Identification of new epidemiological molecular markers by comparative proteomics of serogroup A meningococcal isolates from three pandemic waves

We previously described the first reference map for the proteome of one strain of serogroup A Neisseria meningitidis (MenA), a major cause of epidemic meningitis in humans. As a preliminary finding, in that work we noted that 2‐DE protein maps of closely related MenA isolates from different epidemics spreads could be easily compared to detect minor differences and that 2‐DE phenotypes attributable to the well‐known epidemiological marker tbpB agreed with the genoclouds model of MenA epidemiological variation during pandemic waves. We explored here the possibility that an extended comparative study of 2‐DE maps of isolates representative of the nine genoclouds described by Achtman and collaborators could be used to discriminate between strains otherwise undistinguishable. We showed the example of 14 proteins with different 2‐DE spot patterns in different genoclouds that could be considered as putative tracers for alike‐strains discrimination. We introduce the novel concept that comparative proteomics can be useful in identifying new epidemiological markers for N. meningitidis.     

MnS doped mesoporous silica catalysts for the generation of novel carbon nanocages

Novel MnS impregnated mesoporous silica systems have been originated for the generation of carbon nanocages. The procedure involves a simple catalytic vapour deposition (CVD) method. This is the first time that a transition metal sulfide has been used for the synthesis of carbon nanostructures.     

Pygmalion revisited: New evidence for student expectancy effects in the classroom.

We conducted a field experiment to test the idea that students' expectations regarding their teacher's competence would influence their classroom behavior and academic achievement. At the end of a 3-week teaching unit, students in two high school classes who had been given an initial positive expectancy about their teacher's ability and motivation engaged in more appropriate and less inappropriate nonverbal behavior and received significantly higher final grades on the unit than did their peers in two no-expectation control classes. We speculate about both the direct (student-mediated) and indirect (teacher-mediated) processes by which students' expectations came to affect their academic outcomes. We also discuss the importance of group-level expectancies and some ethical issues in student expectancy research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cold fusion experiments using Maxwellian plasmas and sub-atmospheric deuterium gas

Experiments are being performed to initiate the cold fusion process in Maxwellian plasmas and sub-atmospheric deuterium gas. Thus far, apparent neutron counts have been observed using a BF₃ probe and Ludlum model 2200 digital counter, and a broad 8.1 MeV peak has been observed using a 3-inch sodium iodide crystal and a Nucleus PCA II multichannel analyzer. The results appear to be dependent upon the temperature of the palladium sample, deuterium pressure, and the type of palladium sample used. The results are interesting but not sufficient for any conclusions at this point.     

Rethinking downstream regulation: California's opportunity to engage households in reducing greenhouse gases

With the passage of the Global Warming Solutions Act of 2006 (AB32), California has begun an ambitious journey to reduce in-state GHG emissions to 1990 levels by 2020. Under the direction of executive order S-20-06, a mandated Market Advisory Committee (MAC) charged with studying market-based mechanisms to reduce GHG emissions, including cap and trade systems, has recommended taking an “upstream” approach to GHG emissions regulation, arguing that upstream regulation will reduce administrative costs because there are fewer agents. In this paper, we argue that, the total costs to society of a GHG cap and trade scheme can be minimized though downstream regulation, rather than the widely proposed upstream approach. We propose a household carbon trading system with four major components: a state allocation to households, household-to-household trading, households to utility company credit transfers, and utility companies to government credit transfers. The proposed system can also be considered more equitable than carbon taxes and upstream cap and trade systems to control GHG emissions from residential energy use and is consistent with AB32.     

Sensitivity of tag-recovery mortality estimates to inaccuracies in tag shedding,handling mortality,and tag reporting

We used Monte Carlo simulations to evaluate the sensitivity of tag-recovery mortality estimates to inaccuracies in tag shedding, handling mortality, and tag reporting. The data-generating model used in the simulations assumed that tagging was conducted annually for 4 years with tag recoveries occurring over a 4-year period. Several different combinations of instantaneous fishing (F) and natural (M) mortality were evaluated in the simulations. The data-generating model additionally assumed that immediate-shedding and handling-mortality rates equaled 2.5% and 0%, respectively, and that chronic shedding was a sigmoidal function of months since tagging. Two spatial patterns of reporting rates were considered—one where reporting was a function of distance from the tagging site and one where reporting was a random generation across the study area. Maximum likelihood estimates of F and M were calculated from the recovery of tags from the data-generating model under different assumed rates of tag shedding, handling mortality, and tag reporting. We found that assumptions about reporting rates resulted in the most variability in mortality estimates regardless of which combination of F and M was evaluated, with assumptions about chronic shedding also contributing substantially to overall variability in mortality estimates for most mortality combinations. Assumptions about immediate tag shedding and handling mortality had relatively minor effects on mortality estimates compared to reporting rate. When planning a tag-recovery study, care should be taken to ensure that chronic shedding and tag-reporting rates are accurately measured, as inaccurate measurements in these factors can result in significant errors in mortality estimates.     

Ductility and Cracking Behavior of Prestressed Concrete Beams Strengthened with Prestressed CFRP Sheets

This paper investigates the flexure of prestressed concrete beams strengthened with prestressed carbon fiber-reinforced polymer (CFRP) sheets, focusing on ductility and cracking behavior. Structural ductility of a beam strengthened with CFRP sheets is critical, considering the abrupt and brittle failure of CFRP sheets themselves. Cracking may also affect serviceability of a strengthened beam, and may be especially important for durability. Midscale prestressed concrete beams (L = 3.6?m) are constructed and a significant loss of prestress is simulated by reducing the reinforcement ratio to observe the strengthening effects. A nonlinear iterative analytical model, including tension of concrete, is developed and a nonlinear finite-element analysis is conducted to predict the flexural behavior of tested beams. The prestressed CFRP sheets result in less localized damage in the strengthened beam and the level of the prestress in the sheets significantly contributes to the ductility and cracking behavior of the strengthened beams. Consequently, the recommended level of prestress to the CFRP sheets is 20% of the ultimate design strain with adequate anchorages.