全文获取类型
收费全文 | 259篇 |
免费 | 18篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 2篇 |
化学工业 | 159篇 |
金属工艺 | 6篇 |
机械仪表 | 4篇 |
建筑科学 | 3篇 |
能源动力 | 3篇 |
轻工业 | 9篇 |
石油天然气 | 2篇 |
无线电 | 22篇 |
一般工业技术 | 39篇 |
冶金工业 | 7篇 |
自动化技术 | 22篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 54篇 |
2021年 | 59篇 |
2020年 | 11篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2017年 | 14篇 |
2016年 | 12篇 |
2015年 | 17篇 |
2014年 | 13篇 |
2013年 | 15篇 |
2012年 | 9篇 |
2011年 | 18篇 |
2010年 | 2篇 |
2009年 | 4篇 |
2008年 | 3篇 |
2007年 | 5篇 |
2006年 | 2篇 |
2005年 | 3篇 |
2004年 | 1篇 |
1998年 | 1篇 |
1986年 | 1篇 |
排序方式: 共有278条查询结果,搜索用时 15 毫秒
71.
Karolina Stachyra Monika Dudzisz-
led
Elbieta Bylina Anna Szumera-Ciekiewicz Mateusz J. Spaek Ewa Bartnik Piotr Rutkowski Anna M. Czarnecka 《International journal of molecular sciences》2021,22(12)
Merkel cell carcinoma (MCC) is an uncommon and highly aggressive skin cancer. It develops mostly within chronically sun-exposed areas of the skin. MCPyV is detected in 60–80% of MCC cases as integrated within the genome and is considered a major risk factor for MCC. Viral negative MCCs have a high mutation burden with a UV damage signature. Aberrations occur in RB1, TP53, and NOTCH genes as well as in the PI3K-AKT-mTOR pathway. MCC is highly immunogenic, but MCC cells are known to evade the host’s immune response. Despite the characteristic immunohistological profile of MCC, the diagnosis is challenging, and it should be confirmed by an experienced pathologist. Sentinel lymph node biopsy is considered the most reliable staging tool to identify subclinical nodal disease. Subclinical node metastases are present in about 30–50% of patients with primary MCC. The basis of MCC treatment is surgical excision. MCC is highly radiosensitive. It becomes chemoresistant within a few months. MCC is prone to recurrence. The outcomes in patients with metastatic disease are poor, with a historical 5-year survival of 13.5%. The median progression-free survival is 3–5 months, and the median overall survival is ten months. Currently, immunotherapy has become a standard of care first-line therapy for advanced MCC. 相似文献
72.
73.
Jing Hou Zihan Song Mateusz Odziomek Nadezda V. Tarakina 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(41):2301415
Carbonaceous materials are promising sodium-ion battery anodes. Improving their performance requires a detailed understanding of the ion transport in these materials, some important aspects of which are still under debate. In this work, nitrogen-doped porous hollow carbon spheres (N-PHCSs) are employed as a model system for operando analysis of sodium storage behavior in a commercial liquid electrolyte at the nanoscale. By combining the ex situ characterization at different states of charge with operando transmission electron microscopy experiments, it is found that a solvated ionic layer forms on the surface of N-PHCSs at the beginning of sodiation, followed by the irreversible shell expansion due to the solid-electrolyte interphase (SEI) formation and subsequent storage of Na(0) within the porous carbon shell. This shows that binding between Na(0) and C creates a Schottky junction making Na deposition inside the spheres more energetically favorable at low current densities. During sodiation, the SEI fills the gap between N-PHCSs, binding spheres together and facilitating the sodium ions' transport toward the current collector and subsequent plating underneath the electrode. The N-PHCSs layer acts as a protective layer between the electrolyte and the current collector, suppressing the possible growth of dendrites at the anode. 相似文献
74.
