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排序方式: 共有3794条查询结果,搜索用时 15 毫秒
91.
Joseph Berry Tonio Buonassisi David A. Egger Gary Hodes Leeor Kronik Yueh‐Lin Loo Igor Lubomirsky Seth R. Marder Yitzhak Mastai Joel S. Miller David B. Mitzi Yaron Paz Andrew M. Rappe Ilan Riess Boris Rybtchinski Oscar Stafsudd Vladan Stevanovic Michael F. Toney David Zitoun Antoine Kahn David Ginley David Cahen 《Advanced materials (Deerfield Beach, Fla.)》2015,27(35):5102-5112
92.
Pamidimarri D.V.N. Sudheer Yokimiko David Cheol Gi Chae You Jin Kim Mary Grace Baylon Kei-Anne Baritugo Tae Wan Kim Min-Sik Kim Jeong Geol Na Si Jae Park 《Korean Journal of Chemical Engineering》2016,33(10):2788-2801
Coal, the most primitive fossil fuel, has been exploited for ages, and reserves dictate the economies of many countries. Presently, most energy is generated by direct combustion, raising concerns over global warming. Biological pretreatment of fossil resources and generation of alternative green energy can address the environmental issues associated with global coal utilization. Biological coal treatment can produce industrially important chemicals and bio-methane by employing microorganisms able to depolymerize/degrade coal. This review discusses current advances in microbial coal conversion, such as the efforts made to comprehend microbial processes, significant outputs of coal conversion, principle components responsible for coal conversion, and factors affecting the biological processes to convert coal. Development of these biological processes can be a stepping stone for greener coal; however, integration of multidisciplinary technologies is needed to increase the efficiency of economic coal utilization and production of economically and industrially feasible biomethane. 相似文献
93.
Naira V. Margaryan Alina Gilgur Elisabeth A. Seftor Chad Purnell Nicoleta C. Arva Arun K. Gosain Mary J. C. Hendrix Luigi Strizzi 《International journal of molecular sciences》2016,17(3)
Expression of Nodal, a Transforming Growth Factor-beta (TGF-β) related growth factor, is associated with aggressive melanoma. Nodal expression in adult dysplastic nevi may predict the development of aggressive melanoma in some patients. A subset of pediatric patients diagnosed with giant or large congenital melanocytic nevi (LCMN) has shown increased risk for development of melanoma. Here, we investigate whether Nodal expression can help identify the rare cases of LCMN that develop melanoma and shed light on why the majority of these patients do not. Immunohistochemistry (IHC) staining results show varying degree of Nodal expression in pediatric dysplastic nevi and LCMN. Moreover, median scores from Nodal IHC expression analysis were not significantly different between these two groups. Additionally, none of the LCMN patients in this study developed melanoma, regardless of Nodal IHC levels. Co-culture experiments revealed reduced tumor growth and lower levels of Nodal and its signaling molecules P-SMAD2 and P-ERK1/2 when melanoma cells were grown in vivo or in vitro with normal melanocytes. The same was observed in melanoma cells cultured with melanocyte conditioned media containing pigmented melanocyte derived melanosomes (MDM). Since MDM contain molecules capable of inactivating radical oxygen species, to investigate potential anti-oxidant effect of MDM on Nodal expression and signaling in melanoma, melanoma cells were treated with either N-acetyl-l-cysteine (NAC), a component of the anti-oxidant glutathione or synthetic melanin, which in addition to providing pigmentation can also exert free radical scavenging activity. Melanoma cells treated with NAC or synthetic melanin showed reduced levels of Nodal, P-SMAD2 and P-ERK1/2 compared to untreated melanoma cells. Thus, the potential role for Nodal in melanoma development in LCMN is less evident than in adult dysplastic nevi possibly due to melanocyte cross-talk in LCMN capable of offsetting or delaying the pro-melanoma effects of Nodal via anti-oxidant effects of MDM. 相似文献
94.
Mary W. Stoertz Heather Bourne Christa Knotts Matthew M. White 《Mine Water and the Environment》2002,21(2):60-72
Isolated headwater streams in mined watersheds may have good water quality and fish habitat, yet be disconnected from immigration
sources by stream segments impaired by acid mine drainage (AMD). Studies of fish and macroinvertebrate communities, habitat,
and a number of hydrochemical parameters in Monday Creek, Ohio, show that AMD eliminates fish communities and severely limits
macroinvertebrate communities in directly affected tributaries. Isolated headwaters in the heavily mined Monday Creek watershed
have relatively good water quality and habitat, but poor fish communities. Comparison of isolated Monday Creek headwaters
with non-isolated reaches in unmined watersheds indicates that differences in fish communities are attributable to isolation.
