基于无线网络的制造业物料配送系统的设计*

针对制造业传统物料配送系统存在的缺点,基于业务流程再造的理念,运用无线局域网技术设计了全新的物料配送系统。该系统能够对配送流程进行优化,提高了配送效率,有效地解决了配送不及时所造成的生产速度瓶颈问题。     

Ensemble deep transfer learning driven by multisensor signals for the fault diagnosis of bevel-gear cross-operation conditions

The existing intelligent fault diagnosis techniques of bevel gear focus on single-sensor signal analysis under the steady operation condition. In this study, a new method is proposed based on ensemble deep transfer learning and multisensor signals to enhance the fault diagnosis adaptability and reliability of bevel gear under various operation conditions. First, a novel stacked autoencoder(NSAE) is constructed using a denoising autoencoder, batch normalization, and the Swish activation function. Second, a series of source-domain NSAEs with multisensor vibration signals is pretrained. Third, the good model parameters provided by the source-domain NSAEs are transferred to initialize the corresponding target-domain NSAEs. Finally, a modified voting fusion strategy is designed to obtain a comprehensive result. The multisensor signals collected under the different operation conditions of bevel gear are used to verify the proposed method. The comparison results show that the proposed method can diagnose different faults in an accurate and stable manner using only one target-domain sample, thereby outperforming the existing methods.     

HFSS仿真在微波技术课程教学中的应用

为提升微波技术课程质量与教学效果,激发学员学习兴趣,提出将HFSS仿真应用于微波技术课程教学.首先对课程教学进行了分析;然后给出了HFSS仿真在课程教学中的应用方法;最后运用课堂中列举仿真实例方式,给出微波网络知识点教学的实施,并对其教学效果进行反馈调查.教学案例表明,HFSS仿真在微波技术课程教学中的应用提高了学员学习兴趣,加深了对知识的理解,从而有助于教员更好地教与学员更好地学.     

Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA

Reactive intermediate deaminase (Rid) proteins are enzymes conserved in all domains of life. UK114, a mammalian member of RidA subfamily, has been firstly identified as a component of liver perchloric acid-soluble proteins (L-PSP). Although still poorly defined, several functions have been attributed to the mammalian protein UK114/RIDA, including the reactive intermediate deamination activity. The expression of UK114/RIDA has been observed in some tumors, arousing interest in this protein as an evaluable tumor marker. However, other studies reported a negative correlation between UK114/RIDA expression, tumor differentiation degree and cell proliferation. This work addressed the question of UK114/RIDA expression in human non-tumor HEK293 cell lines and in some human tumor cell lines. Here we reported that human RIDA (hRIDA) was expressed in all the analyzed cell line and subjected to lysine (K-)succinylation. In HEK293, hRIDA K-succinylation was negatively correlated to the cell proliferation rate and was under the control of SIRT5. Moreover, K-succinylation clearly altered hRIDA quantification by immunoblotting, explaining, at least in part, some discrepancies about RIDA expression reported in previous studies. We found that hRIDA was able to deaminate reactive enamine-imine intermediates and that K-succinylation drastically reduced deaminase activity. As predicted by in silico analysis, the observed reduction of deaminase activity has been related to the drastic alterations of hRIDA structure inferred by K-succinylation. The role of hRIDA and the importance of its K-succinylation in cell metabolism, especially in cancer biology, have been discussed.     

High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures

The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer’s disease (AD), flaws of the cerebral glucose uptake translate into reduced protein O-GlcNAcylation, which promote the formation of pathological hallmarks. A high-fat diet (HFD) is known to foster metabolic dysregulation and insulin resistance in the brain and such effects have been associated with the reduction of cognitive performances. Remarkably, a significant role in HFD-related cognitive decline might be played by aberrant protein O-GlcNAcylation by triggering the development of AD signature and mitochondrial impairment. Our data support the impairment of total protein O-GlcNAcylation profile both in the brain of mice subjected to a 6-week high-fat-diet (HFD) and in our in vitro transposition on SH-SY5Y cells. The reduction of protein O-GlcNAcylation was associated with the development of insulin resistance, induced by overfeeding (i.e., defective insulin signaling and reduced mitochondrial activity), which promoted the dysregulation of the hexosamine biosynthetic pathway (HBP) flux, through the AMPK-driven reduction of GFAT1 activation. Further, we observed that a HFD induced the selective impairment of O-GlcNAcylated-tau and of O-GlcNAcylated-Complex I subunit NDUFB8, thus resulting in tau toxicity and reduced respiratory chain functionality respectively, highlighting the involvement of this posttranslational modification in the neurodegenerative process.     

Sintered stainless steels: Fatigue crack propagation resistance under hydrogen charging conditions

Monophasic and multiphasic (two and three phases) sintered stainless steels were prepared both considering premixes of AISI 316LHC and AISI 434LHC stainless steels powders and using a prealloyed duplex stainless steel 25% Cr, 5% Ni, 2% Mo powder. Their fatigue crack propagation resistance was investigated both in air and under hydrogen charging conditions (0.5 M H₂SO₄ + 0.01 M KSCN aqueous solution; applied potential = −700 mV/SCE), considering three different stress ratios (R = 0.1; 0.5; 0.75). Fatigue crack propagation micromechanisms were investigated by means of fracture surface scanning electron microscope (SEM) analysis.For all the investigated sintered stainless, fatigue crack propagation resistance is influenced by hydrogen charging and an increase of crack growth rates dependent on the steel microstructure is obtained. Experimental results also allow to identify the sintered stainless steel obtained from the prealloyed 25% Cr, 5% Ni, 2% Mo powder as the most resistant to fatigue crack propagation in air and under hydrogen charging conditions.     

试论大型汽车覆盖件模具制造调试的途径

针对汽车大型覆盖件零件的工艺特点，采用先进的模拟仿真技术、测量技术、调试技术、逆向工程技术，探索出了一条汽车大型覆盖件模具制造调试的途径。     

我国型钢生产技术进步20年及展望

按小型材、棒线材、中型材、轨梁和大型材分类 ,对 2 0年来我国在型钢生产领域的主要技术进步进行了总结 ,对其生产现状进行了分析 ,对其发展前景进行了展望     

Effects of Austempering after Hot Deformation on the Mechanical Properties of Hot Rolled Si-Mn TRIP Steel Sheets

Excellent mechanical properties are obtained by austempering after hot deformation without subsequent heat treatment in the present Si-Mn TRIP steel sheets. Isothermal holding time after finishing rolling has affected the mechanical properties of this steel. The results show that the sample exhibits a good combination of ultimate tensile strength and total elongation when it is held at the bainite transformation temperature after hot deformation. The stability of retained austenite increases with an increase of isothermal holding time, and a further increase in the holding duration results in a decrease of it. The tensile strength, total elongation and strength ductility reach the maximum values (774MPa, 33% and 25542MPa% respectively) for this sort of hot rolled Si-Mn TRIP steel using the optimal technology.