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排序方式: 共有2521条查询结果,搜索用时 15 毫秒
11.
Cássia A. Glasser Marta M. D. C. Vila Júlio C. Pereira Marco V. Chaud José M. Oliveira Júnior Matthieu Tubino 《Drug development and industrial pharmacy》2016,42(12):1990-2000
The aqueous-core enclosed in lipid nanoballoons integrating multiple emulsions of the type water-in-oil-in-water mimic, at least in theory, the environment within viable cells, thus being suitable for housing hydrophilic protein entities such as bioactive proteins, peptides and bacteriophage particles. This study reports a complete physicochemical characterization of optimized biomimetic aqueous-core lipid nanoballoons housing hydrophilic (BSA) protein entities, evolved from a statistical 23×31 factorial design study (three variables at two levels and one variable at three levels) that was the subject of the first paper of a series of three, aiming at complete stabilization of the three-dimensional structure of protein entities attempted via housing the said molecular entities within biomimetic aqueous-core lipid nanoballoons integrating a multiple (W/O/W) emulsion. The statistical factorial design followed led to the production of an optimum W/O/W multiple emulsion possessing quite homogeneous particles with an average hydrodynamic size of (186.2?±?2.6) nm and average Zeta potential of (?36.5?±?0.9) mV, and exhibiting a polydispersity index of 0.206?±?0.014. Additionally, the results obtained for the diffusion coefficient of the lipid nanoballoons integrating the optimized W/O/W multiple emulsion were comparable and of the same order of magnitude (10?12 m2 s?1) as those published by other authors since, typically, diffusion coefficients for molecules range from 10?10 to 10?7 m2 s?1, but diffusion coefficients for nanoparticles are typically of the order of magnitude of 10?12 m2 s?1. 相似文献
12.
Marta Alberti Joaquim Ciurana Ciro A. Rodríguez Tugrul Özel 《Journal of Intelligent Manufacturing》2011,22(2):263-277
Economic globalization, together with heightened market competition and increasingly short product life cycles are motivating
companies to use advanced manufacturing technologies. Use of high speed machining is increasingly widespread; however, as
the technology is relatively new, it lacks a deep-rooted knowledge base which would facilitate implementation. One of the
most frequent problems facing companies wishing to adopt this technology is selecting the most appropriate machine tool for
the product in question and own enterprise characteristics. This paper presents a decision support system for high speed milling
machine tool selection based on machine characteristics and performance tests. Profile machining tests are designed and conducted
in participating machining centers. The decision support system is based on product dimension accuracy, process parameters
such as feed rate and interpolation scheme used by CNC and machine characteristics such as machine accuracy and cost. Experimental
data for process error and cycle operation time are obtained from profile machining tests with different geometrical feature
zones that are often used in manufacturing of discrete parts or die/moulds. All those input parameters have direct impact
on productivity and manufacturing cost. Artificial neural network models are utilized for decision support system with reasonable
prediction capability. 相似文献
13.
José Luis Crespo Marta Zorrilla Pilar Bernardos Eduardo Mora 《The Visual computer》2009,25(4):309-323
The objective of this paper is to present an overall approach to forecasting the future position of the moving objects of
an image sequence after processing the images previous to it. The proposed method makes use of classical techniques such as
optical flow to extract objects’ trajectories and velocities, and autoregressive algorithms to build the predictive model.
Our method can be used in a variety of applications, where videos with stationary cameras are used, moving objects are not
deformed and change their position with time. One of these applications is traffic control, which is used in this paper as
a case study with different meteorological conditions to compare with.
相似文献
Marta Zorrilla (Corresponding author)Email: |
14.
In this paper we introduce a method to compute non-dominated bicriteria shortest pairs, each including two disjoint simple paths. The method is based on an algorithm for ranking pairs of disjoint simple paths by non-decreasing order of cost, that is an adaptation of a path ranking algorithm applied to a network obtained from the original one after a suitable modification of the topology. Each path in this new network corresponds to a pair of paths in the former one. Computational results are presented and analysed for randomly generated networks. 相似文献
15.
