Concerted utility review of VVER-440 safety research needs (VERSAFE)

There are twelve operating VVER-440/213 reactors in the Czech Republic, Hungary and Slovakia. The plant owners have carried out extensive safety enhancement programmes, which have included measures to improve prevention, mitigation and control of design basis accidents. Recently, there have been a number of projects to study the Severe Accident Management aspects of these plants. The plant owners have also initiated Plant Life Management programmes. The objective of the VERSAFE Concerted Action is to create a network of the VVER-440/213 plant owners and operators, which aims at definition of the further research needs of severe accidents and plant ageing from the utilities’ viewpoint. The starting point is to formulate a general approach to severe accident management and plant life management and then proceed to define the needs for the additional information expected from the safety research. The role of national research institutes and organisations of the partner countries is of crucial importance in performing such research and, thus, creating and maintaining the expertise on the national level. The successful completion of the project will assist in establishing well-defined research projects that are oriented to the needs of the end-users and provide information that can be used to facilitate and support the negotiations of the EU applicant countries operating VVER-440 reactors.     

Comparing the effects of text size and format on the readibility of computer-displayed Times New Roman and Arial text

Times New Roman and Arial typefaces in 10- and 12-point, dot-matrix and anti-aliased format conditions were compared for readability (accuracy, reading speed, and accuracy/reading speed), as well as perceptions of typeface legibility, sharpness, ease of reading, and general preference. In assessing readability, the 10-point anti-aliased Arial typeface was read slower than the other type conditions. Examining perceptions of typeface legibility, sharpness, and ease of reading detected significant effects for typeface, size, and format. Overall, the 12-point dot-matrix Arial typeface was preferred to the other typefaces. Recommendations for appropriate typeface combinations for computer-displayed text are discussed.     

Stress transmission through three-dimensional granular crystals with stacking faults

We explore the effect of stacking fault defects on the transmission of forces in three-dimensional face-centered-cubic granular crystals. An external force is applied to a small area at the top surface of a crystalline packing of granular beads containing one or two stacking faults at various depths. The response forces at the bottom surface are measured and found to correspond to predictions based on vector force balance within the geometry of the defects. We identify the elementary stacking fault as a boundary between two pure face-centered-cubic crystals with different stacking orders. Other stacking faults produce response force patterns that can be viewed as resulting from repetitions of this basic defect. As the number of stacking faults increases, the intensity pattern evolves toward that of an hexagonal-close-packed crystal. This leads to the conclusion that the force pattern of that crystal structure can be viewed as the extreme limit of a face-centered-cubic crystal with a stacking fault at every layer.This work was supported by NSF-CTS 0090490 and by the NSF MRSEC Program under DMR-0213745. MJS acknowledges support by the University of Chicago MRSEC Summer 2002 REU program.     

A Comparative Study of Group Contingencies and Randomized Reinforcers to Reduce Disruptive Classroom Behavior.

The present investigation employed an alternating treatments design to (1) examine the efficacy of group contingencies in the reduction of disruptive behavior, and (2) compare the effects of independent, interdependent, and dependent group contingencies in the reduction of disruptive behavior in adolescent males identified with serious emotional disturbance. Disruptive classroom behavior has been associated with both decrement inacademic performance and increased risk for antisocial behavior. Although research findings have suggested that group contingencies are efficacious in reducing disruptive behavior, the data remain inconclusive regarding which group contingency (interdependent, dependent, and independent) is most effective. Results suggest that a clear superiority among the group contingencies was not evidenced. However, all were dramatically effective in the reduction of classroom disruptive behavior. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Culture and group perception: Dispositional and stereotypic inferences about novel and national groups.

In 3 studies, the authors tested the hypothesis that Chinese participants would view social groups as more entitative than would Americans and, as a result, would be more likely to infer personality traits on the basis of group membership--that is, to stereotype. In Study 1, Chinese participants made stronger stereotypic trait inferences than Americans did on the basis of a target's membership in a fictitious group. Studies 2 and 3 showed that Chinese participants perceived diverse groups as more entitative and attributed more internally consistent dispositions to groups and their members. Guided by culturally based lay theories about the entitative nature of groups, Chinese participants may stereotype more readily than do Americans when group membership is available as a source of dispositional inference. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fitting in and feeling fine: Conformity and coping motives as mediators of the relationship between social anxiety and problematic drinking.

The present research was conducted to clarify the relationships among social anxiety, alcohol consumption, alcohol-related problems, and negative-reinforcement drinking motives among college students. Heavy drinking students (N = 316, 53.80% female) completed self-report measures of social anxiety, alcohol consumption, alcohol-related problems, and drinking motives. Findings indicated that students higher in social anxiety consumed less alcohol but experienced more negative consequences. Moreover, the relationship between social anxiety and negative consequences was mediated by coping and conformity drinking motives in addition to alcohol consumption. In the context of social anxiety, the current research demonstrates the importance of examining problematic drinking as distinct constructs: alcohol consumption and negative consequences. Findings are also discussed in terms of implications for interventions with socially anxious students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy

Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS.     

An upgraded artificial bee colony (ABC) algorithm for constrained optimization problems

Artificial bee colony (ABC) algorithm developed by Karaboga is a nature inspired metaheuristic based on honey bee foraging behavior. It was successfully applied to continuous unconstrained optimization problems and later it was extended to constrained design problems as well. This paper introduces an upgraded artificial bee colony (UABC) algorithm for constrained optimization problems. Our UABC algorithm enhances fine-tuning characteristics of the modification rate parameter and employs modified scout bee phase of the ABC algorithm. This upgraded algorithm has been implemented and tested on standard engineering benchmark problems and the performance was compared to the performance of the latest Akay and Karaboga’s ABC algorithm. Our numerical results show that the proposed UABC algorithm produces better or equal best and average solutions in less evaluations in all cases.     

基于MPPMSG的混合高压直流风电系统故障穿越技术

为解决传统风电系统变换级数多的问题,文中提出了一种基于多相永磁同步电机(MPPMSG)的混合高压直流风电系统拓扑。电机多套绕组分别连接单极性变流器并在直流侧串联形成高压直接接入直流母线,一套绕组向电机注入无功功率以改善电机调速和稳态性能。岸上变电站采用电网换相换流器,直流母线短路时可阻断短路电流。为解决多绕组耦合问题,MPPMSG采用了反馈解耦的控制策略。根据发电机短路特性分析,提出了直流母线短路时限制电机短路电流以及直流故障穿越的控制策略。最后,利用PSCAD/EMTDC搭建风电系统开关电路仿真模型,验证了所提控制策略的有效性。     

Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-aged women, and it typically involves elevated androgen levels. Recently, it has been reported that human bone marrow mesenchymal stem cells (hBM-MSCs) can regulate androgen synthesis pathways. However, the details of the mechanism are still unclear. hBM-MSC-derived secreted factors (the secretome) are promising sources of cell-based therapy as they consist of various types of proteins. It is thus important to know which proteins interact with disease-implicated biomolecules. This work aimed to investigate which secretome components contain the key factor that inhibits testosterone synthesis. In this study, we fractionated hBM-MSC-conditioned media into three fractions based on their molecular weights and found that, of the three fractions, one had the ability to inhibit the androgen-producing genes efficiently. We also analyzed the components of this fraction and established a protein profile of the hBM-MSC secretome, which was shown to inhibit androgen synthesis. Our study describes a set of protein components present in the hBM-MSC secretome that can be used therapeutically to treat PCOS by regulating androgen production for the first time.