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51.
Kurokawa M Masuda Y Noda M Usuda M Takeda S Hasegawa M Homma Y Sugano M 《Journal of oleo science》2008,57(1):35-45
In a placebo-controlled double-blind study, we examined the effects of dressing containing plant sterol (PS) on blood lipids and the safety in Japanese borderline or mildly hypercholesterolemic subjects. Fifty-nine subjects [total cholesterol (TC) concentration > or = 200 mg/dL] were randomly divided into two groups and were given daily 15 g of dressing containing 800 mg of PS [PS(+)-group] or without PS [PS(-)-group] for 12 weeks. Every 4 weeks, fasting blood was examined and subjective symptoms were analyzed. Serum TC, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) concentrations did not change in the PS(-)-group, while TC and ApoB significantly decreased in the PS(+)-group at 8 and 12 weeks and LDL-C at 4, 8 and 12 weeks. Moreover, serum TC, LDL-C and ApoB concentrations were significantly lower than those of PS(-)-group at 8 and 12 weeks. Other laboratory tests were all in normal ranges and no adverse events were observed. The results indicated that PS-containing dressing decreased serum TC, LDL-C and ApoB concentrations in borderline or mildly hypercholesterolemic subjects. It is therefore proved that the dressing containing PS is helpful in maintaining blood cholesterol level normal and hence, the health of Japanese. 相似文献
52.
Polyacene capacitors 总被引:2,自引:0,他引:2
Shizukuni Yata Eiji Okamoto Hisashi Satake Hidekazu Kubota Masanori Fujii Tomohiro Taguchi Hajime Kinoshita 《Journal of power sources》1996,60(2):207-212
We fabricated two types of polyacene capacitor with extremely stable polyacenic semiconductor (PAS) as the positive and negative electrodes. The first one is a coin-type PAS capacitor (six different sizes), which possesses large capacity with high reliability. Its capacity is much larger than that of the conventional electric double-layer capacitor which uses activated carbon as electrode. PAS capacitor can maintain more than 70% of the initial capacity even after 100 000 cycles. Moreover, this capacitor can be charged and discharged in a few minutes as well as at low rate. The second one is a cylinder-type PAS capacitor (diameter: 18 mm, height: 65 mm) which shows high capacity of 100 F and can discharge at the extremely high rate of 80 C. The coin-type PAS capacitor is currently used for memory back-up of electrical and communication equipment, and the cylinder-type is considered to be useful as power back-up for starting drive parts of electric equipment which needs high power density. 相似文献
53.
Rejina Shrestha Naoko Murata-Kamiya Satoshi Imai Masami Yamamoto Tetsuya Tsukamoto Sachiyo Nomura Masanori Hatakeyama 《International journal of molecular sciences》2022,23(5)
The initial step in bacterial infection is adherence of the bacterium to the target cell surface. Helicobacter pylori exploits the interaction of bacterial adhesin protein HopQ with human epithelial CEACAMs (CEACAM1, 5, and 6) to stably adhere to gastric epithelial cells, which is necessary for delivery of the H. pylori CagA oncoprotein into the epithelial cells via a type IV secretion system. In contrast to human CEACAMs, however, HopQ does not interact with Ceacam1 (mouse CEACAM1) in vitro or in CHO cells ectopically expressing Ceacam1. Since the mouse genome lacks Ceacam5 and Ceacam6, no significant HopQ–Ceacam interaction may occur in mouse gastric epithelial cells. Here, we found that the mouse stomach has a much lower expression level of Ceacam1 than the expression level of CEACAM1 in the human stomach. Consistently, mouse gastric epithelial cells resist CagA delivery by cagA-positive H. pylori, and the delivery is restored by ectopic expression of human CEACAM1 or CEACAM5 in mouse gastric epithelial cells. Thus, despite the fact that mice are routinely used for H. pylori infection studies, a low expression level of Ceacam1 in the mouse stomach together with the loss or greatly reduced interaction of HopQ with Ceacams make the mouse an inappropriate model for studying the role of H. pylori-delivered CagA in gastric pathogenesis, including the development of gastric cancer. 相似文献
54.
55.
Wenxi Tian Yuki Ishiwatari Satoshi Ikejiri Masanori Yamakawa Yoshiaki Oka 《Nuclear Engineering and Design》2009,239(11):2382-2390
In present study, the collapse of void bubble in liquid has been simulated using moving particle semi-implicit (MPS) code. The liquid is described using moving particles and the bubble–liquid interface was set to be vacuum pressure boundary without interfacial heat mass transfer. The topological shape of bubble can be traced according to the motion and location of interfacial particles. The time dependent bubble diameter, interfacial velocity and bubble collapse time were obtained under wide parametric range. The comparison with Rayleigh and Zababakhin's prediction showed a good agreement which validates the applicability and accuracy on MPS method in solving present momentum problems. The potential void induced water hammer pressure pulse was also evaluated which is instructive for further material erosion study. The bubble collapse with non-condensable gas has been further simulated and the rebound phenomenon was successfully captured which is similar with vapor-filled cavitation phenomenon. The present study exhibits some fundamental characteristics of void bubble hydrodynamics and it is also expected to be instructive for further applications of MPS method to complicated bubble dynamics problems. 相似文献
56.