Marta Gonzlez Llúcia Masip Antoni Granollers Marta Oliva 《Advances in Engineering Software》2009,40(12):1271-1278
In usability context of interactive systems the heuristic evaluation method is widespread. In most applications the results tend to be qualitative, describing such aspects that require some improvement for the benefit of usability. However, these qualitative results do not allow us to determine how usable it is or how it becomes an interactive system. Hence the need for quantitative results may also be very necessary in order to determine the effort that would be needed to get a sufficiently usable system.This article describes, following the idea of the UsabAIPO Project, a new experiment to obtain quantitative results after a heuristic evaluation. This new experimentation has required some variation on the original idea, working with a set of different heuristic categories, while considering the use of the score depending on severity and frequency parameters. 相似文献
16.
Arce-Urriza Marta Cebollada Javier Tarira María Fernanda 《Information Systems and E-Business Management》2017,15(1):69-87
Information Systems and e-Business Management - This study evaluates the differential effect of price promotions on brand choice across the offline and online channels of a grocery retailer. We use... 相似文献
17.
John J. A. Barry Marta M. C. G. Silva Sarah H. Cartmell Robert E. Guldberg Colin A. Scotchford Steven M. Howdle 《Journal of Materials Science》2006,41(13):4197-4204
Porous scaffold structures are used in tissue engineering to provide structural guidance for regenerating tissues. The use
of carbon dioxide (CO2) to create such scaffolds has received some attention in the past but many researchers believe that although CO2 processing of polymers can lead to porous scaffolds there is limited interconnectivity between the pores. In this study,
highly porous (greater than 85%) and well interconnected scaffolds were obtained in which the size, distribution and number
of pores could be controlled. This control was achieved by altering the rate of venting from polymer discs saturated with
CO2 under modest temperature and pressure. The polymer used is a blend of poly (ethyl methacrylate) and tetrahydrofurfuryl methacrylate
(PEMA/THFMA). This polymer system has shown promise for potential applications in cartilage repair. 相似文献
18.
The aim of this work is to provide a high performance air quality simulation using the sulphur transport Eulerian model 2 (STEM-II) program. First of all we optimize the sequential program with the aim of increasing data locality. Then, the optimized program is parallelized using OpenMP shared-memory directives. Experimental results on a 32-processor SGI Origin 2000 show that the parallel program achieves important reductions in the execution times. 相似文献
19.
Pettarin Valeria Frontini Patricia Eliçabe Guillermo Rink Marta Pavan Andrea 《Mechanics of Time-Dependent Materials》2004,8(3):269-288
This paper deals with the influence of the testing equipment on impact load measurements. A previously developed method of analysis and processing of the experimental data based on a refined analogical model of the impact event and inverse problem techniques is used. This method makes it possible to obtain the mechanical response of the material, notwithstanding the disturbance of the dynamic effects associated to the test. Results from tests carried out both on falling weight and swing pendulum instrumented testing machines are compared. It is shown that this method can give an accurate estimation of the actual bending force in impact testing independent of the testing equipment. 相似文献
20.
Giulia Cancian Gianluca Tozzi Amirul Ashraf Bin Hussain Arianna De Mori Marta Roldo 《Journal of materials science. Materials in medicine》2016,27(8):126
Age related bone diseases such as osteoporosis are considered among the main causes of reduced bone mechanical stability and bone fractures. In order to restore both biological and mechanical function of diseased/fractured bones, novel bioactive scaffolds that mimic the bone structure are constantly under development in tissue engineering applications. Among the possible candidates, chitosan-based thermosensitive hydrogel scaffolds represent ideal systems due to their biocompatibility, biodegradability, enhanced antibacterial properties, promotion of osteoblast formation and ease of injection, which makes them suitable for less invasive surgical procedures. As a main drawback, these chitosan systems present poor mechanical performance that could not support load-bearing applications. In order to produce more mechanically-competent biomaterials, the combined addition of hydroxyapatite and carbon nanotubes (CNTs) is proposed in this study. Specifically, the aim of this work is to develop thermosensitive chitosan hydrogels containing stabilised single-walled and multi-walled CNTs, where their effect on the mechanical/physiochemical properties, calcium deposition patterns and ability to provide a platform for the controlled release of protein drugs was investigated. It was found that the addition of CNTs had a significant effect on the sol–gel transition time and significantly increased the resistance to compression for the hydrogels. Moreover, in vitro calcification studies revealed that CNTs played a major role in the spatial arrangements of newly formed calcium deposits in the composite materials studied, suggesting that they may have a role in the way the repair of fragile and/or fractured bones occurs in vivo. 相似文献