Open Pluggable Edge Services: An Architecture for Networked Content Services

The IETF's open pluggable edge services (OPES) working group focuses on rule-based, in-line transformation services of data flows between two Internet endpoints, such as Web servers and Web clients. The group has developed an architectural framework to authorize, invoke, and trace such application-level services. The framework follows a one-party consent model, which requires that at least one of the application-layer endpoints explicitly authorize each service. OPES services must also be reversible by request of the application endpoints     

Towards stable diagnostic setups in clinical proteomics: Absolute quantitation of peptide biomarkers using MALDI‐TOF‐MS

In routine clinical diagnostics, peptide biomarkers are most commonly quantified using immunological techniques but these methods often lack sensitivity and/or specificity. Hence, quantitative mass spectrometry detection is desirable as an alternative diagnostic tool. To date, quantitative mass spectrometry is mostly based on ESI‐MS coupled to LC, requiring highly sophisticated instrumentation and knowledge and is time consuming and expensive. In contrast, MALDI‐TOF‐MS is a very simple, sensitive and rapid method for the detection of peptide biomarkers. However, the infeasibility of absolute quantification has been a tremendous handicap to the use of MS in stable clinical diagnostics. Here, we describe the development of a technical platform based on ClinProt particles and heavy‐isotope internal peptide standards for the fast and reliable preparation of samples. This combines the advantages of MALDI‐TOF as a read‐out system with absolute quantitation of peptide biomarkers. As a proof‐of‐concept, this platform was successfully employed for the absolute determination of the concentration of the highly abundant serum peptide des‐Ala‐Fibrinopeptide A in 45 serum samples from healthy donors. Such technology essentially contributes to the development of a stable MALDI‐TOF‐MS‐based clinical assay.     

Neue Entwicklungen bei Überströmstrecken von Dämmen

The experiments conducted to date at the TU Vienna’s Hydraulic Laboratory, some of which involved classic construction methods for revetments and alternative constructions, should be used as a foundation, contributing to their optimization and continuing technical/commercial evolution. The construction solutions already explored will need to be developed further so as to accommodate steeper bank angles and specific hydraulic strains; this will allow them to be serve as a broad basis for planning engineers and help to ensure the safety of overflow sections.     

Evaluating the limitations of and alternatives in beaconing

In position-based routing protocols, each node periodically transmits a short hello message (called beacon) to announce its presence and position. Receiving nodes list all known neighbor nodes with their position in the neighbor table and remove entries after they have failed to receive a beacon for a certain time from the corresponding node. In highly dynamic networks, the information stored in the neighbor table is often outdated and does no longer reflect the actual topology of the network causing retransmissions and rerouting that consume bandwidth and increase latency. An analysis on the possible impact of beacons due outdated and inaccurate neighbor tables is needed. We quantify by analytical and simulation means the possible performance loss and explore the limitations of position-based routing protocols which use beaconing. In highly mobile ad-hoc networks, the delay can increase by a factor of 20. The neighbor table inaccuracy is the main source of packet loss in uncongested networks. We propose and evaluate several concrete mechanisms to improve the accuracy of neighborhood information, e.g., by dynamic adaptation of the timer values when beacons are broadcasted, and show their effectiveness by extensive simulation.     

Modelling and validation of granulation with heterogeneous binder dispersion and chemical reaction

In this paper a multidimensional model for binder granulation is presented. The particles undergo different transformations such as coalescence, compaction, and breakage. Further chemical reaction in the granules is taken into account in order to incorporate binder solidification which is observed to be a significant transformation in many industrial applications. The equations of the model framework are solved numerically with a direct simulation Monte Carlo (DSMC) algorithm. In addition to the comparison between experiment and simulation, the model framework also enables the study of critical parameters in binder granulation such as reaction rate (solidification of binder) and size of the added binder droplets, which demonstrates its promising potential.     

Coordinate transformations in object recognition.

A basic problem of visual perception is how human beings recognize objects after spatial transformations. Three central classes of findings have to be accounted for: (a) Recognition performance varies systematically with orientation, size, and position; (b) recognition latencies are sequentially additive, suggesting analogue transformation processes; and (c) orientation and size congruency effects indicate that recognition involves the adjustment of a reference frame. All 3 classes of findings can be explained by a transformational framework of recognition: Recognition is achieved by an analogue transformation of a perceptual coordinate system that aligns memory and input representations. Coordinate transformations can be implemented neurocomputationally by gain (amplitude) modulation and may be regarded as a general processing principle of the visual cortex. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

气泡城市

Spacebuster是个动态的充气结构，它是便携式、可拓展的场馆。设计旨在将各种公共空间转变为可以进行社交集会的场所。事实上，Spacebuster是Raumlabo健筑设计事务所对上一个项目Kuechenmonumenl的迭代创新，它使得曼哈顿和布鲁克林的春天大放异彩，承办了很多各种社交和公众活动。