Effects of incorporation of ionic groups and ionic interactions to a model polypeptide, poly(γ-benzyl-L-glutamate) (PBLG), are studied. Partial conversion of γ-benzyl-L-glutamate residues to glutamic acid residues does not change molecular conformation (α-helix) and shows little change in properties. By contrast, partial conversion to sodium glutamates (ionic groups) leads to conversion from a rigid rod to a semi-flexible rod at low ion contents and causes significant changes in thermal stability and birefringence. In solution, lyotropic liquid crystalline behavior of PBLG is lost at ion content as low as 3.2 mol %. In solid, birefringence is still observed at this ion content, suggesting thermotropic liquid crystallinity of this ionic PBLG. Molecular composites made of ionic PBLG as a reinforcer and poly(4-vinylpyridine) (PVP) as a matrix polymer show significant enhancement in strength and toughness as a result of ion-dipole interactions between the component polymers. 相似文献
57.
Keiichi Miyamoto Ayaka Kawasaki Yuko Nagata Masanori Uraya Hisayoshi Kojima Takanori Ito Takashi Horiuchi Nagisa Asakawa Shinsuke Nomura 《Materials science & engineering. C, Materials for biological applications》2011,31(2):158-165
Immunoglobulin A1 (IgA1) concentration in the plasma of patients with IgA nephropathy (IgAN) as the cause of renal failure is higher than that in the plasma of normal controls. IgA1 with abnormal sugars is considered to deposit in the glomerular mesangium, aggravating nephritis in IgAN. Jacalin is a lectin that recognizes sugars on IgA1. However, its selective-recognition for normal-type (ST type, NeuAc-α(2,3)-Gal-β(1,3)-GalNAc) and abnormal-type (T type, Gal-β(1,3)-GalNAc; Tn type, GalNAc; STn type, NeuAc-α(2,6)-GalNAc) sugars α-O-linked to serine/threonine in IgA1 is weak. Therefore, jacalin cannot be used for recognizing specific sugar types on IgA1. We attempted to develop a new recognition method for specific sugar types on IgA1 by utilizing the multirecognition capability of jacalin. Its binding abilities were regulated by heat denaturation with suitable template sugar (galactose or N-acetylgalactosamine). Further, we successfully prepared denatured-jacalin derivatives, which recognized ST-/T-type sugars on IgA1, by sugar-immobilized affinity chromatography. Enzyme-linked immunosorbent assay of denatured-jacalin derivatives, showed the ratios of abnormal sugars on IgA1 in the plasma of IgAN patients and normal controls to be approximately 60% and 20%, respectively. The results proved that profiling of sugar types in IgAN can successfully be performed by solely using jacalin derivatives. 相似文献
58.
Satoshi Akamaru Masanori Hara Norio Nunomura Masao Matsuyama 《International Journal of Hydrogen Energy》2013
The magnetic susceptibility and the pressure-composition isotherm were measured simultaneously for Pd–Rh–H and Pd–Ag–H systems in order to clarify the effect of Rh or Ag substitution on the hydrogen uptake from viewpoint of the electronic band structure. The magnetic susceptibility of all Pd binary alloys prepared decreased monotonically with increasing hydrogen content. At high hydrogen contents, the magnetic susceptibility became approximately zero for Pd–Rh–H and Pd–Ag–H system, and the hydrogen content at which the magnetic susceptibility gives zero corresponded with the terminal of the plateau region in the isotherm curve. The results indicated that the magnetic susceptibility of hydride phase was almost zero for all Pd binary alloys. On the basis of the band structure of Pd metal, we concluded that atom substitution only affected shift of the energy at Fermi level, and the amount of the hydrogen uptake was dominated by the number of unoccupied d-band in the alloys. 相似文献
59.
Masanori Yoshida Akira Ito Kazuaki Yamagiwa Akira Ohkawa Masahiko Abe Shuichi Tezura Masuo Shimazaki 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2001,76(4):383-392
Power characteristics of an unbaffled aerated agitated vessel with unsteadily forward‐reverse rotating impellers, ie a new type of gas–liquid agitator named ‘AJITER’, treating viscous Newtonian liquids were studied experimentally. Measurements were first made on the agitation torque, ie the torque on the drive shaft on which forward–reverse rotating impellers with four delta‐type blades were attached, and the data obtained were analyzed by fitting them to an equation consisting of two terms with respect to the resistance of the fluid, one due to viscous drag and the other due to added moment of inertia. The effects of operating conditions and physical properties of liquids on the drag and added moment of inertia coefficients were then evaluated, and empirical relationships which estimate values of these coefficients, useful to predict the unsteady behavior and magnitude of agitation torque, were presented. Furthermore, equations were developed for estimating the average and maximum power consumptions as a function of the drag and added moment of inertia coefficients. Prediction of respective power levels in AJITER by these equations was also discussed. © 2001 Society of Chemical Industry 相似文献
60.
Atomic resolution high voltage electron microscopy was applied in investigations of the atomic structure of [112] sigma3 CSL grain boundary of silicon. Images of the grain boundary, viewed in the < 110 > direction, showed two types of dark spots. One type was rod shaped, which represented an atomic pair aligned in the < 111 > direction. The other was a small round spot, which represented a single atomic column in the grain boundary. The atomic structure of [112] sigma3 CSL grain boundary was directly shown from the atomic-structure image. 相似文献