全文获取类型
收费全文 | 850篇 |
免费 | 32篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 5篇 |
综合类 | 4篇 |
化学工业 | 185篇 |
金属工艺 | 16篇 |
机械仪表 | 12篇 |
建筑科学 | 12篇 |
能源动力 | 119篇 |
轻工业 | 29篇 |
水利工程 | 3篇 |
石油天然气 | 2篇 |
无线电 | 82篇 |
一般工业技术 | 198篇 |
冶金工业 | 33篇 |
原子能技术 | 8篇 |
自动化技术 | 175篇 |
出版年
2023年 | 11篇 |
2022年 | 39篇 |
2021年 | 31篇 |
2020年 | 22篇 |
2019年 | 30篇 |
2018年 | 27篇 |
2017年 | 17篇 |
2016年 | 35篇 |
2015年 | 31篇 |
2014年 | 37篇 |
2013年 | 49篇 |
2012年 | 85篇 |
2011年 | 79篇 |
2010年 | 63篇 |
2009年 | 52篇 |
2008年 | 45篇 |
2007年 | 25篇 |
2006年 | 18篇 |
2005年 | 14篇 |
2004年 | 17篇 |
2003年 | 16篇 |
2002年 | 9篇 |
2001年 | 9篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 16篇 |
1997年 | 7篇 |
1996年 | 10篇 |
1995年 | 11篇 |
1994年 | 5篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 8篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1968年 | 3篇 |
1967年 | 2篇 |
排序方式: 共有883条查询结果,搜索用时 15 毫秒
21.
Paul-Mihai Boarescu Ioana Boarescu Raluca Maria Pop tefan Horia Roian Ioana Corina Bocan Vasile Rus Rzvan Olimpiu Mada Iulia Diana Popa Nicholas Neagu Adriana Elena Bulboac Anca Dana Buzoianu Sorana D. Bolboac 《International journal of molecular sciences》2022,23(3)
The present study aims to compare the oxidative stress biomarkers, pro-inflammatory cytokines, and histological changes induced by three cardiovascular risk factors, namely, hypertension, dyslipidemia, and type 1 diabetes mellitus. Hypertension was induced with 40 mg/kg body weight (b.w.) of N omega-nitro-L-arginine-methyl (L-NAME) administered orally. Dyslipidemia was induced by the administration of a diet with a high cholesterol (2%) content. Diabetes mellitus was induced by intraperitoneal administration of a single dose of streptozocin (65 mg/kg). Malondialdehyde (MDA) and total oxidative status (TOS) are increased by all three cardiovascular risk factors (up to 207%). The indirect assessment of NO synthesis (NOx) is observed to be reduced after L-NAME administration (43%), and dyslipidemia induction (16%), while type 1 diabetes mellitus is associated with the highest levels of NOx (increased 112%). Hypertension, dyslipidemia, and type 1 diabetes reduced the total antioxidative capacity (TAC) and total thiol (SH) levels (up to 57%). The values of evaluated pro-inflammatory cytokines, tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), assessed from the ascending aorta were elevated by all three cardiovascular risk factors, with the highest levels induced by type 1 diabetes mellitus (up to 259%). The histopathological examination of the ascending and descending aorta revealed reversible pro-atherogenic changes consisting of the accumulation of lipid droplets in the subendothelial connective tissue on rats with hypertension and dyslipidemia. Irreversible pro-atherogenic changes consisting of a reduction of the specific elasticity of the arteries were observed in rats with type 1 diabetes mellitus. Type 1 diabetes mellitus demonstrates an alteration of the oxidative stress parameters, the elevation of tissue levels of the pro-inflammatory cytokines and causing irreversible pro-atherogenic changes on the aortic wall. 相似文献
22.
Cristiana Tanase Ana Maria Enciu Elena Codrici Ionela Daniela Popescu Maria Dudau Ana Maria Dobri Sevinci Pop Simona Mihai Ancua-Augustina Gheorghian-Gleanu Mihail Eugen Hinescu 《International journal of molecular sciences》2022,23(2)
Glioblastoma (GBM) is one of the most aggressive tumors of the central nervous system, characterized by a wide range of inter- and intratumor heterogeneity. Accumulation of fatty acids (FA) metabolites was associated with a low survival rate in high-grade glioma patients. The diversity of brain lipids, especially polyunsaturated fatty acids (PUFAs), is greater than in all other organs and several classes of proteins, such as FA transport proteins (FATPs), and FA translocases are considered principal candidates for PUFAs transport through BBB and delivery of PUFAs to brain cells. Among these, the CD36 FA translocase promotes long-chain FA uptake as well as oxidated lipoproteins. Moreover, CD36 binds and recognizes thrombospondin-1 (TSP-1), an extracellular matrix protein that was shown to play a multifaceted role in cancer as part of the tumor microenvironment. Effects on tumor cells are mediated by TSP-1 through the interaction with CD36 as well as CD47, a member of the immunoglobulin superfamily. TSP-1/CD47 interactions have an important role in the modulation of glioma cell invasion and angiogenesis in GBM. Separately, FA, the two membrane receptors CD36, CD47, and their joint ligand TSP-1 all play a part in GBM pathogenesis. The last research has put in light their interconnection/interrelationship in order to exert a cumulative effect in the modulation of the GBM molecular network. 相似文献
23.