Fish communities in isolated headwaters have lower Indices of Biotic Integrity (IBI) than comparable non-isolated communities,
reduced species numbers, and lower numbers of individuals, despite suitable habitat as measured by the Qualitative Habitat
Evaluation Index (QHEI). Comparison of macroinvertebrate communities shows higher Invertebrate Community Indices (ICI), and
no apparent species loss, which can be attributed to the obligate flight stage in the life cycle of many macroinvertebrates,
which enables them to overcome aquatic barriers. The implication of this research is that there is an opportunity for recovery
of depleted fish communities in large AMD-isolated areas with good water quality, suitable habitat, and intact macroinvertebrate
communities, by downstream treatment or source control of AMD to create aquatic corridors for fish immigration. 相似文献
95.
96.
Raman spectroscopic and conductivity studies show that pyridinium derivatives of the TlCl52⊖, TlCl63⊖ and Tl2Cl93⊖ species dissociate in ethanol solution to yield the TlCl4⊖ ion, but the [(C2H5)4N]2TlCl5 salt does not dissociate further and behaves like a 2:1 electrolyte. 相似文献
97.
Garrett Jones Tae Jin Lee Joshua Glass Grace Rountree Lane Ulrich Amy Estes Mary Sezer Wenbo Zhi Shruti Sharma Ashok Sharma 《International journal of molecular sciences》2022,23(4)
The tear film is a multi-layer fluid that covers the corneal and conjunctival epithelia of the eye and provides lubrication, nutrients, and protection from the outside environment. Tear fluid contains a high concentration of proteins and has thus been recognized as a potential source of biomarkers for ocular disorders due to its proximity to disease sites on the ocular surface and the non-invasive nature of its collection. This is particularly true in the case of dry eye disease, which directly impacts the tear film and its components. Proteomic analysis of tear fluid is challenging mainly due to the wide dynamic range of proteins and the small sample volumes. However, recent advancements in mass spectrometry have revolutionized the field of proteomics enabling unprecedented depth, speed, and accuracy, even with small sample volumes. In this study using the Orbitrap Fusion Tribrid mass spectrometer, we compared four different mass spectrometry workflows for the proteomic analysis of tear fluid collected via Schirmer strips. We were able to establish a method of in-strip protein digestion that identified >3000 proteins in human tear samples from 11 healthy subjects. Our method offers a significant improvement in the number of proteins identified compared to previously reported methods without pooling samples. 相似文献
98.
99.
100.
Erin Vanessa LaRae Smith Rebecca Maree Dyson Christina M. G. Vanderboor Ousseynou Sarr Jane Anderson Mary J. Berry Timothy R. H. Regnault Lifeng Peng Clint Gray 《International journal of molecular sciences》2022,23(2)
Excess dietary fructose is a major public health concern, yet little is known about its influence on offspring development and later-life disease when consumed in excess during pregnancy. To determine whether increased maternal fructose intake could have long-term consequences on offspring health, we investigated the effects of 10% w/v fructose water intake during preconception and pregnancy in guinea pigs. Female Dunkin Hartley guinea pigs were fed a control diet (CD) or fructose diet (FD; providing 16% of total daily caloric intake) ad libitum 60 days prior to mating and throughout gestation. Dietary interventions ceased at day of delivery. Offspring were culled at day 21 (D21) (weaning) and at 4 months (4 M) (young adult). Fetal exposure to excess maternal fructose intake significantly increased male and female triglycerides at D21 and 4 M and circulating palmitoleic acid and total omega-7 through day 0 (D0) to 4 M. Proteomic and functional analysis of significantly differentially expressed proteins revealed that FD offspring (D21 and 4 M) had significantly increased mitochondrial metabolic activities of β-oxidation, electron transport chain (ETC) and oxidative phosphorylation and reactive oxygen species production compared to the CD offspring. Western blotting analysis of both FD offspring validated the increased protein abundances of mitochondrial ETC complex II and IV, SREBP-1c and FAS, whereas VDAC1 expression was higher at D21 but lower at 4 M. We provide evidence demonstrating offspring programmed hepatic mitochondrial metabolism and de novo lipogenesis following excess maternal fructose exposure. These underlying asymptomatic programmed pathways may lead to a predisposition to metabolic dysfunction later in life. 相似文献