全文获取类型
收费全文 | 2331篇 |
免费 | 111篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 15篇 |
综合类 | 6篇 |
化学工业 | 737篇 |
金属工艺 | 65篇 |
机械仪表 | 43篇 |
建筑科学 | 167篇 |
矿业工程 | 7篇 |
能源动力 | 86篇 |
轻工业 | 369篇 |
水利工程 | 7篇 |
石油天然气 | 7篇 |
无线电 | 109篇 |
一般工业技术 | 412篇 |
冶金工业 | 94篇 |
原子能技术 | 22篇 |
自动化技术 | 298篇 |
出版年
2024年 | 7篇 |
2023年 | 36篇 |
2022年 | 126篇 |
2021年 | 144篇 |
2020年 | 64篇 |
2019年 | 57篇 |
2018年 | 55篇 |
2017年 | 82篇 |
2016年 | 61篇 |
2015年 | 72篇 |
2014年 | 75篇 |
2013年 | 140篇 |
2012年 | 113篇 |
2011年 | 169篇 |
2010年 | 116篇 |
2009年 | 118篇 |
2008年 | 134篇 |
2007年 | 108篇 |
2006年 | 86篇 |
2005年 | 73篇 |
2004年 | 68篇 |
2003年 | 55篇 |
2002年 | 58篇 |
2001年 | 29篇 |
2000年 | 24篇 |
1999年 | 23篇 |
1998年 | 40篇 |
1997年 | 31篇 |
1996年 | 25篇 |
1995年 | 18篇 |
1994年 | 16篇 |
1993年 | 16篇 |
1992年 | 13篇 |
1991年 | 12篇 |
1990年 | 14篇 |
1989年 | 17篇 |
1988年 | 15篇 |
1987年 | 17篇 |
1986年 | 15篇 |
1985年 | 13篇 |
1984年 | 10篇 |
1983年 | 12篇 |
1982年 | 7篇 |
1981年 | 7篇 |
1980年 | 8篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1976年 | 7篇 |
1974年 | 7篇 |
1972年 | 4篇 |
排序方式: 共有2444条查询结果,搜索用时 10 毫秒
71.
Incompatible land use is a major contributor to ecosystem degradation, and is often exacerbated by climate change impacts. We investigate Lake Basotu, Tanzania as a case study where natural lake variability has been affected by agricultural land use. Comparisons between a satellite-derived history of lake surface area, local precipitation records, and corresponding anthropogenic activity show the impacts of agricultural and historical practices. We argue that insufficient consideration to the wider ecological impacts of large agricultural projects has lasting implications. This is particularly true in semi-arid environments where food production demands need to be continuously met. In the future, major conservation strategies should be investigated to maintain the environmental integrity and sustainability of freshwater resources. 相似文献
72.
X-ray diffraction technique, combined with digital image processing was used to compare the crystallinity of native starch from a number of potato varieties, differing in the degree of phosphorylation. The crystallinity was found to decrease linearily with an increased degree of phosphorylation. Based on earlier observations of the gelatinization enthalpies, it was assumed that the C-6 phosphates, which have an orientation out of the α-helices disturb the crystallization of the amylopectin during the starch synthesis. The C-3 phosphates, which are located in the interior parts of the α-helices, are not believed to interfere with the crystal structure. 相似文献
73.
Parastoo Memarian Elham Pishavar Federica Zanotti Martina Trentini Francesca Camponogara Elisa Soliani Paolo Gargiulo Maurizio Isola Barbara Zavan 《International journal of molecular sciences》2022,23(3)
The successful clinical application of bone tissue engineering requires customized implants based on the receiver’s bone anatomy and defect characteristics. Three-dimensional (3D) printing in small animal orthopedics has recently emerged as a valuable approach in fabricating individualized implants for receiver-specific needs. In veterinary medicine, because of the wide range of dimensions and anatomical variances, receiver-specific diagnosis and therapy are even more critical. The ability to generate 3D anatomical models and customize orthopedic instruments, implants, and scaffolds are advantages of 3D printing in small animal orthopedics. Furthermore, this technology provides veterinary medicine with a powerful tool that improves performance, precision, and cost-effectiveness. Nonetheless, the individualized 3D-printed implants have benefited several complex orthopedic procedures in small animals, including joint replacement surgeries, critical size bone defects, tibial tuberosity advancement, patellar groove replacement, limb-sparing surgeries, and other complex orthopedic procedures. The main purpose of this review is to discuss the application of 3D printing in small animal orthopedics based on already published papers as well as the techniques and materials used to fabricate 3D-printed objects. Finally, the advantages, current limitations, and future directions of 3D printing in small animal orthopedics have been addressed. 相似文献
74.
75.
76.
Jonathan Mandel Martina Casari Maria Stepanyan Alexey Martyanov Carsten Deppermann 《International journal of molecular sciences》2022,23(7)
There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the innate immune system such as neutrophils, monocytes and macrophages. In this review, we will focus on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. We take a closer look at the contributions of major platelet receptors GPIb, αIIbβ3, TLT-1, CLEC-2 and Toll-like receptors (TLRs) as well as secretions from platelet granules on platelet–neutrophil aggregate and neutrophil extracellular trap (NET) formation in atherosclerosis, transfusion-related acute lung injury (TRALI) and COVID-19. Further, we will address platelet–monocyte and macrophage interactions during cancer metastasis, infection, sepsis and platelet clearance. 相似文献
77.
