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81.
82.
Sahu BS Delachat F Slaoui A Carrada M Ferblantier G Muller D 《Nanoscale research letters》2011,6(1):178
In this study, a wide range of a-SiN
x
:H films with an excess of silicon (20 to 50%) were prepared with an electron-cyclotron resonance plasma-enhanced chemical
vapor deposition system under the flows of NH3 and SiH4. The silicon-rich a-SiN
x
:H films (SRSN) were sandwiched between a bottom thermal SiO2 and a top Si3N4 layer, and subsequently annealed within the temperature range of 500-1100°C in N2 to study the effect of annealing temperature on light-emitting and charge storage properties. A strong visible photoluminescence
(PL) at room temperature has been observed for the as-deposited SRSN films as well as for films annealed up to 1100°C. The
possible origins of the PL are briefly discussed. The authors have succeeded in the formation of amorphous Si quantum dots
with an average size of about 3 to 3.6 nm by varying excess amount of Si and annealing temperature. Electrical properties
have been investigated on Al/Si3N4/SRSN/SiO2/Si structures by capacitance-voltage and conductance-voltage analysis techniques. A significant memory window of 4.45 V was
obtained at a low operating voltage of ± 8 V for the sample containing 25% excess silicon and annealed at 1000°C, indicating
its utility in low-power memory devices. 相似文献
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84.
S Mani JW Kugler DF Sciortino JC Garcia RH Ansari R Humerickhouse F Michelassi MC Posner KL Shulman RL Schilsky M List EE Vokes S Benner 《Canadian Metallurgical Quarterly》1998,9(9):1035-1037
BACKGROUND/OBJECTIVES: Uracil and tegafur in a 4:1 molar concentration ratio (UFT; Bristol-Myers Squibb, Wallingford, CT) has broad anti-tumor activity for cancers arising from the gastrointestinal tract. However, there are no published data regarding the efficacy of leucovorin-modulated UFT in patients with pancreatic cancer. The objective of this trial was to determine the activity and evaluate the toxicity of UFT plus oral calcium leucovorin in patients with advanced pancreatic adenocarcinoma. PATIENTS AND METHODS: Fourteen patients with advanced measurable adenocarcinoma of the pancreas were enrolled onto the trial. Patients received 300 mg/m2/d UFT plus 90 mg/d leucovorin administered orally in divided doses every eight hours for 28 days repeated every 35 days. Objective tumor response was evaluated after two courses of therapy. RESULTS: Fourteen patients were evaluable for response and toxicity. No objective responses were seen. The median (range) time to progression and survival were 14 (1.6-37), and 15 (1.9-62) weeks, respectively. Toxicity was mild with severe (grade 3 or 4) hyperbilirubinemia, pain, diarrhea, transaminitis, venous thrombus, weakness, renal failure, confusion, and edema/ascites seen in three (21%), one (7%), two (14%), one (7%), one (7%), one (7%), one (7%), one (7%), and two (14%) patients, respectively. CONCLUSION: In the 14 patients evaluable, UFT 300 mg/m2/d plus oral leucovorin 90 mg/d administered for 28 days did not demonstrate anti-tumor activity against advanced pancreatic adenocarcinoma; however, this oral regimen was well tolerated and devoid of neutropenia, significant oral mucositis or diarrhea. 相似文献
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Michela Campolo Marika Lanza Irene Paterniti Alessia Filippone Alessio Ardizzone Giovanna Casili Sarah A. Scuderi Caterina Puglisi Marzia Mare Lorenzo Memeo Salvatore Cuzzocrea Emanuela Esposito 《International journal of molecular sciences》2021,22(8)
Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics, such as oxaliplatin (L-OHP). The aim of the present work was to evaluate the potential beneficial effects of 2-pentadecyl-2-oxazoline (PEA-OXA) in a murine model of oxaliplatin-induced peripheral neuropathy (OIPN). OIPN was induced by an intraperitoneally injection of L-OHP in rats on five consecutive days (D0–4) for a final cumulative dose of 10 mg/kg. PEA-OXA and ultramicronized palmitoylethanolamide (PEAum), both 10 mg/kg, were given orally 15–20 min prior (L-OHP) and sacrifice was made on day 25. Our results demonstrated that PEA-OXA, more than PEAum, reduced the development of hypersensitivity in rats; this was associated with the reduction in hyperactivation of glia cells and the increased production of proinflammatory cytokines in the dorsal horn of the spinal cord, accompanied by an upregulation of neurotrophic factors in the dorsal root ganglia (DRG). Moreover, we showed that PEA-OXA reduced L-OHP damage via a reduction in NF-κB pathway activation and a modulation of Nrf-2 pathways. Our findings identify PEA-OXA as a therapeutic target in chemotherapy-induced painful neuropathy, through the biomolecular signaling NF-κB/Nrf-2 axis, thanks to its abilities to counteract L-OHP damage. Therefore, we can consider PEA-OXA as a promising adjunct to chemotherapy to reduce chronic pain in patients. 相似文献
87.
