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91.
Michela Pecoraro Stefania Marzocco Ada Popolo 《International journal of molecular sciences》2021,22(21)
Hypoxia is the leading cause of death in cardiomyocytes. Cells respond to oxygen deprivation by activating cytoprotective programs, such as mitochondrial connexin43 (mCx43) overexpression and the opening of mitochondrial KATP channels, aimed to reduce mitochondrial dysfunction. In this study we used an in vitro model of CoCl2-induced hypoxia to demonstrate that mCx43 and KATP channels cooperate to induce cytoprotection. CoCl2 administration induces apoptosis in H9c2 cells by increasing mitochondrial ROS production, intracellular and mitochondrial calcium overload and by inducing mitochondrial membrane depolarization. Diazoxide, an opener of KATP channels, reduces all these deleterious effects of CoCl2 only in the presence of mCx43. In fact, our results demonstrate that in the presence of radicicol, an inhibitor of Cx43 translocation to mitochondria, the cytoprotective effects of diazoxide disappear. In conclusion, these data confirm that there exists a close functional link between mCx43 and KATP channels. 相似文献
92.
A radio frequency glow discharge mass spectrometry (rf‐GDMS) source is evaluated for future applications in the “fingerprint” characterization of polyphosphazene membranes. The rf‐GDMS spectra of a series of bis(phenoxy)phosphazene polymers contain ions that originate from both the phosphazene backbone and the phenoxy moiety, resulting in signature ions of the polymer family. “Fingerprint” ions from the substituted R‐group on the phenoxy moiety of the different derivatives allows the individual polymers to be distinguished from one another. The ability of the rf‐GDMS source to characterize these materials directly in the solid state will be useful for the continued application of these polymers as separation membranes. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 76: 954–961, 2000 相似文献
93.
Filippo Piccinini Michela Pierini Enrico Lucarelli Alessandro Bevilacqua 《Journal of materials science. Materials in medicine》2014,25(10):2395-2410
The analysis of cell confluence and proliferation is essential to design biomaterials and scaffolds to use as bone substitutes in clinical applications. Accordingly, several approaches have been proposed in the literature to estimate the area of the scaffold covered by cells. Nevertheless, most of the approaches rely on sophisticated equipment not employed for routine analyses, while the rest of them usually do not provide significant statistics about the cell distribution. This research aims at studying confluence and proliferation of mesenchymal stromal cells (MSC) adherent on OSPROLIFE®, a commercial biomaterial in the form of granules. In particular, we propose a Computer Vision approach that can routinely be employed to monitor the surface of the single granules covered by cells because only a standard widefield fluorescent microscope is required. In order to acquire significant statistics data, we analyse wide-area images built by using MicroMos v2.0, an updated version of a previously published software specific for stitching brightfield and phase-contrast images manually acquired via a widefield microscope. In particular, MicroMos v2.0 permits to build accurate “mosaics” of fluorescent images, after correcting vignetting and photo-bleaching effects, providing a consistent representation of a sample region containing numerous granules. Then, our method allows to make automatically a statistically significant estimate of the percentage of the area of the single granules covered by cells. Finally, by analysing hundreds of granules at different time intervals we also obtained reliable data regarding cell proliferation, confirming that not only MSC adhere onto the OSPROLIFE® granules, but even proliferate over time. 相似文献
94.
95.
Muscetti Michela Rinaldi Antonio M. Russo Cristiano Tommasino Cristian 《Knowledge and Information Systems》2022,64(5):1283-1303
Knowledge and Information Systems - The rapid increase of available data in different complex contexts needs automatic tasks to manage and process contents. Semantic Web technologies represent the... 相似文献
96.
97.
Minella M Rogora M Vione D Maurino V Minero C 《The Science of the total environment》2011,409(18):3463-3471
A model-based approach is here developed and applied to predict the long-term trends of indirect photochemical processes in the surface layer (5 m water depth) of Lake Maggiore, NW Italy. For this lake, time series of the main parameters of photochemical importance that cover almost two decades are available. As a way to assess the relevant photochemical reactions, the modelled steady-state concentrations of important photogenerated transients (•OH, 3CDOM* and CO3-•) were taken into account. A multivariate analysis approach was adopted to have an overview of the system, to emphasise relationships among chemical, photochemical and seasonal variables, and to highlight annual and long-term trends. Over the considered time period, because of the decrease of the dissolved organic carbon (DOC) content of water and of the increase of alkalinity, a significant increase is predicted for the steady-state concentrations of the radicals •OH and CO3−•. Therefore, the photochemical degradation processes that involve the two radical species would be enhanced. Another issue of potential photochemical importance is related to the winter maxima of nitrate (a photochemical •OH source) and the summer maxima of DOC (•OH sink and 3CDOM* source) in the lake water under consideration. From the combination of sunlight irradiance and chemical composition data, one predicts that the processes involving •OH and CO3−• would be most important in spring, while the reactions involving 3CDOM* would be most important in summer. 相似文献
98.
Ruffolo Silvestro A. La Russa Mauro F. Ricca Michela Belfiore Cristina M. Macchia Andrea Comite Valeria Pezzino Antonino Crisci Gino M. 《Bulletin of Engineering Geology and the Environment》2017,76(1):11-20
Bulletin of Engineering Geology and the Environment - The deterioration of a stone material is related to its pore structure, which affects the interaction between surface and environmental agents.... 相似文献
99.
La Russa Mauro F. Ruffolo Silvestro A. de Buergo Mónica Álvarez Ricca Michela Belfiore Cristina M. Pezzino Antonino Crisci Gino M. 《Bulletin of Engineering Geology and the Environment》2017,76(1):115-124
Bulletin of Engineering Geology and the Environment - Salt crystallization is a strong weathering agent in porous building materials. The crystallization pressure exerted by salt crystals, growing... 相似文献
100.