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排序方式: 共有156条查询结果,搜索用时 15 毫秒
71.
Christian Schrader Jürgen Schmidt Michael Diefenbeck Thomas Mückley Sergiy Zankovych Jörg Bossert Klaus D. Jandt Mathilde Faucon Ulrich Finger 《Advanced Engineering Materials》2012,14(3):B21-B27
The surface properties of titanium alloy implants for improved osseointegration in orthopaedic and dental surgery have been modified by many technologies. Hydroxyapatite coatings with a facultative integration of growth factors deposited by plasma spraying showed improved osseointegration. Our approach in order to enhance osseointegration was carried out by a surface modification method of titanium alloy implants called plasma chemical oxidation (PCO). PCO is an electrochemical procedure that converts the nm‐thin natural occurring titanium‐oxide layer on an implant to a 5 µm thick ceramic coating (TiOB‐surface). Bioactive TiOB‐surfaces have a porous microstructure and were loaded with calcium and phosphorous, while bioinert TiOB‐surfaces with less calcium and phosphorous loadings are smooth. A rat tibial model with bilateral placement of titanium alloy implants was employed to analyze the bone response to TiOB‐surfaces in vivo. 64 rats were randomly assigned to four groups of implants: (i) pure titanium alloy (control), ii) titanium alloy, type III anodization, (iii) bioinert TiOB‐surface, and (iv) bioactive TiOB‐surface. Mechanical fixation was evaluated by pull out tests at 3 and 8 weeks. The bioactive TiOB‐surface showed significantly increased shear strength at 8 weeks compared to all other groups. 相似文献
72.
Didier M Leone L Greneche JM Giffaut E Charlet L 《Environmental science & technology》2012,46(6):3574-3579
In order to assess the adsorption properties of hydrogen gas and reactivity of adsorbed hydrogen, we measured H(2)(g) adsorption on Na synthetic montmorillonite-type clays and Callovo-Oxfordian (COx) clayrock using gas chromatography. Synthetic montmorillonites with increasing structural Fe(III) substitution (0 wt %, 3.2 wt %, and 6.4 wt % Fe) were used. Fe in the synthetic montmorillonites is principally present as structural Fe(III) ions. We studied the concomitant reduction of structural Fe(III) in the clays using (57)Fe M?ssbauer spectrometry. The COx, which mainly contains smectite/illite and calcite minerals, is also studied together with the pure clay fraction of this clayrock. Experiments were performed with dry clay samples which were reacted with hydrogen gas at 90 and 120 °C for 30 to 45 days at a hydrogen partial pressure close to 0.45 bar. Results indicate that up to 0.11 wt % of hydrogen is adsorbed on the clays at 90 °C under 0.45 bar of relative pressure. (57)Fe M?ssbauer spectrometry shows that up to 6% of the total structural Fe(III) initially present in these synthetic clays is reduced upon adsorption of hydrogen gas. No reduction is observed with the COx sample in the present experimental conditions. 相似文献
73.
The cause of Ménétrier's disease is unknown, although various autoimmune, allergic, and infective causes have been postulated. This case report describes a 37-yr-old man with Ménétrier's disease associated with protein-losing enteropathy and Helicobacter pylori infection. Clinical, endoscopic, histological, and biochemical resolution occurred after treatment of Helicobacter pylori infection. The improvement observed in this case supports an etiological role for H. pylori infection in Ménétrier's disease. 相似文献
74.
Jean -Claude Simon Laurent Bramerie Frédéric Ginovart Vincent Roncin Mathilde Gay Sylvain Feve Elodie le Cren Marie -Laure Chares 《电信纪事》2003,58(11-12):1708-1724
Basic principles of all-optical signal regeneration are presented, and main state-of-art techniques are reviewed. Optical fiber and semiconductor based devices are addressed, and some recently reported 2R and 3R signal regeneration experiments are discussed. 相似文献
75.
Magnetization transfer characteristics in atherosclerotic plaque components assessed by adapted binomial preparation pulses 总被引:1,自引:0,他引:1
Mathilde Pachot-Clouard Françoise Vaufrey Luc Darrasse Jean-François Toussainti 《Magma (New York, N.Y.)》1998,7(1):9-15
Increasing the contrast between atheromatous plaque components is a major issue in cardiovascular MRI research. It would allow
one to identify unstable plaque by differentiating the lipid core associated with vulnerability, from the fibrous cap, considered
as a factor of stability. T2 and diffusion-weighted imaging have already provided satisfying results. Magnetization transfer (MT) between restricted protons
Hr and free-water protons Hf could achieve a different contrast related to collagen and lipoprotein macromolecules present in the fibrous cap and lipid
core, respectively. The purpose of this work was to evaluate in vitro the MT effect produced by adapted T2-selective 1-3-3-1 binomial pulses on isolated samples of atheromatous arteries at 3 T. A method based on simulation was used
in order to improve the MT specificity: it is shown that 50% 1-3-3-1 pulses (the percentage indicating the level of Hr saturation) allow an estimation of T2r, the Hr T2. Using this technique, magnetization transfer was observed for the first time in atherosclerotic plaque components, an effect
more pronounced for the fibrous cap and media than for the lipid core and advantitia. The T2r estimation gave values ranging from 20 to 25 μs for the four samples. This preliminary study provides a basis for establishing
an MT imaging sequence of atheromatous arteries, by using 50% 1-3-3-1 pulses calibrated for saturating protons with a 20 μs
T2. This MT protocol should be further compared to T2 and diffusion-weighted imaging. 相似文献
76.