Chiara Degli Esposti Barbara Iadarola Simone Maestri Cristina Beltrami Denise Lavezzari Martina Morini Patrizia De Marco Giovanni Erminio Alberto Garaventa Federico Zara Massimo Delledonne Marzia Ognibene Annalisa Pezzolo 《International journal of molecular sciences》2021,22(7)
Neuroblastoma (NB) is an aggressive infancy tumor, leading cause of death among preschool age diseases. Here we focused on characterization of exosomal DNA (exo-DNA) isolated from plasma cell-derived exosomes of neuroblastoma patients, and its potential use for detection of somatic mutations present in the parental tumor cells. Exosomes are small extracellular membrane vesicles secreted by most cells, playing an important role in intercellular communications. Using an enzymatic method, we provided evidence for the presence of double-stranded DNA in the NB exosomes. Moreover, by whole exome sequencing, we demonstrated that NB exo-DNA represents the entire exome and that it carries tumor-specific genetic mutations, including those occurring on known oncogenes and tumor suppressor genes in neuroblastoma (ALK, CHD5, SHANK2, PHOX2B, TERT, FGFR1, and BRAF). NB exo-DNA can be useful to identify variants responsible for acquired resistance, such as mutations of ALK, TP53, and RAS/MAPK genes that appear in relapsed patients. The possibility to isolate and to enrich NB derived exosomes from plasma using surface markers, and the quick and easy extraction of exo-DNA, gives this methodology a translational potential in the clinic. Exo-DNA can be an attractive non-invasive biomarker for NB molecular diagnostic, especially when tissue biopsy cannot be easily available. 相似文献
88.
Shamim Mahbub Marzia Rahman Shahed Rana Malik Abdul Rub Md. Anamul Hoque Mohammed Abdullah Khan Abdullah M. Asiri 《Journal of surfactants and detergents》2019,22(1):137-152
A conductometric study of the mixed micellization behavior between cetyltrimethylammonium bromide (CTAB, a cationic surfactant) and sodium dodecyl sulfate (SDS, an anionic surfactant) was carried out in the absence/presence of various percentages of chitosan in the temperature range of 298.15–318.15 K. The deviations of critical micelle concentration (cmc) from the ideal values indicate the interaction between CTAB and SDS. The micellar mole fraction values according to different proposed models X1Rub (Rubingh), X1M (Motomura), X1Rod (Rodenas), and X1id (ideal mole fraction) were estimated and the results obtained reveal the high contribution of CTAB in the mixed micellization, which enhances with the increase of the mole fraction of CTAB. The negative magnitudes of indicate the spontaneous formation of mixed micelles between CTAB and SDS. The values of activity coefficients (f1 and f2) were less than unity and the values of the interaction parameter (β) are negative in all cases, which indicate the attractive interaction between CTAB and SDS. The negative values of excess free energy of micellization (ΔGex) signify the stability of the mixed micelles. The negative values of in the chitosan systems indicate that micellization is exothermic. The values of were found to be positive in all cases. 相似文献
89.
Alessia DAloia Laura Molteni Francesca Gullo Elena Bresciani Valentina Artusa Laura Rizzi Michela Ceriani Ramona Meanti Marzia Lecchi Silvia Coco Barbara Costa Antonio Torsello 《International journal of molecular sciences》2021,22(6)
Palmitoylethanolamide (PEA) is an endogenous lipid produced on demand by neurons and glial cells that displays neuroprotective properties. It is well known that inflammation and neuronal damage are strictly related processes and that microglia play a pivotal role in their regulation. The aim of the present work was to assess whether PEA could exert its neuroprotective and anti-inflammatory effects through the modulation of microglia reactive phenotypes. In N9 microglial cells, the pre-incubation with PEA blunted the increase of M1 pro-inflammatory markers induced by lipopolysaccharide (LPS), concomitantly increasing those M2 anti-inflammatory markers. Images of microglial cells were processed to obtain a set of morphological parameters that highlighted the ability of PEA to inhibit the LPS-induced M1 polarization and suggested that PEA might induce the anti-inflammatory M2a phenotype. Functionally, PEA prevented Ca2+ transients in both N9 cells and primary microglia and antagonized the neuronal hyperexcitability induced by LPS, as revealed by multi-electrode array (MEA) measurements on primary cortical cultures of neurons, microglia, and astrocyte. Finally, the investigation of the molecular pathway indicated that PEA effects are not mediated by toll-like receptor 4 (TLR4); on the contrary, a partial involvement of cannabinoid type 2 receptor (CB2R) was shown by using a selective receptor inverse agonist. 相似文献
90.