Kaktcham Pierre Marie Zambou Ngoufack François Foko Kouam Edith Marius Oana Ciobotaru Florentina Matei Calina Petruta Cornea 《Food Biotechnology》2013,27(4):237-256
This study aims to evaluate the antifungal activity of lactic acid bacteria (LAB) from some Cameroonian food commodities against mycotoxigenic and spoilage molds. Following LAB isolation, the antifungal activity of the isolates was assessed. The organic acids were quantified using high-performance liquid chromatography and the ability of the LAB to reduce mold biomass and aflatoxin production was evaluated. The LAB were identified and the biopreservative potential of strain LO3 was evaluated on tomato paste. Nine percent of the strains isolated showed broad antifungal activity. The activity was due to the effect of organic acids comprising lactic, acetic, 4-hydroxy-3-phenyllactic and 3-phenyllactic acids. Lactobacillus plantarum LO3 exhibiting the highest and broadest antifungal activity was selected and showed the capacity to inhibit fungal growth and aflatoxin production in vitro. Moreover, this strain and its cell-free supernatant showed the ability to prevent aflatoxigenic mold growth in tomato paste without altering its physico-chemical and organoleptic properties. 相似文献
24.
Marius Maximini Philip Engelhardt Martin Brenner Frank Beckmann Oliver Moritz 《International Journal of Hydrogen Energy》2014
Fuel cell systems based on liquid fuels are particularly suitable for auxiliary power generation due to the high energy density of the fuel and its easy storage. Together with industrial partners, Oel-Waerme-Institut is developing a 3 kWel PEM fuel cell system based on diesel steam reforming to be applied as an APU for caravans and yachts. The start-up time of a fuel cell APU is of crucial importance since a buffer battery has to supply electric power until the system is ready to take over. Therefore, the start-up time directly affects the battery capacity and consequently the system size, weight, and cost. 相似文献
25.
Cosmin Stefan Mocanu Marius Niculaua Gheorghita Zbancioc Violeta Mangalagiu Gabi Drochioiu 《International journal of molecular sciences》2022,23(5)
Our work discusses the investigation of 75 peptide-based drugs with the potential ability to break the β-sheet structures of amyloid-beta peptides from senile plaques. Hence, this study offers a unique insight into the design of neuropeptide-based drugs with β-sheet breaker potential in the amyloid-beta cascade for Alzheimer’s disease (AD). We started with five peptides (15QKLVFF20, 16KLVFF20, 17LVFF20, 16KLVF19 and 15QKLV18), to which 14 different organic acids were attached at the N-terminal. It was necessary to evaluate the physiochemical features of these sequences due to the biological correlation with our proposal. Hence, the preliminary analysis of different pharmacological features provided the necessary data to select the peptides with the best biocompatibility for administration purposes. Our approaches demonstrated that the peptides 17LVFF20, NA-17LVFF20, 16KLVF19 and NA-16KLVF19 (NA-nicotinic acid) have the ability to interfere with fibril formation and hence improve the neuro and cognitive functions. Moreover, the peptide conjugate NA-16KLVF19 possesses attractive pharmacological properties, demonstrated by in silico and in vitro studies. Tandem mass spectrometry showed no fragmentation for the spectra of 16KLVF19. Such important results suggest that under the action of protease, the peptide cleavage does not occur at all. Additionally, circular dichroism confirmed docking simulations and showed that NA-16KLVF19 may improve the β-sheet breaker mechanism, and thus the entanglement process of amyloid-beta peptides can be more effective. 相似文献
26.
