HOPSCA外部空间环境设计初探——以深圳市宝能笋岗物流中心城市综合体项目为例

本文以深圳市宝能笋岗物流中心城市综合体项目为例,从HOPSCA外部空间环境与城市要素的关系出发,具体结合项目基地本身的城市特质,遵循外部空间环境设计的原则,采用现代建筑的设计策略与手法,而满足城市综合体中各种要求。本文尤其关注如何将城市要素真正融入到现代城市综合体设计当中,创造出真正城市的建筑。     

Distribution of major and minor alkaloids in tobacco, mainstream and sidestream smoke of popular Indian smoking products

Various Indian smoking products--cigarette, bidi, chutta and a brand of US cigarette--were analysed by gas chromatography-flame ionization detection (GC-FID) for the levels of nicotine and minor tobacco alkaloids in tobacco, mainstream smoke (MS) and sidestream smoke (SS) employing modified smoking standards, namely two puffs/min. The analysis clearly demonstrated relatively higher levels of nicotine and minor tobacco alkaloids in tobacco from bidi (37.7 mg/g) and chutta (34.5 mg/g) when compared with Indian and US cigarettes (14-16 mg/g) studied. Relatively lower levels (SS/MS) of nicotine in SS from bidi and chutta compared with Indian/US cigarettes, suggest that the contribution of nicotine in SS from a single bidi/chutta to environmental tobacco smoke (ETS) is very much less than that of a single Indian/US cigarette. Reduced levels of nicotine in SS of bidi/chutta result in relatively higher deliveries of nicotine in MS as reflected by higher MS/SS values. The observed differences are likely to be due to difference in tobacco processing, burning rate/temperature and design of the smoking product.     

Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies

OBJECTIVE: To analyze the effects of flutamide in patients with physical and/or mental disorders consulting for urinary symptoms secondary to benign prostatic hyperplasia (BPH). METHODS: 50 patients with BPH in whom surgical treatment was contraindicated due to their physical and/or mental condition were treated with flutamide 250 mg/day. Four patients presented with urinary retention and 46 patients had prostatic symptomatology. Patients were evaluated using the symptoms score (I-PSS) and quality of life (QL). Prostate volume was measured by transabdominal US; the maximum flow rate at spontaneous micturition and residual urine were determined. RESULTS: At 12 months, the I-PSS and QL scores decreased by a mean of 7 and 3 points, respectively. The US demonstrated that treatment had reduced prostatic volume by a mean of 10 gms. The maximum flow rate at spontaneous micturition increased 3 ml/sec and residual urine decreased by 15 ml. CONCLUSION: Flutamide is another alternative to surgery in specific patients with BPH.     

BCR-ABL induces neurite-like structures and BCR lacking the SH2-binding domain induces cell rounding in PC12 cells

The activated tyrosine kinase oncoprotein BCR-ABL is responsible for pathogenesis of Philadelphia chromosome-positive human leukemias. Because BCR carries a GAP (GTPase-activating protein) activity toward cytoskeleton-related small GTP-binding proteins, we utilized a neuronal PC12 cell system to test morphogenic potentials of BCR-ABL or BCR. We report here unique morphological phenotypes of PC12 cells expressing either BCR-ABL or a BCR mutant which lacks the SH2-binding domain (BCR Delta162-413). Although MAP kinase was not activated in PC12 cells expressing BCR-ABL, they showed incomplete neurite extensions even in the absence of the nerve growth factor (NGF). Overproduction of BCR Delta162-413 in PC12 cells, on the other hand, induced cell rounding in the absence of NGF. Interestingly, those cells could hardly make terminal differentiation in the presence of NGF and continued to grow without changing their round shape, although NGF receptor as well as MAP kinase appeared to be activated. Interestingly, the botulinum C3 toxin induced neurite-like structures in PC12 cells overexpressing BCR Delta162-413 without NGF.     

Integrated Wavelength-Insensitive Differential Laser Doppler Velocimeter Using Planar Lightwave Circuit

In this paper, a design of an integrated wavelength-insensitive laser Doppler velocimeter (LDV) has been proposed using planar lightwave circuit (PLC). The proposed LDV uses arrayed waveguide gratings (AWGs) that can be fabricated using PLC technology. Its characteristics are simulated using a design model based on grating equations for AWGs. The simulation results indicate that wavelength-insensitive operation can be almost obtained by optimizing the design parameters of the proposed structure without assembly of bulk diffractive gratings or other optical elements.     

浅谈体验式商业建筑空间——以"青岛·十五街"为例

当前商业空间正在日益强劲地朝着体验式商业模式的方向发展,它从顾客的情感体验出发,通过人性化开放式空间的设计,打造一种融文化,娱乐、休闲等为一体的互动式综合性街区.文章以"青岛·十五街"的商业规划和设计理念为例,结合实际调研,解析了体验式商业建筑空间的内涵.     

RNA Dynamics by NMR Spectroscopy

An ever-increasing number of functional RNAs require a mechanistic understanding. RNA function relies on changes in its structure, so-called dynamics. To reveal dynamic processes and higher energy structures, new NMR methods have been developed to elucidate these dynamics in RNA with atomic resolution. In this Review, we provide an introduction to dynamics novices and an overview of methods that access most dynamic timescales, from picoseconds to hours. Examples are provided as well as insight into theory, data acquisition and analysis for these different methods. Using this broad spectrum of methodology, unprecedented detail and invisible structures have been obtained and are reviewed here. RNA, though often more complicated and therefore neglected, also provides a great system to study structural changes, as these RNA structural changes are more easily defined—Lego like—than in proteins, hence the numerous revelations of RNA excited states.     

Effect of lubricant viscosity grade on mechanical vibration of roller bearings

This work aims to characterize vibration behavior of roller bearings as a function of lubricant viscosity. Experimental tests were performed in NU205 roller bearings, lubricated with mineral oil of three different viscosity grades (ISO 10, 32 and 68). The mechanical vibration was determined through the processing and analysis of bearing radial vibration data, obtained from each of the lubrication conditions, during 2 h of test run for temperature stabilization and under several bearing shaft speeds. The applied radial load was 10% of the bearing nominal load. Through root mean square (RMS) analysis of the vibration signals, it was possible to identify specific frequency bands modulated by the change in lubricant viscosity, which was related to change in oil film thickness.     

自由生长的西藏传统建筑——西藏传统建筑布局与空间形态初探

西藏传统建筑特点很多,就其分布而言,主要有两种方式:一、河谷平原分布,二、依山而建.西藏建筑在这两种分布方式下均呈现出自由生长的态势,一方面与其独特的地形地貌和人文精神有关,另一方面也直接影响着西藏传统建筑在空间布局与立面造型上表现出灵活、不对称特征.在现代建筑设计中我们应该借鉴西藏传统建筑内部空间组织与外部形态特点,创造出符合藏式建筑空间神韵的建筑.     

南岳区区治大院设计探索

本以南岳区区治大院工程设计为实例，提出了在近代历史风景名城进行建筑创作所考虑的原则和理念，并加以解析。