Planning of randomized early detection trials

Consider a randomized clinical trial to evaluate the benefit of screening an asymptomatic population. Suppose that the subjects are randomized into a usual care and a study group. The study group receives one or more periodic early detection examinations aimed at diagnosing disease early, when there are no signs or symptoms. Early detection clinical trials differ from therapeutic trials in that power is affected by: i) the number of exams, ii) the time between exams and iii) the ages at which exams will be given. These design options do not exist in therapeutic trials. Furthermore; long-term follow-up may result in a reduction of power. In general, power increases with number of examinations, and the optimal follow-up time is dependent on the spacing between examinations. Clinical trials in which the usual care group receives benefit are also discussed. Two designs are discussed, for example the 'up-front design' in which all subjects receive an initial exam and then are randomized to the usual care and study groups and the 'close-out design' in which the usual care group receives an exam which is timed to be given at the same time as the last exam in the study group. Both families of designs significantly reduce the power. Power calculations are made for two clinical trials, which actually used these two designs.     

Relations among scores on Edwards Personal Preference Schedule, California Psychological Inventory, and Strong Vocational Interest Blank for an industrial sample.

The significant intercorrelations among scores on the EPPS, the CPI, and the SVIB are reported for a group of 102 salaried employees of the 3M Company. Comparison of the CPI and EPPS scales generally shows correlations in the expected directions, and correlations between occupational interests and personality variables make "good clinical sense." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Birth order and family size of homosexual men and women.

Systematically compared the birth order and family size of 150 male and 99 female homosexuals with those of 108 male and 97 female heterosexuals. Results show that neither birth order nor family size represented distinct or meaningful contrasts between male or female homosexuals or heterosexuals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Phase retrieval in digital speckle pattern interferometry by use of a smoothed space-frequency distribution

We evaluate the use of a smoothed space-frequency distribution (SSFD) to retrieve optical phase maps in digital speckle pattern interferometry (DSPI). The performance of this method is tested by use of computer-simulated DSPI fringes. Phase gradients are found along a pixel path from a single DSPI image, and the phase map is finally determined by integration. This technique does not need the application of a phase unwrapping algorithm or the introduction of carrier fringes in the interferometer. It is shown that a Wigner-Ville distribution with a smoothing Gaussian kernel gives more-accurate results than methods based on the continuous wavelet transform. We also discuss the influence of filtering on smoothing of the DSPI fringes and some additional limitations that emerge when this technique is applied. The performance of the SSFD method for processing experimental data is then illustrated.     

Vibration-induced phase errors in high-speed phase-shifting speckle-pattern interferometry

We present results from numerical simulations of a dynamic phase-shifting speckle interferometer used in the presence of mechanical vibrations. The simulation is based on a detailed mathematical model of the system, which is used to predict the expected frequency response of the rms measurement error, in the time-varying phase difference maps, as a result of vibration. The performance of different phase-shifting algorithms is studied over a range of vibrational frequencies. Phase-difference evaluation is performed by means of temporal phase shifting and temporal phase unwrapping. It is demonstrated that longer sampling windows and higher framing rates are preferred in order to reduce the phase-change error that is due to vibration. A numerical criterion for an upper limit on the length of time window for the phase-shifting algorithm is also proposed. The numerical results are finally compared with experimental data, acquired with a phase-shifting speckle interferometer of 1000 frames/s.     

Linear-Time Algorithms for Hole-free Rectilinear Proportional Contact Graph Representations

In a proportional contact representation of a planar graph, each vertex is represented by a simple polygon with area proportional to a given weight, and edges are represented by adjacencies between the corresponding pairs of polygons. In this paper we first study proportional contact representations that use rectilinear polygons without wasted areas (white space). In this setting, the best known algorithm for proportional contact representation of a maximal planar graph uses 12-sided rectilinear polygons and takes O(nlogn) time. We describe a new algorithm that guarantees 10-sided rectilinear polygons and runs in O(n) time. We also describe a linear-time algorithm for proportional contact representation of planar 3-trees with 8-sided rectilinear polygons and show that this is optimal, as there exist planar 3-trees that require 8-sided polygons. We then show that a maximal outer-planar graph admits a proportional contact representation using rectilinear polygons with 6 sides when the outer-boundary is a rectangle and with 4 sides otherwise. Finally we study maximal series-parallel graphs. Here we show that O(1)-sided rectilinear polygons are not possible unless we allow holes, but 6-sided polygons can be achieved with arbitrarily small holes.     

Spectral and radiometric requirements for the airborne thermal imaging spectrometer ARES

ARES (Airborne Reflective/Emissive Spectrometer) is an airborne imaging spectrometer for remote sensing of land surfaces covering the wavelength regions 0.45–2.45?µm and 8–13?µm with 160 channels. The instrument is being built by Integrated Spectronics, financed by DLR and GFZ, and will be available to the scientific community from 2005 on.

This contribution presents the design of the thermal spectrometer covering the 8–13?µm region with 32 channels of 150?nm bandwidth while a separate paper treats the instrument specifications in the solar reflective region. The spectro‐radiometric design is based on scientific requirements derived from application scenarios comprising vegetation, soils of different compositions, and mineral exploration. The corresponding emissivity spectra are input for a simulation model that calculates at‐sensor radiance spectra, resamples them with the channel‐specific response functions, adds different amounts of sensor noise to the signal, and performs a retrieval to get the corresponding noisy surface emissivity spectra. The results of the simulation study indicate that a spectral wavelength accuracy of 3?nm and a sensor noise equivalent temperature of 0.05–0.1?K are required for an accurate retrieval of emissivity spectra.