A 0.5 V offset cancelled latch comparator in standard 0.18 μm CMOS process

This paper presents a new 0.5 V high-speed dynamic latch comparator with built-in foreground offset cancellation capability and rail-to-rail input range. Traditional latch comparators lose their speed performance in low voltage condition, especially in sub-1V applications. The proposed latch comparator utilizes a speed-up technique based on a novel boosting method to mitigate the low voltage imperfections on circuit operation. Employing a new offset cancellation technique based on the same boosting capacitors is another key idea. This enhances the accuracy of the ultra low-voltage latch comparators and relaxes the need for preamplifier stage, which is conventionally used in the low offset latch comparator. The performed Monte Carlo simulations over corners in 0.18 μm standard CMOS process show the improvement of input referred offset voltage with a standard deviation of 29.9 mV/299 μV before and after offset cancellation, respectively. The designed comparator dissipates 34 μW power from 0.5 V voltage supply while operating in 200 MHz clock frequency and detects 1 mV input difference.     

Life cycle assessment of oxygen-18 production using cryogenic oxygen distillation

In this study, life cycle assessment of oxygen-18 by using cryogenic distillation of oxygen is performed using SimaPro 8.3 software. Life cycle assessment is performed to understand the environmental profile and hotspots of this process in order to be used in design and development. Simulation of oxygen-18 process is executed by Hysys software, and the required inputs and outputs for inventory of life cycle were acquired. By doing life cycle assessment and considering achieved results after characterization and normalization of inventory data it has been investigated that in the majority of environmental impacts electricity consumption has a huge contribution relative to other parts of the system like liquefied oxygen production from air separation unit, required facilities for air separation and oxygen-18 units, and needed transportation. Also, among 17 impact categories investigated in ReCiPe impact assessment method, fossil depletion, climate change (human health), particulate matter formation, climate change (ecosystem), human toxicity, and metal depletion have the most contribution in entire environmental loads respectively. Furthermore, sensitivity analysis showed that changing life cycle impact assessment method from ReCiPe to IMPACT 2002 + has no significant effect on acquired results and results are confident. In addition, assumption of market for depleted oxygen from heavy isotopes which is withdrawn from top of distillation columns showed some positive effects compared to first case and environmental impacts resulted from liquefied oxygen production (feed) reduced but because of huge contribution of electricity consumption compared to other sections, this positive effect has no remarkable influence on entire environmental loads of product system.     

Innovative Diagnostic Peptide-Based Technologies for Cancer Diagnosis: Focus on EGFR-Targeting Peptides

Active targeting using biological ligands has emerged as a novel strategy for the targeted delivery of diagnostic agents to tumor cells. Conjugating functional targeting moieties with diagnostic probes can increase their accumulation in tumor cells and tissues, enhancing signal detection and, thus, the sensitivity of diagnosis. Due to their small size, ease of chemical synthesis and site-specific modification, high tissue penetration, low immunogenicity, rapid blood clearance, low cost, and biosafety, peptides offer several advantages over antibodies and proteins in diagnostic applications. Epidermal growth factor receptor (EGFR) is one of the most promising cancer biomarkers for actively targeting diagnostic and therapeutic agents to tumor cells due to its active involvement and overexpression in various cancers. Several peptides for EGFR-targeting have been identified in the last decades, which have been obtained by multiple means including derivation from natural proteins, phage display screening, positional scanning synthetic combinatorial library, and in silico screening. Many studies have used these peptides as a targeting moiety for diagnosing different cancers in vitro, in vivo, and in clinical trials. This review summarizes the progress of EGFR-targeting peptide-based assays in the molecular diagnosis of cancer.     

Power and energy consumption of skid-steer rovers turning on loose soil

This study highlights two key phenomena affecting power and energy consumption of skid-steer rovers on loose soil that is not present on the hard ground: soil excavation due to wheel counterrotation and impeded turning when dragging a braked wheel. Experiments in the field and in a controlled laboratory sandbox show that, on sand, power peaks by 15%–20% in a newly identified range of turns with radii between half the rover width, $B∕2$, to $R^{\prime }$, the radius at which the inner wheel does not turn. In this range of turns, the inner wheels rotate backwards but are being dragged forward through piles of sand they excavate by counterrotation. At $R\prime$, turns are shown to take much longer, leading to higher total energy consumption over time. Experiments in a controlled laboratory sandbox isolate the high motor torque and the resistance force experienced when a skid-steer rover drags a counterrotating or braked wheel, respectively, through loose soil. Other field experiments also demonstrate that paths combining circular arcs and lines can lead to energy savings of up to 15% relative to common ones consisting of point turns and lines; the experimental results suggest the circular arcs should have radii of approximately $2R\prime$. The quantitative values presented in this paper are specific to the rover and soils tested, but there are reasons to support the overall conclusions generalizing to all skid-steer rovers in loose soil.