Autonome Maschinen oder komplexe Automaten – wer ist für Algorithmen verantwortlich?

One of the fundamental questions discussed in the course of the development towards Industry 4.0 is that of responsibility for machines. The inner-juridical discussion of this issue suffers from the unclear concept of artificial intelligence and the fascination about the creation of very high technical performance while lightning-fast access to a huge amount of information or the determination of previously undiscovered correlations between individual phenomena is no indication of the appearance of the superhuman. Technicians, on the other hand, are confused about the differentiations by which lawyers approach the question of responsibility. This article aims at bridging the gap in order to strengthen the interdisciplinary dialogue.     

Synthese von Benzo[b]thioxanthenen

Synthesis of Benzo[b]thioxanthenes Benzo[b]thioxanthenes, heterocyclic compounds related to tetracenes and tetracyclines can be obtained by the reaction of 2H-benzo[b]thiete ( 1 ) and 1,4-naphthoquinones ( 3a–g ). The primary cycloadducts 4a–g undergo an autoxidation process leading to the quinones 6a–g . The dihydroxy compound 4e shows an additional isomerization by a tetrafold H transfer ( 4e → 5e ′). Another preparative route to benzo[b]thioxanthenes makes use of the cycloadditon reaction of 1 and 1,4-epoxynaphthalenes ( 7a–d ). The primary adducts can be transformed to the title compounds by catalytic dehydration processes ( 8a–d → 9a-d ). An alternate regioselective opening of the oxygen bridge can be performed by the action of trimethyliodosilane ( 8a → 10a ). Methylation of 9a furnishes the sulfonium salt 14a which rearranges in a strongly alkaline medium to 16a ; in the presence of oxygen ketone 17a is generated.     

健康与纺织品:挑战与机遇

综述了能促进消费者健康和社会安宁的纺织品的最新的技术发展.介绍了种种创新的纺织品.社会的变革和发展趋势愈来愈强调生活环境、休闲娱乐、通信以及交通等的健康与安宁的重要性.最近的技术发展增加了使纺织品获得新性能的可能性,并直接关系到使用者的健康和生活环境.纺织品作为一种柔性材料,具有悬垂性好、弹性好、易变形、强度较高、较好的染色吸附性以及其他后处理特性,可以由多种原料制成,并具有多种功能.     

Enol cation radicals in solution. 4. An improved Synthesis of 4,6,7-Trimethylbenzofurans by oxidation of β-mesityl substituted enols

An improved synthetic access for the construction of 4,6,7-trimethylbenzofurans ( B1–B8 ) through the one-electron oxidation of mesityl-substituted enols ( E1–E8 ) is presented. The transformation can be accomplished in good to excellent yields by using various oxidants; i.e. tris(1,10-phenanthroline)iron(III) hexafluorophosphate, FeCl₃, Ce(NH₄)₂(NO₃)₆, Cu(OTf)₂/Cu₂O or anodic oxidation.     

Male Rat Offspring Are More Impacted by Maternal Obesity Induced by Cafeteria Diet than Females—Additive Effect of Postweaning Diet

Maternal obesity increases the risk of health complications in offspring, but whether these effects are exacerbated by offspring exposure to unhealthy diets warrants further investigation. Female Sprague-Dawley rats were fed either standard chow (n = 15) or ‘cafeteria’ (Caf, n = 21) diets across pre-pregnancy, gestation, and lactation. Male and female offspring were weaned onto chow or Caf diet (2–3/sex/litter), forming four groups; behavioural and metabolic parameters were assessed. At weaning, offspring from Caf dams were smaller and lighter, but had more retroperitoneal (RP) fat, with a larger effect in males. Maternal Caf diet significantly increased relative expression of ACACA and Fasn in male and female weanling liver, but not CPT-1, SREBP and PGC1; PPARα was increased in males from Caf dams. Maternal obesity enhanced the impact of postweaning Caf exposure on adult body weight, RP fat, liver mass, and plasma leptin in males but not females. Offspring from Caf dams appeared to exhibit reduced anxiety-like behaviour on the elevated plus maze. Hepatic CPT-1 expression was reduced only in adult males from Caf fed dams. Post weaning Caf diet consumption did not alter liver gene expression in the adult offspring. Maternal obesity exacerbated the obesogenic phenotype produced by postweaning Caf diet in male, but not female offspring. Thus, the impact of maternal obesity on adiposity and liver gene expression appeared more marked in males. Our data underline the sex-specific detrimental effects of maternal obesity on offspring.     

FAK in Cancer: From Mechanisms to Therapeutic Strategies

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and activated in many cancer types. FAK regulates diverse cellular processes, including growth factor signaling, cell cycle progression, cell survival, cell motility, angiogenesis, and the establishment of immunosuppressive tumor microenvironments through kinase-dependent and kinase-independent scaffolding functions in the cytoplasm and nucleus. Mounting evidence has indicated that targeting FAK, either alone or in combination with other agents, may represent a promising therapeutic strategy for various cancers. In this review, we summarize the mechanisms underlying FAK-mediated signaling networks during tumor development. We also summarize the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.     

用于白色LED的电源

随着大型彩色或黑白LCD显示屏的发展,LED技术也不断进步,可用更低的功率产生更强的光,多用作便携式或交流线路供电系统照明源。现在,白色LED能够提供与普通白炽灯泡几乎一样或更多的光源。