Hemispheric Specialization in the Primary Auditory Area of Awake and Anesthetized Starlings (Sturnus vulgaris).

Although evidence exists for a lateralization of song production, few studies have focused on the perceptual aspect of lateralization in songbirds. In the present study, the authors recorded neuronal responses to a variety of species-specific and artificial, nonspecific stimuli in both hemispheres of awake and anesthetized male starlings (Sturnus vulgaris). Recordings were made in the primary auditory area of the songbird brain, the Field L complex. The right hemisphere exhibited significantly more responsive units than the left hemisphere in awake birds, and this difference was significantly reduced in anesthetized birds. Furthermore, clear hemispheric specialization toward categories of behaviorally relevant stimuli and precise parameters of these stimuli were found. The main auditory area of the starling's brain thus appears to show some degree of lateralization. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evidence of sequential lift in growth of aligned multiwalled carbon nanotube multilayers

We synthesized aligned multiwalled carbon nanotube multilayers by aerosol-assisted catalytic chemical vapor deposition through sequential injections of aerosols containing both carbon and catalyst precursors. Each sequence was traced by a specific duration or precursor mixture, with the carbon source being possibly enriched in (13)C isotope labels. We discovered that any sequence involved the growth of a new layer on the substrate surface, under any pre-existing one by lifting it up, giving definitive evidence of a base-growth mechanism.     

Solar operated water-Amonia absorption heat pump for air-conditioning: Modelling and simulation

This study is devoted to the mathematical modelling of an ammoniawater absorption heat pump adapted to solar air-conditioning and including refrigerant and solution storages. Mathematical simulation permits the prediction of the performance of the system during a 24-h period and allows one to estimate its energetic performance, which is compared with those of systems using water-lithium bromide.     

Impact of ultrafiltration and nanofiltration of an industrial fish protein hydrolysate on its bioactive properties

BACKGROUND: Numerous studies have demonstrated that in vitro controlled enzymatic hydrolysis of fish and shellfish proteins leads to bioactive peptides. Ultrafiltration (UF) and/or nanofiltration (NF) can be used to refine hydrolysates and also to fractionate them in order to obtain a peptide population enriched in selected sizes. This study was designed to highlight the impact of controlled UF and NF on the stability of biological activities of an industrial fish protein hydrolysate (FPH) and to understand whether fractionation could improve its content in bioactive peptides. RESULTS: The starting fish protein hydrolysate exhibited a balanced amino acid composition, a reproducible molecular weight (MW) profile, and a low sodium chloride content, allowing the study of its biological activity. Successive fractionation on UF and NF membranes allowed concentration of peptides of selected sizes, without, however, carrying out sharp separations, some MW classes being found in several fractions. Peptides containing Pro, Hyp, Asp and Glu were concentrated in the UF and NF retentates compared to the unfractionated hydrolysate and UF permeate, respectively. Gastrin/cholecystokinin‐like peptides were present in the starting FPH, UF and NF fractions, but fractionation did not increase their concentration. In contrast, quantification of calcitonin gene‐related peptide (CGRP)‐like peptides demonstrated an increase in CGRP‐like activities in the UF permeate, relative to the starting FPH. The starting hydrolysate also showed a potent antioxidant and radical scavenging activity, and a moderate angiotensin‐converting enzyme (ACE)‐1 inhibitory activity, which were not increased by UF and NF fractionation. CONCLUSION: Fractionation of an FPH using membrane separation, with a molecular weight cut‐off adapted to the peptide composition, may provide an effective means to concentrate CGRP‐like peptides and peptides enriched in selected amino acids. The peptide size distribution observed after UF and NF fractionation demonstrates that it is misleading to characterize the fractions obtained by membrane filtration according to the MW cut‐off of the membrane only, as is currently done in the literature. Copyright © 2010 Society of Chemical Industry     

Analyse du comportement d’un sol argileux sous sollicitations hydriques cycliques

