Effect of Clay Modification on the Mechanism of Local Deformations in PA6 Nanocomposites

PA nanocomposites are prepared from clays organophilized with a phosphonium and an ammonium salt, and sodium montmorillonite is used as reference. The analysis of mechanical and micromechanical properties of the composites reveal that several micromechanical deformation processes occur in the PA/MMT composites. The matrix cavitates at relatively small stress. Processes related to non‐exfoliated clay structural units are initiated at larger stresses. Sound is emitted mainly by the fracture of particles, but debonding may also occur. The plastic deformation of the matrix dominates at larger stresses and deformations. The various local deformations are independent of each other and composite properties are not determined by silicate related processes but by the deformation of the matrix.

     

Amino Acid and Peptide-Based Antiviral Agents

A significant number of antiviral agents used in clinical practice are amino acids, short peptides, or peptidomimetics. Among them, several HIV protease inhibitors (e. g. lopinavir, atazanavir), HCV protease inhibitors (e. g. grazoprevir, glecaprevir), and HCV NS5A protein inhibitors have contributed to a significant decrease in mortality from AIDS and hepatitis. However, there is an ongoing need for the discovery of new antiviral agents and the development of existing drugs; amino acids, both proteinogenic and non-proteinogenic in nature, serve as convenient building blocks for this purpose. The synthesis of non-proteinogenic amino acid components of antiviral agents could be challenging due to the need for enantiomerically or diastereomerically pure products. Herein, we present a concise review of antiviral agents whose structures are based on amino acids of both natural and unnatural origin. Special attention is paid to the synthetic aspects of non-proteinogenic amino acid components of those agents.     

The Benefit of Using an Ensemble of Global Hydrological Models in Surface Water Availability for Irrigation Area Planning

Water Resources Management - Hydrological data and information on the availability of water are essential to support water allocation decisions in irrigated agriculture, especially under...     

Laboratory Full-Scale Comparative Tests of Rigid and Flexible Foundations of Buried Steel Structures

International Journal of Steel Structures - The technical issues described in the article concern the aspects of the implementation of foundations for buried flexible steel structures. The...     

Separability of Mixed Quantum States: Linear Contractions and Permutation Criteria

Recently, a powerful separability criterion was introduced by O. Rudolf in [5] and by K. Chen et al. in [6] – basing on realignment of elements of density matrix. Composing the main idea behind the above criterion and the necessary and sufficient condition in terms of positive maps, we provide a characterization of separable states by means of linear contractions. The latter need not be positive maps. We extend the idea to multipartite systems, and find that, somewhat suprisingly, partial realigment (unlike partial transposition) can detect genuinely tri-parite entanglement. We generalize it by introducing a family of so called permutation separability criteria for multipartite states. Namely, any permutation of indices of density matrix written in product basis leads to a separability criterion. Partial transpose and realignment criterion are special cases of permutation criteria. An early version of the present paper has appeared in e-print archive as quant-ph/0206008. The premutation criterion has been then further developed in [23, 24, 25], where the problem of classification of inequivalent permutation criteria has been investigated.     

Randomized incremental construction of Delaunay and Voronoi diagrams

In this paper we give a new randomized incremental algorithm for the construction of planar Voronoi diagrams and Delaunay triangulations. The new algorithm is more on-line than earlier similar methods, takes expected timeO(ngn) and spaceO(n), and is eminently practical to implement. The analysis of the algorithm is also interesting in its own right and can serve as a model for many similar questions in both two and three dimensions. Finally we demonstrate how this approach for constructing Voronoi diagrams obviates the need for building a separate point-location structure for nearest-neighbor queries.Leonidas Guibas and Micha Sharir wish to acknowledge the generous support of the DEC Systems Research Center in Palo Alto, California, where some of this work was carried out. Donald Knuth has been supported by NSF Grant CCR-86-10181. Micha Sharir has been supported by NSF Grant CCR-89-01484, ONR Grant N00014-K-87-0129, the U.S.-Israeli Binational Science Foundation, and the Fund for Basic Research administered by the Israeli Academy of Sciences.     

Cyclopropaneoctanoic Acid 2‐Hexyl Upregulates the Expression of Genes Responsible for Lipid Synthesis and Release in Human Hepatic HepG2 Cells

Recently we have found cyclopropaneoctanoic acid 2‐hexyl (CPOA2H) in humans and demonstrated its elevated levels in patients with metabolic diseases associated with hypertriglyceridemia. However, it is still unclear whether CPOA2H may influence lipid metabolism in lipogenic tissues. To verify this, HepG2 hepatocytes and 3T3‐L1 adipocytes were cultured with various concentrations of CPOA2H, and then the expressions of genes associated with lipid metabolism were determined. Incubation with CPOA2H at concentrations found in patients with metabolic diseases enhanced the expression of hepatocyte genes associated with lipid synthesis and release, in particular, the fatty acid synthase gene (nearly 20‐fold increase in the mRNA level). In contrast, incubation with CPOA2H caused the downregulation of most adipocyte genes associated with lipid synthesis, whereas the level of leptin mRNA was increased. These findings suggest that CPOA2H may contribute to hypertriglyceridemia in patients with metabolic diseases, upregulating the expression of hepatocyte genes responsible for lipid synthesis and release.     

Experimental Determination of the Length-Scale Parameter for the Phase-Field Modeling of Macroscale Fracture in Cr–Al2O3 Composites Fabricated by Powder Metallurgy

Metallurgical and Materials Transactions A - A novel approach is proposed to determine a physically meaningful length-scale parameter for the phase-field modeling of macroscale fracture in...     

Workflow management system with smart procedures

Supervision of repair and diagnostic works aimed at improving the safety of maintenance crews is one of the key objectives of the distributed INRED system. Working in a real industrial environment, the INRED system includes, among others, the so-called INRED-Workflow, which provides an infrastructure for process automation. Participants of the service processes, managed by the INRED-Workflow, are controlled at each stage of the performed service procedures, both by the system and other process participants, such as quality managers and technologists. All data collected from the service processes is stored in the System Knowledge Repository (SKR) for further processing by using advanced algorithms, and the so-called Smart Procedures merge services supplied by other INRED system modules. The applicability of workflow management systems in conjunction with image recognition and machine learning methods has not yet been thoroughly explored. The presented paper shows the innovative usage of such systems in the supervision of the repair and diagnostic works.