Allison G. Roy J. Michael Robinson Prannda Sharma Alba Rodriguez-Garcia Mathilde A. Poussin Cheryl Nickerson-Nutter Daniel J. Powell Jr. 《International journal of molecular sciences》2021,22(11)
Folate receptor beta (FRβ) is a folate binding receptor expressed on myeloid lineage hematopoietic cells. FRβ is commonly expressed at high levels on malignant blasts in patients with acute myeloid leukemia (AML), as well as on M2 polarized tumor-associated macrophages (TAMs) in the tumor microenvironment of many solid tumors. Therefore, FRβ is a potential target for both direct and indirect cancer therapy. We demonstrate that FRβ is expressed in both AML cell lines and patient-derived AML samples and that a high-affinity monoclonal antibody against FRβ (m909) has the ability to cause dose- and expression-dependent ADCC against these cells in vitro. Importantly, we find that administration of m909 has a significant impact on tumor growth in a humanized mouse model of AML. Surprisingly, m909 functions in vivo with and without the infusion of human NK cells as mediators of ADCC, suggesting potential involvement of mouse macrophages as effector cells. We also found that TAMs from primary ovarian ascites samples expressed appreciable levels of FRβ and that m909 has the ability to cause ADCC in these samples. These results indicate that the targeting of FRβ using m909 has the potential to limit the outgrowth of AML in vitro and in vivo. Additionally, m909 causes cytotoxicity to TAMs in the tumor microenvironment of ovarian cancer warranting further investigation of m909 and its derivatives as therapeutic agents in patients with FRβ-expressing cancers. 相似文献
77.
Mathilde Ouattara-Brigaudet Sandrine Berthon-FabryChristian Beauger Patrick Achard 《International Journal of Hydrogen Energy》2014
The parameters influencing the water management or the gas diffusion have a large impact on the performances of the PEMFC. In this work, we focused on the influence of the composition of the cathode catalytic layer on the performance of the MEA in relation to the relative humidity. A carbon aerogel was synthesized as catalyst support with a texture minimizing diffusive losses. We studied the influence of the Nafion content by preparing various cathode catalytic layers whose hydric properties were modified by adding PTFE as a hydrophobic agent. We evaluated the impact of the cathodic relative humidity by testing MEAs on a single cell test bench. We showed that modifying the composition of the catalytic layers playing on the content of both Nafion and PTFE, enables to improve the performance due to a better water management. The best performance was obtained with a Nafion/Carbon mass ratio (N/C) of 0.5 and a PTFE/Carbon (PTFE/C) mass ratio of 0.35 allowing 40% more power at 0.4 V and 75%RH. A first positive evaluation of the impact of PTFE is also done with TEC10E40E. 相似文献
78.
Julie Pepin Eric Lainé Jean-Claude Grandidier Sylvie Castagnet Pierre Blanc-vannet Philippe Papin Mathilde Weber 《International Journal of Hydrogen Energy》2018,43(33):16386-16399
Depressurization tests at a laboratory scale, coupled with numerical modelling, are used to determine the key parameters responsible for the polymeric liner collapse in hyperbaric type IV hydrogen storage vessels. X-ray tomography allows to determine the damages suffered by the sample during the depressurization step. Results show that the differential pressure induced during the depressurization step between the liner/composite interface and the free surface of the liner is the main factor responsible for the collapse of the liner. For a given temperature, this pressure gradient can be modified by changing the maximum H2 pressure, the emptying rate or by adding a residual pressure plateau. Temperature is also of prime importance by influencing the yield point of the liner, the interface resistance and the amount of gas dissolved into the vessel. Thus, increasing temperature also increases the risk of liner collapse for the same gas exposure conditions. 相似文献
79.
80.
Simon Blotevogel Laurent Steger Daniel Hart Lola Doussang Judit Kaknics Mathilde Poirier Hansjörg Bornhöft Joachim Deubener Cedric Patapy Martin Cyr 《Journal of the American Ceramic Society》2021,104(1):128-139
Ground-granulated blast-furnace slags (GGBS) are glasses (>99%) of the CaO-Al2O3-SiO2 compositional system and are widely used as supplementary cementitious materials. Differences in reactivity of GGBS were screened by modifying the content of 12 minor elements (namely Ba, Ce, Cs, Cr, K, Mn, P, Sn, Sr, Ti, V, and Zr). Scanning electron microscopy observations showed that most elements entered the silicate glass matrix, only Sn was reduced to its metallic form and P accumulated in minor minerals. Mortar strength tests showed that 2 day compressive strength was reduced by >50% for a TiO2 content of 2.5 wt% in the slag. At 28 days the loss in compressive strength was still >40%. Calorimetric tests on other element additions showed that the content of network modifiers (Ba, Cs, K and Sr) and GGBS reactivity are positively correlated, whereas Ce, Cr, V, and Zr significantly decreased reactivity. Finally, it is shown that these effects can be estimated by the concentration and the weighted field strength of the added element. 相似文献