder and effects of barrel temperature, moisture content, feeding rate and screw speed on product physicochemical properties and process energy consumption were studied. Quadratic models were obtained to predict the product quality under various processing conditions. The best range of crispness of the extrudate was from 2.0 to 3.5N/s, hardness from 60 to 75 N and bulk density from 0.3 to 0.38 g/cm3. Corresponding operating conditions of feeding rate, temperature, screw speed and moisture content to obtain best results of crispness, hardness and bulk density were 16 kg/h, 130 °C, 160 rpm, 22 g/100 g; 22 kg/h, 150 °C, 160rpm, 22 g/kg; 19 kg/h, 140 °C, 115 rpm, 19 g/100 g; and 25 kg/h, 140 °C, 145 rpm, 19 g/100 g, respectively. The linear term of screw speed significantly effected all indexes (p < 0.001), especially water absorption and solubility indexes, sectional expansion ratio, bulk density, color and specific mechanical energy. The interaction term of feed rate and temperature, and square term of screw speed had no significant influences (p ≥ 0.1). The findings were useful for developing and optimizing extruded or value-added co products of breadfruit. 相似文献
92.
Paolo Sportoletti Filomena De Falco Beatrice Del Papa Stefano Baldoni Valerio Guarente Andrea Marra Erica Dorillo Chiara Rompietti Francesco Maria Adamo Loredana Ruggeri Mauro Di Ianni Emanuela Rosati 《International journal of molecular sciences》2021,22(13)
Key features of chronic lymphocytic leukemia (CLL) are defects in the immune system and the ability of leukemic cells to evade immune defenses and induce immunosuppression, resulting in increased susceptibility to infections and disease progression. Several immune effectors are impaired in CLL, including T and natural killer (NK) cells. The role of T cells in defense against CLL and in CLL progression and immunotherapy has been extensively studied. Less is known about the role of NK cells in this leukemia, and data on NK cell alterations in CLL are contrasting. Besides studies showing that NK cells have intrinsic defects in CLL, there is a large body of evidence indicating that NK cell dysfunctions in CLL mainly depend on the escape mechanisms employed by leukemic cells. In keeping, it has been shown that NK cell functions, including antibody-dependent cellular cytotoxicity (ADCC), can be retained and/or restored after adequate stimulation. Therefore, due to their preserved ADCC function and the reversibility of CLL-related dysfunctions, NK cells are an attractive source for novel immunotherapeutic strategies in this disease, including chimeric antigen receptor (CAR) therapy. Recently, satisfying clinical responses have been obtained in CLL patients using cord blood-derived CAR-NK cells, opening new possibilities for further exploring NK cells in the immunotherapy of CLL. However, notwithstanding the promising results of this clinical trial, more evidence is needed to fully understand whether and in which CLL cases NK cell-based immunotherapy may represent a valid, alternative/additional therapeutic option for this leukemia. In this review, we provide an overview of the current knowledge about phenotypic and functional alterations of NK cells in CLL and the mechanisms by which CLL cells circumvent NK cell-mediated immunosurveillance. Additionally, we discuss the potential relevance of using NK cells in CLL immunotherapy. 相似文献
93.
The influence of drying air temperature on the physical properties of dried and rehydrated eggplant 总被引:1,自引:0,他引:1
Paola Russo Giuseppina Adiletta Marisa Di Matteo 《Food and Bioproducts Processing》2013,91(3):249-256
Drying processes generally cause volume and surface change of foodstuffs. Information on the porous structure and the mechanical properties of dried food products is needed for determining food quality, process design and estimating properties such as density and moisture diffusivity.In this work we investigated the structural changes induced in eggplant by convective air drying at four different temperatures (40, 50, 60 and 70 °C) and their effect on the subsequent rehydration process. Drying and rehydration kinetic curves were also measured.The changes in physical properties, such as porosity, pore-size distribution and bulk density were determined by Hg porosimetry, scanning electron microscopy and optical microscopy while their effect on the textural characteristics by dynamometric measurements.As expected, the increase of the drying air temperature causes shorter drying times. The drying temperature influences strongly the microstructure of dried samples: the porosity increases with the air temperature, but the structure is better preserved at intermediate temperature (60 °C) as confirmed by the lower firmness values with respect to the other dehydrated samples (40, 50 and 70 °C). In these latter, the longer drying time and the higher temperature, respectively, causes the development of a wrinkled structure. In particular, at 70 °C the structure of dehydrated samples appears totally broken with a consequent faster water uptake during rehydration. 相似文献
94.
Maria Jos O. C. Guimares Fernanda M. B. Coutinho Marisa C. G. Rocha Maria Elizabeth F. Garcia 《应用聚合物科学杂志》2001,81(8):1991-1995
Mechanical, thermal, and morphological properties of blends of high density polyethylene and poly(ethylene‐co‐1‐octene) (PEO) were evaluated. The blends were prepared in a single screw extruder at 230°C and 50 rpm with volume fraction of elastomer varying in the range from 0.05 to 0.8. Factors such as chemical similarity and melt viscosity favor the interdiffusion process of phases, resulting in better interfacial adhesion. A synergistic effect on the strength at break and elongation at break for a particular range of blend composition was observed. Blends with a volume fraction of PEO higher than 5% presented a super tough behavior at room temperature. Thermal analysis showed that there is a certain degree of interaction between high density polyethylene and PEO. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 81: 1991–1995, 2001 相似文献
95.