S.V. Subhashini R. Sumathi I. Pop 《International Journal of Heat and Mass Transfer》2012,55(9-10):2524-2530
The development of double-diffusive convection near stagnation point region over a stretching vertical surface with constant wall temperature has been investigated. The external flow and the stretching velocities are assumed to vary with where x is the distance from the slot where the stretching surface is issued. Using the local similarity method, it has been shown that a set of suitable similarity transformations reduces the non-linear coupled partial differential equations governing the flow, thermal and concentration fields into a set of non-linear coupled ordinary differential equations. The non-linear self-similar equations along with the boundary conditions form a two point boundary value problem and are solved using Shooting method, by converting into an initial value problem. In this method, the system of equations is converted into the set of first order system which is solved by fourth-order Runge–Kutta method. Flows with both assisting and opposing buoyancy forces are considered in the present investigation. The study reveals that the dual solutions of velocity, temperature and concentration exist for certain values of suction/injection and buoyancy parameters. Prandtl and Schmidt numbers strongly affect the thermal and concentration boundary layer thicknesses, respectively. The effects of various parameters on the velocity, temperature and concentration profiles are also presented here. 相似文献
27.
Hakan F. Oztop Moghtada Mobedi Eiyad Abu-Nada Ioan Pop 《International Journal of Heat and Mass Transfer》2012,55(19-20):5076-5086
Heatline visualization technique is used to understand heat transport path in an inclined non-uniformly heated enclosure filled with water based CuO nanofluid. The cavity has square cross-section and it is non-uniformly heated from a wall and cooled from opposite wall while other walls are adiabatic. The governing equations which are continuity, momentum and energy equations are solved using finite volume method. The dimensionless heatfunction for nanofluid heat flow is defined and solved to determine heatline patterns. Calculations were performed for Rayleigh numbers of 103, 104 and 105, inclination angle of 0°, 30°, 60° and 90°, and nanoparticle fraction of 0, 0.02, 0.04, 0.06, 0.08 and 0.1. It is observed that heat transfer in the cavity increases by adding nanoparticles. The rate of increase is greater for the enclosures with low Rayleigh number. Visualization of heatline is successfully applied to nanoparticle convective flows. Based on the heatline patterns, three heat transfer regions are observed and discussed in details. 相似文献
28.
Khalil Khanafer Abdalla Al-Amiri Ioan Pop 《International Journal of Heat and Mass Transfer》2008,51(7-8):1613-1627
The current study centers around a numerical investigation of natural convection heat transfer within a two-dimensional, horizontal annulus that is partially filled with a fluid-saturated porous medium. In addition, the porous sleeve is considered to be press fitted to the inner surface of the outer cylinder. Both cylinders are maintained at constant and uniform temperatures with the inner cylinder being subjected to a relatively higher temperature than the outer one. Moreover, the Forchheimer and Brinkman effects are taken into consideration when simulating the fluid motion inside the porous sleeve. Furthermore, the local thermal equilibrium condition is assumed to be applicable for the current investigation. The working fluid is air while copper is used to represent the solid phase. The porosity is considered to be uniform and constant with ε = 0.9. The main objective of this study is to examine the effect of the porous sleeve on the buoyancy induced flow motion under steady-state condition. Such an effect is studied using the following dimensionless parameters: Pr = 0.05–50, Ra = 102–106 and Da = 10?4–10?6. Also, the study highlights the effect of the dimensionless porous sleeve thickness (b) and thermal conductivity ratio (ks/kf) in the range between 1.1–1.9 and 1–150, respectively. 相似文献
29.
We consider a simply supported plate with constant thickness, defined on an unknown multiply connected domain. We optimize its shape according to some given performance functional. Our method is of fixed domain type, easy to be implemented, based on a fictitious domain approach and the control variational method. The algorithm that we introduce is of gradient type and performs simultaneous topological and boundary variations. Numerical experiments are also included and show its efficiency. 相似文献
30.
There are several objectives in the design phase of gears: Besides a sufficient load capacity and a high efficiency of the gearbox, the acoustic behavior has to be taken into account. For a single-stage gearbox, several research projects have been carried out regarding the improvement of the noise behavior. Because of the mutual interactions between the gear meshes at a multi-stage gearbox, the knowledge at single-stage gearboxes cannot be transferred without restrictions. In this report, experimental investigations are carried out on a two-stage test gearbox. The experimental tests are analyzed by means of the stiffness of the intermediate shaft and the number of teeth of the two gear stages. The noise generation process will be investigated by the measured signals along the machine acoustic noise generation process. First, the excitation behavior of the gear mesh is analyzed by the detected rotational acceleration using angular rotation measurement systems. Subsequently, the transfer path between the gear meshes is determined to evaluate the mutual interactions between source and receiver. Based on the results, a guideline will be provided which stage has to be focused during the design phase. 相似文献