The effect of structural features on mechanical properties of loose optical fiber poly(butylene terephthalate) tubes

Results of a study on the modifying mechanical properties of loose optical‐fiber poly(butylene terephthalate) (PBT) tubes, produced during the standard industrial extrusion process, show that heat treatment make the structure of their material to change. The study comprised measurements of mechanical strengths properties of the tubes (tensile strength, compression strength, kinking) and determination of tube material structure [by differential thermal analysis (DTA), wide angle X‐ray scattering analysis (WAXD), and scanning electron microscopy (SEM)]. Results of the study allowed observation that the annealing at 70°C for 34 h of the tubes caused the crystalline α phase to increase in the tube material from ～28.5% to ～31.5% and the structure of the existing crystallites to become more perfect. This made the values of certain mechanical properties of the tubes to increase even by as much as 30%. The tubes following such thermal treatment could be used in cables exposed to heavy‐duty operation in arduous environments, where a larger margin from the standpoint of mechanical properties is required. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2130–2134, 2002     

Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response

Cyclin-dependent kinases (CDKs) are pivotal mediators and effectors of the DNA damage response (DDR) that regulate both the pathway components and proteins involved in repair processes. Synthetic lethality (SL) describes a situation in which two genes are linked in such a way that the lack of functioning of just one maintains cell viability, while depletion of both triggers cell death. Synthetic lethal interactions involving CDKs are now emerging, and this can be used to selectively target tumor cells with DNA repair defects. In this review, SL interactions of CDKs with protooncogene products MYC, poly (ADP-ribose) polymerase (PARP-1), and cellular tumor antigen p53 (TP53) are discussed. The individual roles of each of the SL partners in DDR are described.     

Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression

The accumulation of mutations in cancer driver genes, such as tumor suppressors or proto-oncogenes, affects cellular homeostasis. Disturbances in the mechanism controlling proliferation cause significant augmentation of cell growth and division due to the loss of sensitivity to the regulatory signals. Nowadays, an increasing number of cases of liver cancer are observed worldwide. Data provided by the International Cancer Genome Consortium (ICGC) have indicated many alterations within gene sequences, whose roles in tumor development are not well understood. A comprehensive analysis of liver cancer (virus-associated hepatocellular carcinoma) samples has identified new and rare mutations in B-Raf proto-oncogene (BRAF) in Japanese HCC patients, as well as BRAF V600E mutations in French HCC patients. However, their function in liver cancer has never been investigated. Here, using functional analysis and next generation sequencing, we demonstrate the tumorigenic effect of BRAF V600E on hepatocytes (THLE-2 cell line). Moreover, we identified genes such as BMP6, CXCL11, IL1B, TBX21, RSAD2, MMP10, and SERPIND1, which are possibly regulated by the BRAF V600E-mediated, mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) signaling pathway. Through several functional assays, we demonstrate that BRAF L537M, D594A, and E648G mutations alone are not pathogenic in liver cancer. The investigation of genome mutations and the determination of their impact on cellular processes and functions is crucial to unraveling the molecular mechanisms of liver cancer development.     

New lake district in Europe: origin and hydrochemical characteristics

This article presents a new lake district in Southern Poland created as a result of human activity in the Upper Silesian region. The area has been named the Upper Silesian Anthropogenic Lake District. The lake density of the Lake District as delineated by the authors (with an area of 6766 km²) is 2.74%. It includes 4773 water bodies of various origins – reservoirs retained by dams, flooded mineral workings, water bodies formed in subsidence basins and hollows, levee ponds, residual water bodies following river regulation and other water bodies. These are located in urban‐industrial, rural‐agricultural or quasi‐natural areas. The hydrochemical diversity of water bodies is conditioned by their origin, location in the catchment and function. Studies have shown the widespread occurrence of eutrophication processes in limnic waters within the Lake District. The diverse origin and hydrochemical properties of water bodies within the Upper Silesian Anthropogenic Lake District make it special among other anthropogenic lake districts.     

Evolutionary Algorithm Integrating Stress Heuristics for Truss Optimization

The optimal truss design using problem-oriented evolutionary algorithm is presented in the paper. The minimum weight structures subjected to stress and displacement constraints are searched. The discrete design variables are areas of members, selected from catalogues of available sections. The integration of the problem specific knowledge into the optimization procedure is proposed. The heuristic rules based on the concept of fully stressed design are introduced through special genetic operators, which use the information concerning the stress distribution of structural members. Moreover, approximated solutions obtained by deterministic, sequential discrete optimization methods are inserted into the initial population. The obtained hybrid evolutionary algorithm is specialized for truss design. Benchmark problems are calculated in numerical examples. The knowledge about the problem integrated into the evolutionary algorithm can enhance considerably the effectiveness of the approach and improve significantly the convergence rate and the quality of the results. The advantages and drawbacks of the proposed method are discussed.     

Online determination of transient thermal stresses in critical steam turbine components using a two-step algorithm

The article presents a novel algorithm for robust calculation of thermal stresses in steam turbine components during transient operating conditions. Stress calculations are performed in 2 steps: in the first step an unsteady radial temperature distribution in the component model is computed, and based on this thermal stresses at critical locations are determined in the second step. The radial temperature distribution is obtained by solving the Fourier-Kirchhoff equation for a cylinder or sphere by means of a finite difference method. The thermal stresses are computed using the Duhamel integral and Green functions evaluated with a constant heat transfer coe?cient and used with an equivalent steam temperature obtained from the surface heat flux.     

Ventilation system with spiral recuperator

A new kind of longitudinal flow spiral recuperator for the heat recovery in ventilation systems of buildings was studied experimentally and analytically.The aim of this work is to analyze the possibility of using air handling units with new type of spiral recuperator in order to recover heat in ventilation systems of buildings. For the reason that the air flows are parallel to the symmetry axis of the longitudinal flow spiral recuperator, in this unit pressure drops are smaller than in commonly known spiral exchangers. Because of the counter flow, a greater value of thermal effectiveness ? is reached for the same value of the number of transfer units in comparison to cross-flow recuperators.The exploitation of the new type of spiral recuperator in winter periods brings significant savings. The results obtained from computations are very encouraging for a widespread use of these devices.