Expansive soils swell and shrink regularly when subjected to moisture changes. Clayey soils are available worldwide and are a continual source of concern causing substantial damage to civil engineering structures. Cyclic expansion and shrinkage of clays and associated movements of foundations may result in cracking and fatigue to structures. In France, the damage caused by this phenomenon was estimated to be more than 3.3 billion euros in 2002 (Vincent in 3^ème conférence SIRNAT-Forum des journées pour la Prévention des Risques Naturels, Orléans, janv. 2003) and the Paris region is one of the most affected. The objective of this study is to investigate the swell–shrink behaviour of a natural clayey soil considered to be responsible for a lot of damage observed on buildings in the Paris region, and thus contributing to the characterisation and understanding of expansive clayey soils. The studied soil, Argile verte de Romainville, is a lagoonal-marine deposit and is part of the Paris Basin Tertiary (Oligocene) formations (Fig. 1). It is a clayey soil sampled in the eastern region of Paris. The mineralogical and geotechnical properties of the soil are presented in Table 1. The soil contains quartz (15–20%), carbonates (12–20%) and traces of mica and feldspars. X-ray diffraction showed that carbonates are essentially dolomite and the clay minerals are dominantly illite, kaolinite and a small amount of smectite (Fig. 2). A grain size analysis shows that the clay content (<2 μm) varies between 78 and 80%. The study of its microstructure by means of the scanning electron microscope indicates that the clayey soil has structural elements oriented in the direction of bedding. The structure of the sample generally consisted of dense and continuous clay matrices with very limited visible pore spaces (Fig. 3). At its natural water content (w = 25%), the soil shows mainly a unimodal pore size distribution with an average pore radius of 0.07 μm and a very limited porosity with radii larger than 10 μm (Fig. 4). To assess the effect of suction on the simultaneous changes in void ratio and degree of saturation under zero external stresses, drying–wetting tests are performed on the natural samples. The osmotic technique (Polyethylene glycol solutions) and various salt solutions are used to control the suction values ranging from 1 to 300 MPa. Once equilibrium is reached at the given suction, the samples are weighed and their volume is measured. A synthesis of the drying–wetting paths is given on Fig. 5. The swelling potential of the soil is evaluated using both indirect (or empirical methods Tables 2 and 3) and direct methods. Swell percentage and swell pressure of the soil are measured in a conventional oedometer apparatus according to ASTM (D 4546-85). The test specimens are 70 mm in diameter and the height varies between 12 and 24 mm. The swell percentage is measured under a nominal pressure of 0.7, 2.0 and 6.3 kPa. Swelling pressure of the soil is measured by the conventional consolidation test method (free swell and load, ASTM D 4546-85 method A) and by a constant volume method (ASTM D 4546-85 method C). The test parameters and results for each specimen are given in Tables 4 and 5, and on Fig. 7. Cyclic swell–shrink tests are carried out on similar samples taken from the same monolith. A scheme that permits the study of the clayey soil behaviour at the extreme states of wetting and drying is chosen. The test begins by wetting the samples at their natural moisture content and density. When swelling is stabilized, the water is removed from around the samples and they are dried in an oven maintained at 45°C until the vertical deformation (shrinkage) is stabilised and are then rewetted and so on. Some experiments are stopped at different swelling phases for microstructural study of the soil. The test parameters of the specimens are given in Table 9 and the results are shown in Figs. 9 and 10. The evolution of the microstructure during wetting and drying cycles is investigated using scanning electron microscope and mercury intrusion porosimetry. Observations are made only on soil specimens taken at the end of the swelling phase of the selected cycles. In order to preserve the microstructure, the specimens are cut in small pieces, frozen by liquid nitrogen and finally sublimated. The results of the drying–wetting path including the water retention curve are shown on Fig. 5. The results show that on the drying path (in the void ratio versus water content plane) the soil first follows nearly the saturation line and then, as the water content decreases, the void ratio tends towards a constant value. A shrinkage limit of w = 14.5 % and a corresponding suction value of 15 MPa is deduced from this path. An air entry value of 10 MPa is obtained from degree of saturation versus suction curve. The wetting path shows that the wetting–drying path is reversible for suction values higher than 60 MPa. The different indirect methods used to assess the swelling potential of the Argile verte de Romainville show a general agreement with respect to its swelling potential ranging from high to very high (Table 3). Examination of the free swell test results shows that the Argile verte de Romainville exhibits swell percentage in the range of 15–26% and that its degree of swelling depends on the initial conditions (water content, dry density) and the applied load (Table 4). The higher the water content and the applied load, the lower the swell percentage. A specimen taken parallel to the bedding plane shows similar values of swell percentage with a steep volume change versus time curve indicating an anisotropy of permeability. The two direct methods used to assess the swelling pressure of the Argile verte de Romainville give different values (Table 5). The values obtained by the constant volume method are relatively close and are about 700 kPa. Lower values varying between 360 and 540 kPa are obtained by the conventional consolidation test (free swell-consolidation). This indicates that besides the initial conditions, the swelling pressure is strongly dependent on the stress path followed. The results obtained from the wetting–drying cycle tests show that the magnitude of the first swell cycle is controlled by the initial water content, the maximum deformation occurring on the second cycle and the stabilization of swelling deformation from the third cycle (Figs. 9, 10). Furthermore, the experimental data indicate that upon repeated wetting and drying, the swelling rate of the soil becomes faster, which is explained by an increase in permeability of the soil due to the development of preferential flow paths (micro cracks) on drying. With an increasing number of cycles, a permanent increase in the volume of the samples is observed. This suggests that the swelling–shrinkage behaviour of expansive soils is not completely reversible. Mercury intrusion porosimetry analysis and SEM observations before and after different numbers of cyclic swelling indicate that the swelling–shrinkage cycles are accompanied by a continual reconstruction of the soil structure (Figs. 11, 12). The mercury intrusion porosimetry results show that with an increasing number of wetting–drying cycles the pore volume and the average diameter of the pores increase progressively (Fig. 11). Larger modifications are observed in the pores with radius in the range of 0.1–5 μm. SEM observations also show further destruction of large aggregates and disorientation of structural elements as the number of cycles increases (Fig. 12). After the fifth cycle, the soil original structure is totally lost and a disoriented homogeneous and loose structure with more homogeneous pore spaces is observed (Fig. 12d).      

