Statistical models that predict the deterioration of sewer pipes are useful for planning financial resources required for sewer renewal. Usually, data that are available to calibrate these models solely concern pipes that are still in place, leading to underestimated deterioration rates. A new method is proposed to consider possible past replacement of pipes in the statistical modeling of their deterioration. The proposed method considers the aging of pipes, simulated with a Cox model, and their probability to be replaced separately. Application to a synthetic sewer network, for which it was assumed that information regarding all pipe replacements over the lifetime of the network was available, showed that the proposed method allows for improved predictions of the sewer deterioration model, when compared to predictions of a model calibrated without considering the information about replaced pipes. 相似文献
Cleavage of the invariant chain is the key event in the trafficking pathway of major histocompatibility complex class II. Cathepsin S is the major processing enzyme of the invariant chain, but cathepsin F acts in macrophages as its functional synergist which is as potent as cathepsin S in invariant chain cleavage. Dedicated low‐molecular‐weight inhibitors for cathepsin F have not yet been developed. An active site mapping with 52 dipeptide nitriles, reacting as covalent–reversible inhibitors, was performed to draw structure–activity relationships for the non‐primed binding region of human cathepsin F. In a stepwise process, new compounds with optimized fragment combinations were designed and synthesized. These dipeptide nitriles were evaluated on human cysteine cathepsins F, B, L, K and S. Compounds 10 (N‐(4‐phenylbenzoyl)‐leucylglycine nitrile) and 12 (N‐(4‐phenylbenzoyl)leucylmethionine nitrile) were found to be potent inhibitors of human cathepsin F, with Ki values <10 nM . With all dipeptide nitriles from our study, a 3D activity landscape was generated to visualize structure–activity relationships for this series of cathepsin F inhibitors. 相似文献
Solvent‐free protocols for Miyaura borylation and the one‐pot, two‐step homocoupling of aryl halides are reported for the first time. Bis(dibenzylideneacetone)palladium(0) [Pd(dba)2] is an optimal source of palladium for Miyaura borylation, while for one‐pot two‐step homocoupling palladium(II) acetate [Pd(OAc)2] gives highest yields. Aryl bromides are coupled most efficiently using the DPEphos ligand. Chlorides are coupled using XPhos. The developed protocols are robust, versatile and easily reproducible on a large scale.
Problems of high-power microwaves penetrating into and reflecting from a semiconductor (silicon) plate with non-stationary
processes are investigated. The plate is the basis of switches activated by laser-driven photoconductivity which changes its
properties when heated by the switched microwave power. Analytical criteria for the stationary solutions of the activated
(quasi-metallic) and deactivated (dielectric) states of the switch under the conditions of high-power microwave heating and
external cooling are found. Results of numerical simulations are also given for the problems of the switch activation by microwave
heating initiated by pulsed laser radiation, which increases the carrier density rapidly. Numerical simulations are carried
out using the finite-difference time-domain method with the unsplit perfectly matched layer absorbing boundary conditions.
We demonstrate various types of solutions depending on the basic parameters of the problems - microwave field intensity, laser
pulse energy and semiconductor doping. 相似文献
We have successfully prepared mono- and bi-functionalized multiwall carbon nanotubes (MWCNT) with thiophene, amine and thiophene-amine groups. The dispersion of nanotubes has been enhanced and stable optimized dispersions in organic solvents were obtained. These functionalized nanotubes have been successfully incorporated into bulk heterojunction (BHJ) organic photovoltaic (OPV) cells with a poly (3-hexyl thiophene) (P3HT) and [6, 6]-phenyl-C(61)-butyric acid methyl ester (PCBM) photoactive blended layer. The incorporation of MWCNT with different functional groups, in the active layer, results in different cell performance with respect to a reference cell. A maximum power conversion efficiency of 2.5% is achieved with the inclusion of thiophene functionalized nanotubes. This improvement in the device performance is attributed to an extension of the exciton dissociation volume and charge transport properties through the nanotube percolation network in P3HT/CNT, PCBM/CNT or both phases. This is believed to be due to more efficient dispersion of the functionalized nanotubes within the photoactive composite layer. 相似文献