Functionalized Graphdiyne Nanowires: On‐Surface Synthesis and Assessment of Band Structure,Flexibility, and Information Storage Potential
下载免费PDF全文
![点击此处可从《Small (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Florian Klappenberger Raphael Hellwig Ping Du Tobias Paintner Martin Uphoff Liding Zhang Tao Lin Bahare Abedin Moghanaki Mateusz Paszkiewicz Ivana Vobornik Jun Fujii Olaf Fuhr Yi‐Qi Zhang Francesco Allegretti Mario Ruben Johannes V. Barth 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(14)
Carbon nanomaterials exhibit extraordinary mechanical and electronic properties desirable for future technologies. Beyond the popular sp2‐scaffolds, there is growing interest in their graphdiyne‐related counterparts incorporating both sp2 and sp bonding in a regular scheme. Herein, we introduce carbonitrile‐functionalized graphdiyne nanowires, as a novel conjugated, one‐dimensional (1D) carbon nanomaterial systematically combining the virtues of covalent coupling and supramolecular concepts that are fabricated by on‐surface synthesis. Specifically, a terphenylene backbone is extended with reactive terminal alkyne and polar carbonitrile (CN) moieties providing the required functionalities. It is demonstrated that the CN functionalization enables highly selective alkyne homocoupling forming polymer strands and gives rise to mutual lateral attraction entailing room‐temperature stable double‐stranded assemblies. By exploiting the templating effect of the vicinal Ag(455) surface, 40 nm long semiconducting nanowires are obtained and the first experimental assessment of their electronic band structure is achieved by angle‐resolved photoemission spectroscopy indicating an effective mass below 0.1m0 for the top of the highest occupied band. Via molecular manipulation it is showcased that the novel oligomer exhibits extreme mechanical flexibility and opens unexplored ways of information encoding in clearly distinguishable CN‐phenyl trans–cis species. Thus, conformational data storage with density of 0.36 bit nm?2 and temperature stability beyond 150 K comes in reach. 相似文献
75.
ukasz Boguszewicz Agata Biele Mateusz Ciszek Jacek Wendykier Krzysztof Szczepanik Agnieszka Skorupa Jolanta Mrochem-Kwarciak Krzysztof Skadowski Maria Sok 《International journal of molecular sciences》2021,22(12)
In the present study, we analyze the nuclear magnetic resonance (NMR) blood serum metabolic profiles of 106 head and neck squamous cell carcinoma (HNSCC) patients during radio (RT) and concurrent radio-chemotherapy (CHRT). Four different fractionation schemes were compared. The blood samples were collected weekly, from the day before the treatment until the last week of CHRT/RT. The NMR spectra were acquired on A Bruker 400 MHz spectrometer at 310 K and analyzed using multivariate methods. Seven metabolites were found significantly to be altered solely by radiotherapy: N-acetyl-glycoprotein (NAG), N-acetylcysteine, glycerol, glycolate and the lipids at 0.9, 1.3 and 3.2 ppm. The NMR results were correlated with the tissue volumes receiving a particular dose of radiation. The influence of the irradiated volume on the metabolic profile is weak and mainly limited to sparse correlations with the inflammatory markers, creatinine and the lymphocyte count in RT and the branched-chain amino-acids in CHRT. This is probably due to the optimal planning and delivery of radiotherapy improving sparing of the surrounding normal tissues and minimizing the differences between the patients (caused by the tumor location and size). 相似文献
76.
Sylwia Belica-Pacha Mateusz Dako Vyacheslav Buko Ilya Zavodnik Katarzyna Miowska Maria Bryszewska 《International journal of molecular sciences》2021,22(22)
The interaction between sertraline hydrochloride (SRT) and randomly methylated β-cyclodextrin (RMβCD) molecules have been investigated at 298.15 K under atmospheric pressure. The method used—Isothermal Titration Calorimetry (ITC) enabled to determine values of the thermodynamic functions like the enthalpy (ΔH), the entropy (ΔS) and the Gibbs free energy (ΔG) of binding for the examined system. Moreover, the stoichiometry coefficient of binding (n) and binding/association constant (K) value have been calculated from the experimental results. The obtained outcome was compared with the data from the literature for other non-ionic βCD derivatives interacting with SRT and the enthalpy-entropy compensation were observed and interpreted. Furthermore, the connection of RMβCD with SRT was characterized by circular dichroism spectroscopy (CD) and complexes of βCD derivatives with SRT were characterized through the computational studies with the use of molecular docking (MD). 相似文献
77.
