Enzyme-linked immunosorvent assay using vertical microreactor stack with microbeads

The advantages of vertical microreactor stack with three-dimensional (3D) structure for immunoassay are discussed. The vertical microreactor stack uses vertical fluid flow operation with multifunctional fluid filters. The multi function of fluid filter is very effective for micromixing and passive valve operation. The mechanism of micromixing is discussed by using computational fluid dynamics (CFD), and we know that the mixing mechanism based on Coanda effect. To evaluate the micromixing performance of fluid filter, we demonstrated enzyme reaction with unique repeat mixing operation. As the results, we proved that the fluid filter has very effective mixing performance. The detection limit, which demonstrated by competition enzyme-linked immunosorvent assay (ELISA), is comparable with recommended detection limit, which suggested by Japanese ministry for the environment.     

Three-dimensional medical image recognition of cancer of the liver by a revised radial basis function (RBF) neural network algorithm

In this study, we propose a revised radial basis function (RBF) neural network algorithm and apply this algorithm to computer-aided diagnosis (CAD) of the liver. First, the revised RBF neural network algorithm is applied to recognition of the liver regions, and the recognition results are compared with those obtained using the conventional RBF neural network and the conventional multilayered neural network trained using the back-propagation algorithm. It is shown that the revised RBF neural network is accurate, and is a useful method because the parameters are automatically determined. Then, the revised RBF neural network is applied to CAD of the liver cancer called hepatocellular carcinoma (HCC).     

Microstructure and properties of (Sr, Ca)CuO2/(Sr, Ca)RuO3 multilayers

Epitaxial multilayer thin films of infinite-layer (Sr, Ca)CuO₂ and perovskite (Sr, Ca)RuO₃ have been prepared on (100) SrTiO₃ substrates by multitarget rf magnetron sputtering. X-ray diffraction analyses revealed that the multilayer structure of (Sr, Ca)CuO₃/(Sr, Ca)RuO₃ was successfully fabricated with a minimum layer thickness of 20 Å. Transmission electron microscopy measurements of the multilayers indicated that there was no dislocation which normally exists in single-layer films with an infinite-layer structure. Resistivities of multilayer films at room temperature ranged from 1 to 10 m cm and showed semiconductor-like dependence against the temperature.     

High-performance and highly stable 0.3-nm-full-width-at-half-maximum interference optical filters

Fabrication of very-narrow-bandpass optical tunable filters [(0.3 nm full width at half-maximum) (FWHM)] is reported. To improve the film densities, the O(2) ion-assisted deposition-method is used in the fabrication. In the succession of high- and low-refractive-index layers, the commonly used TiO(2) material is replaced by Ta(2)O(5), which suits the ion-assisted fabrication technique. The relative thicknesses of the filter multilayer structure of 1/2/1 are modified to 0.998/2.007/0.998, which reduces the shift difference in the central wavelengths with regard to the p and s polarizations when the filter is tilted. These improvements enabled fabrication of 0.3-nm-FWHM optical tunable filters with improved stability characteristics.     

Rational Filters for Passive Depth from Defocus

A fundamental problem in depth from defocus is the measurement of relative defocus between images. The performance of previously proposed focus operators are inevitably sensitive to the frequency spectra of local scene textures. As a result, focus operators such as the Laplacian of Gaussian result in poor depth estimates. An alternative is to use large filter banks that densely sample the frequency space. Though this approach can result in better depth accuracy, it sacrifices the computational efficiency that depth from defocus offers over stereo and structure from motion. We propose a class of broadband operators that, when used together, provide invariance to scene texture and produce accurate and dense depth maps. Since the operators are broadband, a small number of them are sufficient for depth estimation of scenes with complex textural properties. In addition, a depth confidence measure is derived that can be computed from the outputs of the operators. This confidence measure permits further refinement of computed depth maps. Experiments are conducted on both synthetic and real scenes to evaluate the performance of the proposed operators. The depth detection gain error is less than 1%, irrespective of texture frequency. Depth accuracy is found to be 0.51.2% of the distance of the object from the imaging optics.     

Effect of poly(acrylic acid) on the preparation of thick silica films by electrophoretic sol–gel deposition of re-dispersed silica particles

Thick silica films were prepared by the electrophoretic sol–gel deposition technique in the presence of poly(acrylic acid) (PAA) using monodispersed silica particles; the particles were prepared by the sol–gel method, pre-heat treated and then re-dispersed in the mixture of H2O and ethanol. The weight of deposited silica films was maximized when 0.2 mass % of PAA against the whole amount of sol was added. The particles constructing the thick silica films were packed densely when the amount of added PAA was less than 0.2 mass%. The weight of the film increased with decrease in the content of H2O in the sol when a fixed amount of PAA was added. After the heat treatment of deposited films at 800 °C, crack-free silica films of about 30 m thickness were prepared. © 1998 Chapman & Hall     

Soft magnetic properties of NiFeTa thin films for biasing film applications in magnetoresistive elements

The effects of Ta addition on the magnetic properties of permalloy thin films have been investigated. The alloy compositions on a weight basis are (Ni₈₁Fe₁₉)_1-x Ta _x with 0 x 0.105, and the films are sputtered onto a glass substrate at between room temperature and 300 C. The saturation magnetization and anisotropic magnetic field decrease with increasing Ta content. The saturation magnetization is 0.75 T at 5 wt % Ta. The coercivity remains constant at 125 Am^-1. The electrical resistivity increases linearly with increasing Ta content, then saturates at approximately 7.5 wt% Ta. The saturation resistivity is approximately 1.00 m. The magnetoresistivity ratio (/) decreases with increasing Ta content, mainly due to increased electrical resistivity (). The magnetostriction changes from negative to positive with increasing Ta content and reaches nearly zero at 2 wt% Ta. The NiFeTa films containing 5–6 wt% Ta have potential for use as the soft-biasing film in magnetoresistive elements.     

Two-step design of critical control systems using disturbance cancellation integral controllers

An efficient critical control system design is proposed in this paper. The key idea is to decompose the design problem into two simpler design steps by the technique used in the classical loop transfer recovery method (LTR). The disturbance cancellation integral controller is used as a basic controller. Since the standard loop transfer recovery method cannot be applied to the disturbance cancellation controller, the nonstandard version recently found is used for the decomposition. Exogenous inputs with constraints both on the amplitude and rate of change are considered. The majorant approach is taken to obtain the analytical sufficient matching conditions. A numerical design example is presented to illustrate the effectiveness of the proposed design.     

Discharge properties and chemical stability of SrZrO films

Abstract— MgO thin film is currently used as a surface protective layer for dielectric materials because MgO has a high resistance during ion sputtering and exhibits effective secondary electron emission. The secondary‐electron‐emission coefficient γ of MgO is high for Ne ions; however, it is low for Xe ions. The Xe content of the discharge gas of PDPs needs to be raised in order to increase the luminous efficiency. Thus, the development of high‐γ materials replacing MgO is required. The discharge properties and chemical surface stability of SrO containing Zr (SrZrO) as the candidate high‐γ protective layer for noble PDPs have been characterized. SrZrO films have superior chemical stability, especially the resistance to carbonation because of the existence of a few adsorption sites due to their amorphous structure. The firing voltage is 60 V lower than that of MgO films for a discharge gas of Ne/Xe = 85/15 at 60 kPa.