Preparation of a hydrophobic recycled jute-based nonwoven using a titanium dioxide/stearic acid coating

This work aims at developing a hydrophobic treatment for jute fiber-based nonwovens. Three solutions of titanium dioxide (TiO₂) nanoparticles were prepared through a sol–gel method by varying the molar ratio of the various constituents. The nonwoven was pretreated with these solutions before being impregnated with different concentrations of stearic acid. The TiO₂ nanoparticles synthesized are amorphous; their size varies with the concentration of ethanol used as a solvent in the sol–gel method. The nanoparticle coating produced on the jute fibers is uniform. The nonwoven wettability was evaluated by measuring its water contact angle and retention time; the nonwoven became hydrophobic at the lowest fatty acid concentration tested. An increase in the stability of the hydrophobicity was observed when the TiO₂ nanoparticle pretreatment was used compared to the application of the stearic acid treatment only. No detrimental effect of the hydrophobic treatment on the nonwoven mechanical performance and thermal stability was observed. These results demonstrate the potential of the TiO₂ nanoparticle/stearic acid treatment as a fast method to provide a stable hydrophobicity to recycled jute-based nonwovens.     

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

The 2-oxoglutarate-dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templates for PHD inhibition is limited. We report structure–activity relationship and crystallographic studies on a promising class of 4-hydroxypyrimidine-containing PHD inhibitors.     

Natural food mastication capability in preschool children according to their oral condition: A preliminary study

This study investigated, for the first time, the masticatory capability of preschool children using natural foods, and the impact of an early oral health alteration (early childhood caries: ECC) on the granulometry of ready-to-swallow food boluses. Thirteen children with ECC were compared to 13 preschool children with a healthy oral condition. Oral health criteria and NOT-S scores (Nordic Orofacial dysfunction Test-Screening) were recorded. For each child, number of masticatory cycles (Nc), chewing time (Ti), and frequency (Fq = Nc/Ti) were recorded during mastication of raw carrot (CAR), cheese (CHS) and breakfast cereals (CER) samples. Food boluses were collected by stopping children at their food-dependent individual swallowing threshold (Nc), and the median food bolus particle size value (D50) was calculated. Correlations were sought between oral health and masticatory criteria. In the ECC group, mean Fq values were significantly decreased for all three foods (p ≤ .001) and mean D50 values were significantly increased (p ≤ .001) compared to the control group (i.e., D50 CAR = 4,384 μm ± 929 vs. 2,960 μm ± 627). These alterations were related to the extent of ECC. The NOT-S mean global score was significantly increased in children with ECC (2.62 ± 1.37 vs. 1 ± 0.91 in the control group, p ≤ .01), due to “Mastication and swallowing” domain impairment. This study gives granulometric normative values for three foods in preschool children and shows the impact of ECC on D50 values. The progression of children's masticatory capability after dental treatment, and the impact of such modifications of sensory input on future eating habits should be explored.     

Microfluidics as an Enabling Technology for Personalized Cancer Therapy

Tailoring patient‐specific treatments for cancer is necessary in order to achieve optimal results but requires new diagnostic approaches at affordable prices. Microfluidics has immense potential to provide solutions for this, as it enables the processing of samples that are not available in large quantities (e.g., cells from patient biopsies), is cost efficient, provides a high level of automation, and allows the set‐up of complex models for cancer studies. In this review, individual solutions in the fields of genetics, circulating tumor cell monitoring, biomarker analysis, phenotypic drug sensitivity tests, and systems providing controlled environments for disease modeling are discussed. An overview on how these early stage achievements can be combined or developed further is showcased, and the required translational steps before microfluidics becomes a routine tool for clinical applications are critically discussed.