Effect of a nonionic surfactant on biodegradation of slowly desorbing PAHs in contaminated soils 总被引:2,自引:0,他引:2
The influence of the nonionic surfactant Brij 35 on biodegradation of slowly desorbing polycyclic aromatic hydrocarbons (PAHs) was determined in contaminated soils. We employed a soil originated from a creosote-polluted site, and a manufactured gas plant soil that had been treated by bioremediation. The two soils differed in their total content in five indicator 3-, 4-, and 5-ring PAHs (2923 mg kg(-1) and 183 mg kg(-1) in the creosote-polluted and bioremediated soils, respectively) but had a similar content (140 mg kg(-1) vs 156 mg kg(-1)) of slowly desorbing PAHs. The PAHs present in the bioremediated soil were highly recalcitrant. The surfactant at a concentration above its critical micelle concentration enhanced the biodegradation of slowly desorbing PAHs in suspensions of both soils, but it was especially efficient with bioremediated soil, causing a 62% loss of the total PAH content. An inhibition of biodegradation was observed with the high-molecular-weight PAHs pyrene and benzo[a]pyrene in the untreated soil, possibly due to competition effects with other solubilized PAHs present at relatively high concentrations. We suggest that nonionic surfactants may improve bioremediation performance with soils that have previously undergone extensive bioremediation to enrich for a slowly desorbing profile. 相似文献
96.
Gianluca Quarta Karim Butalag Marisa D’Elia Marisa Tinelli 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2008,266(10):2343-2347
AMS (accelerator mass spectrometry) radiocarbon dated human bone samples recovered in the deserted medieval village of Quattro Macine, Lecce, in Southern Italy, were analyzed by PIXE (particle induced X-ray emission) and PIGE (particle induced gamma ray emission). The optimization of the PIXE-PIGE experimental set-up in term of beam energy and detection geometry resulted in the possibility to obtain information about major, minor and trace elements of the samples. Unexpectedly, all the analyzed samples showed a Pb concentration higher than 50 ppm. Two possible explanations of the measured high Pb concentration are discussed in the paper: the pre-mortem intake associated with the use of Pb-rich glazed pottery and the post-mortem intake from soil as the result of diagenetic processes. 相似文献
97.
Marisa Erencia Montserrat López‐Mesas Fernando Carrillo‐Navarrete 《Polymer International》2013,62(9):1316-1323
The thermosensitive properties of the hydrogel poly(N‐isopropylacrylamide) (pNIPAAm) together with the good mechanical properties of lyocell fibres make a combination of the two to be thought of as a smart textile. In the present study the optimal values of various parameters that control the grafting process of pNIPAAm onto lyocell fibres were determined considering the influence of the interaction between them. The copolymerization of pNIPAAm hydrogel onto lyocell fibres was performed in aqueous acidic medium using cerium(IV) as initiator. An experimental design was planned in order to study the effect of the interactions between some variables that affect the kinetics of the graft copolymerization: the cerium(IV) initiator concentration, the N‐isopropylacrylamide (NIPAAm) monomer concentration and the liquor fibre‐to‐bath ratio. The results show that the interaction between the concentrations of NIPAAm and the initiator significantly affects the degree of grafting (DG), the optimum values being 1250 and 12.25 mmol L?1, respectively. In contrast, the liquor ratio parameter shows no significant interaction with the other two variables studied, meaning that it acts independently but showing a proportional relationship with respect to the DG obtained. In addition, the presence of pNIPAAm in the copolymer obtained was confirmed by Fourier transform infrared spectral analysis. Moreover, the water sorption capacity, depending on the temperature, of the lyocell/pNIPAAm copolymer was studied, with an increase being observed when the DG is higher than 60% and also increasing with the temperature.© 2012 Society of Chemical Industry 相似文献
98.
Marisa N. Pedernera Claudia Sarmoria Enrique M. Valls Adriana Brandolin 《Polymer Engineering and Science》1999,39(10):2085-2095
We propose a generalized kinetic model for the peroxide initiated modification of polyethylene. It takes into account not only combination reactions but also transfer to polymer and scission. The model describes the length of the polymer chain and the concentration of vinyl groups simultaneously. Any number of vinyl groups per molecule is allowed. The resulting infinite system of mass balance equations is solved using a double moment technique. The model calculates number, weight and z-average molecular weights and the average concentration of vinyl groups as functions of time. The kinetic constants and the initiation efficiency were estimated through a nonlinear regression using experimental data. The relevance of each one of the reactions included in the mechanism was assessed. By means of the model we studied the influence of temperature and initial peroxide concentration on the modified polymer properties. It follows well the observed experimental trends and gives good estimates of both average molecular weights and average vinyl content, within experimental error. 相似文献
99.
Marisa De Sousa Duarte Matthieu Rolland Corinne Sagnard Didier Suire Frederic Flacher Olivier Delpoux Charles P. Lienemann 《化学工程与技术》2019,42(3):655-660
A 3‐MPa, 350 °C fixed‐bed reactor was designed to follow‐up gas‐liquid‐solid reactions on a millimetric size heterogeneous catalyst with Raman spectroscopy. The transparent reactor is a quartz cylinder enclosed in a Joule effect heated stainless‐steel tube. A methodology to determine how to focus the microscope for liquid and solid phase characterization is presented. The setup was validated by performing diesel hydrodesulfurization on a CoMo/alumina extrudate catalyst with a conversion very close to expected values along with the acquisition of Raman spectra of the solid catalyst showing an evolution of the catalyst phase during sulfidation. 相似文献