Martina Magni Chiara Paolizzi Chiara Monfrini Cristina Vella Paolo Corradini Cristiana Carniti 《International journal of molecular sciences》2022,23(7)
Mature T-cell lymphomas (MTCLs) represent a heterogeneous group of aggressive non-Hodgkin lymphomas comprising different entities. Anthracycline-based regimens are considered the standard of care in the front-line treatment. However, responses to these approaches have been neither adequate nor durable, and new treatment strategies are urgently needed to improve survival. Genomic instability is a common feature of cancer cells and can be caused by aberrations in the DNA damage response (DDR) and DNA repair mechanisms. Consistently, molecules involved in DDR are being targeted to successfully sensitize cancer cells to chemotherapy. Recent studies showed that some hematological malignancies display constitutive DNA damage and intrinsic DDR activation, but these features have not been investigated yet in MTCLs. In this study, we employed a panel of malignant T cell lines, and we report for the first time the characterization of intrinsic DNA damage and basal DDR activation in preclinical models in T-cell lymphoma. Moreover, we report the efficacy of targeting the apical kinase ATM using the inhibitor AZD0156, in combination with standard chemotherapy to promote apoptotic cell death. These findings suggest that DDR is an attractive pathway to be pharmacologically targeted when developing novel therapies and improving MTCL patients’ outcomes. 相似文献
78.
Interaction of polymers and other organic admixtures on Portland cement hydration is reviewed. This has been compiled in a systematic way. First hydration of Portland cement is described in short. Later, interaction with 4 important components of Portland cement is discussed. Finally interphase effects in polymer modified hydraulic cement are discussed. It is concluded that polymers and organic admixtures interact with the components of Portland cement when they come in contact with water. This interaction is due to ionic binding, causing cross-links which inhibit the film formation property of polymers and influence considerably the crystallisation process during the hardening of concrete. Some low molecular weight organic substances also have a considerable influence on Portland cement during its reaction with water. 相似文献
79.
Achieving economic competitiveness as compared to LWRs and other Generation IV (Gen-IV) reactors is one of the major requirements to attract large-scale investment in commercial sodium cooled fast reactor (SFR) power plants. Advances in R&D for advanced SFR fuel and structural materials provide key long-term opportunities to improve SFR economics. In addition, other new opportunities are emerging to further improve SFR economics. This paper provides an overview on potential ideas from the perspective of thermal hydraulics to improve SFR economics. These include: (1) a new hybrid loop-pool reactor design to further optimize economics, safety, and reliability of SFRs with more flexibility, (2) a multiple-reheat and intercooling helium Brayton cycle to improve plant thermal efficiency and to reduce safety related overnight and operation costs, and (3) modern multi-physics thermal analysis methods to reduce analysis uncertainties and associated requirements for over-conservatism in reactor design. This paper reviews advances in all three areas and their potential beneficial impacts on SFR economics. 相似文献
80.
Martina Casarin Tiago Moderno Fortunato Saima Imran Martina Todesco Deborah Sandrin Giulia Borile Ilaria Toniolo Massimo Marchesan Gino Gerosa Andrea Bagno Filippo Romanato Emanuele Luigi Carniel Alessandro Morlacco Fabrizio Dal Moro 《International journal of molecular sciences》2022,23(5)
Bladder cancer (BC) is among the most common malignancies in the world and a relevant cause of cancer mortality. BC is one of the most frequent causes for bladder removal through radical cystectomy, the gold-standard treatment for localized muscle-invasive and some cases of high-risk, non-muscle-invasive bladder cancer. In order to restore urinary functionality, an autologous intestinal segment has to be used to create a urinary diversion. However, several complications are associated with bowel-tract removal, affecting patients’ quality of life. The present study project aims to develop a bio-engineered material to simplify this surgical procedure, avoiding related surgical complications and improving patients’ quality of life. The main novelty of such a therapeutic approach is the decellularization of a porcine small intestinal submucosa (SIS) conduit to replace the autologous intestinal segment currently used as urinary diversion after radical cystectomy, while avoiding an immune rejection. Here, we performed a preliminary evaluation of this acellular product by developing a novel decellularization process based on an environmentally friendly, mild detergent, i.e., Tergitol, to replace the recently declared toxic Triton X-100. Treatment efficacy was evaluated through histology, DNA, hydroxyproline and elastin quantification, mechanical and insufflation tests, two-photon microscopy, FTIR analysis, and cytocompatibility tests. The optimized decellularization protocol is effective in removing cells, including DNA content, from the porcine SIS, while preserving the integrity of the extracellular matrix despite an increase in stiffness. An effective sterilization protocol was found, and cytocompatibility of treated SIS was demonstrated from day 1 to day 7, during which human fibroblasts were able to increase in number and strongly organize along tissue fibres. Taken together, this in vitro study suggests that SIS is a suitable candidate for use in urinary diversions in place of autologous intestinal segments, considering the optimal results of decellularization and cell proliferation. Further efforts should be undertaken in order to improve SIS conduit patency and impermeability to realize a future viable substitute. 相似文献