Gangliosides in Podocyte Biology and Disease

Gangliosides constitute a subgroup of glycosphingolipids characterized by the presence of sialic acid residues in their structure. As constituents of cellular membranes, in particular of raft microdomains, they exert multiple functions, some of them capital in cell homeostasis. Their presence in cells is tightly regulated by a balanced expression and function of the enzymes responsible for their biosynthesis, ganglioside synthases, and their degradation, glycosidases. The dysregulation of their abundance results in rare and common diseases. In this review, we make a point on the relevance of gangliosides and some of their metabolic precursors, such as ceramides, in the function of podocytes, the main cellular component of the glomerular filtration barrier, as well as their implications in podocytopathies. The results presented in this review suggest the pertinence of clinical lipidomic studies targeting these metabolites.     

Isoprene rubber filled with silica generated in situ

We modified synthetic isoprene rubber by means of the in situ generation of silica particles through the sol–gel process starting from tetraethoxysilane (TEOS) as an inorganic oxide precursor. Different reaction conditions were investigated with variations in the initial TEOS content, the reaction time of the sol–gel process, and the presence of a coupling/surfactant agent (octyltriethoxysilane). Organic–inorganic hybrid materials with a silica content up to 70 phr were obtained with the complete conversion of TEOS to silica for a long enough sol–gel reaction time. A very homogeneous dispersion of silica particles was observed in all cases together with a very good adhesion between the filler and matrix. The size of the in situ generated silica was controlled by the appropriate addition of octyltriethoxysilane. Swelling and extraction tests and dynamic mechanical analysis indicated that the vulcanization process of isoprene rubber was perturbed by the sol–gel process; this led to a slight decrease in the crosslinking degree. However, a significant reinforcing effect due to the presence of silica particles was observed for all of the investigated samples. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011     

Active/passive control of sound radiation and power flow in fluid-loaded shells

The vibration and noise radiation from fluid-loaded cylindrical shells are controlled by using multiple stiffeners and passive constrained layer damping treatment. Dynamic and fluid finite elements are developed to study the fundamental phenomena governing the coupling between the stiffened shell, with and without damping, and the fluid domain surrounding it. The models are used to predict the response of the shell and to evaluate the effect of stiffening rings and damping treatment on both the structural vibration and noise radiation in the fluid domain. The geometry of the shell and fluid domain allows the formulation of a harmonic-based model, which uncouples the fluid–structural response of modes corresponding to different numbers of circumferential nodes.In this study, it is shown that stiffening of the shell reduces the amplitude of the vibration and noise radiation, particularly for high-order lobar modes. The attenuation of the shell response and sound radiation can be increased significantly through the application of passive constrained layer damping treatments on the inner surface of the stiffening rings.     

A global approach to the physics validation of simulation codes for future nuclear systems

This paper presents a global approach to the validation of the parameters that enter into the neutronics simulation tools for advanced fast reactors with the objective to reduce the uncertainties associated to crucial design parameters. This global approach makes use of sensitivity/uncertainty methods; statistical data adjustments; integral experiment selection, analysis and “representativity” quantification with respect to a reference system; scientifically based cross-section covariance data and appropriate methods for their use in multigroup calculations. This global approach has been applied to the uncertainty reduction on the criticality of the Advanced Burner Reactor (both metal and oxide core versions) presently investigated in the frame of the GNEP initiative. The results obtained are very encouraging and allow to indicate some possible improvements of the ENDF/B-VII data file.     

东营三角洲演化特征与岩性圈闭分布规律

东营三角洲是东营凹陷古近系沙河街组沙三段的主要沉积体系之一，为一大型复合三角洲。该三角洲形成的浊积砂体岩性圈闭是东营凹陷沙三段重要的勘探目标，近几年平均每年发现的岩性油藏石油储量超过千万吨。为了给东营三角洲隐蔽油气藏进一步的勘探提供科学依据，运用高分辨率层序地层学理论和分析方法，在建立高频层序地层格架的基础上，研究东营三角洲演化过程、古构造坡折发育类型及不同期次三角洲与构造坡折的配置关系，分析这些因素对岩性圈闭形成的重要作用，认为在进积时期推进距离较远(三角洲进积作用大于加积作用)、退积时期湖泛规模较大条件下发育的三角洲朵叶体易形成具有一定规模的浊积扇．     

An automatic procedure for the synthesis and optimization of very low-frequency Gm–C integrators

Fully integrated low frequency filters are critical cells that should be carefully designed in order to avoid excessive area occupation. In this work we propose an automatic procedure capable of optimizing the design of G_m?CC integrators, which constitute the basis of a wide class of G_m?CC filters. The optimization target is minimizing the cell area with constraints on input range and low frequency noise. Lower and upper bounds can be fixed to most quantities and design parameters in order to avoid solutions that are not compatible with the physical limitations of the process. The program has been developed within the MATLAB^? platform, exploiting the optimization toolbox. The effect of several important design parameters on the optimization of low frequency integrators has been investigated using the proposed routine. The strong interaction between noise and low frequency constraints has been demonstrated, showing the impressive impact of strict noise specifications on the occupied area. The actual effectiveness of parameters such as the current division factor or approaches such as flicker noise rejection by means of chopper modulation has been investigated. Examples of integrator synthesis, performed using the proposed procedure configured with the parameters of a commercial CMOS process, are presented. The consistence between the characteristics of the cells and the initial specifications has been checked using electrical simulations showing a maximum discrepancy with the initial specifications of nearly 80%. A semi-manual method to refine the synthesized cells and improve the accuracy is proposed.