Mateusz Barczewski Olga Mysiukiewicz Jacek Andrzejewski Danuta Matykiewicz Dominik Medycki Arkadiusz Kloziński Katarzyna Skórczewska Marek Szostak 《Polymer Engineering and Science》2020,60(7):1588-1603
The study investigates the thermo-mechanical properties of isotactic polypropylene (iPP) hybrid composites in reference to various amounts of particle- and fiber-shaped inorganic fillers. Three grades of hybrid composites were prepared as a function of filler amount: 5, 10, and 20 wt% and different ratios of glass fiber (GF) and calcium carbonate (CaCO3). The main objective is to describe the relationship between the hybridization efficiency and mechanical performance of polypropylene-based composites. The analysis of the thermo-mechanical properties of the composites shows that both the total amount of the filler and the ratio of GF and CaCO3 clearly influence the properties of the composites. Hybrid composites with the highest amount of the GF display improved thermo-mechanical stability. The presence of well-dispersed CaCO3 in the composites was found to improve elongation at break and Vicat softening temperature values. Even though it is glass fiber, which shows higher filler effectiveness and visibly reinforces the composite samples, causing an increase in tensile strength or reinforcing efficiency, replacing up to 50% of this filler with calcium carbonate does not result in a considerable deterioration of the properties of the material. 相似文献
78.
Mateusz Kciuk Adrianna Gieleciska Adrianna Budzinska Mariusz Mojzych Renata Kontek 《International journal of molecular sciences》2022,23(7)
Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider the molecular basis of metastasis. The aim of this work is to provide a comprehensive review focusing on cancer metastasis and the mitogen-activated protein kinase (MAPK) pathway (ERK/JNK/P38 signaling) as a crucial modulator of this process. 相似文献
79.
Anna Kusienicka Karolina Bukowska-Strakova Maciej Ciela Witold Norbert Nowak Iwona Bronisz-Budzyska Agnieszka Seretny Monika ukowska Mateusz Je Rocisaw Krutyhoowa Hevidar Taha Neli Kachamakova-Trojanowska Halina Wa Claudine Kieda Alicja Jzkowicz 《International journal of molecular sciences》2022,23(7)
Melanoma-initiating cells (MICs) contribute to the tumorigenicity and heterogeneity of melanoma. MICs are identified by surface and functional markers and have been shown to display cancer stem cell (CSC) properties. However, the existence of MICs that follow the hierarchical CSC model has been questioned by studies showing that single unselected melanoma cells are highly tumorigenic in xenotransplantation assays. Herein, we characterize cells expressing MIC markers (CD20, CD24, CD133, Sca-1, ABCB1, ABCB5, ALDHhigh) in the B16-F10 murine melanoma cell line. We use flow cytometric phenotyping, single-cell sorting followed by in vitro clonogenic assays, and syngeneic in vivo serial transplantation assays to demonstrate that the expression of MIC markers does not select CSC-like cells in this cell line. Previously, our group showed that heme-degrading enzyme heme oxygenase-1 (HO-1) can be upregulated in melanoma and increase its aggressiveness. Here, we show that HO-1 activity is important for non-adherent growth of melanoma and HO-1 overexpression enhances the vasculogenic mimicry potential, which can be considered protumorigenic activity. However, HO-1 overexpression decreases clone formation in vitro and serial tumor initiation in vivo. Thus, HO-1 plays a dual role in melanoma, improving the progression of growing tumors but reducing the risk of melanoma initiation. 相似文献
80.