Detecting cracks in pipes filled with fluid from changes in natural frequencies

This paper deals with the identification of a single open crack in a straight pipe containing fluid under pressure by frequency measurements. The crack is assumed to be a transverse partial cut of the pipe wall thickness with straight front and it is simulated by an equivalent elastic spring. It is shown that the measurement of the damage-induced shifts in a pair of natural frequencies of the bending vibration can be used to formulate and solve the diagnostic problem. In particular, it is shown that the change in the first two frequencies in a simply supported uniform pipe is sufficient to localize a small crack, except for a symmetrical position, and to determine the damage severity. Closed-form expressions are provided for damage location and severity. An extension of the method to simply supported uniform pipe with two cracks of equal severity is also presented. The analysis is based on an explicit expression of the frequency sensitivity to damage and allows to consider pipes under general set of boundary conditions. Analytical results agree well with the numerical tests.     

Insights into Intra-Tumoral Heterogeneity: Transcriptional Profiling of Chemoresistant MPM Cell Subpopulations Reveals Involvement of NFkB and DNA Repair Pathways and Contributes a Prognostic Signature

Chemoresistance is a hallmark of malignant pleural mesothelioma (MPM) management and the expression of ALDH1A3 is responsible for the survival and activity of MPM chemoresistant cell subpopulations (ALDH^bright cells). We enriched mesothelioma ALDH^bright cells to near homogeneity by FACS sorting and an Aldefluor assay and performed unbiased Affymetrix gene expression profiling. Viability and ELISA assays were used to rule out significant apoptosis in the sorted cell subpopulations and to assess target engagement by butein. Statistical analysis of the results, pathway enrichment and promoter enrichment were employed for the generation of the data. Q-RTPCR was used to validate a subset of the identified, modulated mRNAs In this work, we started from the observation that the mRNA levels of the ALDH1A3 isoform could prognostically stratify MPM patients. Thus, we purified MPM ALDH^bright cells from NCI-H2595 cells and interrogated their gene expression (GES) profile. We analyzed the GES of the purified cells at both a steady state and upon treatment with butein (a multifunctional tetrahydroxy-chalcone), which abates the ALDH^bright cell number, thereby exerting chemo-sensitizing effects in vitro and in vivo. We identified 924 genes modulated in a statistically significant manner as a function of ALDH status and of the response to the inhibitor. Pathway and promoter enrichment identified the molecular determinant of high ALDH status and how butein treatment altered the molecular portrait of those chemoresistant cell subpopulations. Further, we unraveled an eighteen-gene signature with high prognostic significance for MPM patients, and showed that most of the identified prognostic contributors escaped the analysis of unfractionated samples. This work proves that digging into the unexplored field of intra-tumor heterogeneity (ITH) by working at the cell subpopulation level may provide findings of prognostic relevance, in addition to mechanistic insights into tumor resistance to therapy.     

Electrokinetic removal of 2,6-dichlorophenol and diuron from kaolinite and humic acid-clay system

This paper presents the results of a study on the electrokinetic treatment of kaolinite and humic acid kaolinite complexes spiked with 2,6-dichlorophenol or 3-(3,4-dichlorophenyl)-1,1-dimethylurea (diuron). In particular, the attention was paid to the interaction between solid surface and dissolved organics: the effects of contaminant sorption as well as the physicochemical reactions on the efficiency of electrokinetic remediation were investigated. Using a 3V/cm voltage gradient, approximately 90% of diuron was removed from kaolinite after one water pore volume was collected in the cathode reservoir, but much lower efficiency was obtained in the electrokinetic removal of this compound from humic acid-coated kaolinite. The results also showed that partial degradation of the contaminant occurred during electrokinetic treatment of kaolinite clay spiked with 2,6-dichlorophenol: the contamination in the clay could be remediated by the combination of electrokinetic extraction and electrochemical reactions.     

A system for in-vivo cardiac optical mapping

Optical mapping of cardiac electrical activity is a valuable technique for studying arrhythmias, particularly the effects of defibrillation shocks. This technique has been exclusively applied to in-vitro preparations of hearts or tissues removed from an animal. But verification of experimental results and hypotheses is ideally performed in vivo on the heart as it remains in place in the animal. However, in-vitro optical mapping instrumentation and techniques cannot be easily applied in vivo. This article describes a system the authors developed to address this problem     

Restarted Iterated Pareto Greedy algorithm for multi-objective flowshop scheduling problems

Multi-objective optimisation problems have seen a large impulse in the last decades. Many new techniques for solving distinct variants of multi-objective problems have been proposed. Production scheduling, as with other operations management fields, is no different. The flowshop problem is among the most widely studied scheduling settings. Recently, the Iterated Greedy methodology for solving the single-objective version of the flowshop problem has produced state-of-the-art results. This paper proposes a new algorithm based on Iterated Greedy technique for solving the multi-objective permutation flowshop problem. This algorithm is characterised by an effective initialisation of the population, management of the Pareto front, and a specially tailored local search, among other things. The proposed multi-objective Iterated Greedy method is shown to outperform other recent approaches in comprehensive computational and statistical tests that comprise a large number of instances with objectives involving makespan, tardiness and flowtime. Lastly, we use a novel graphical tool to compare the performances of stochastic Pareto fronts based on Empirical Attainment Functions.     

A Brief Survey of our Contribution to Stable Carbene Chemistry

This personal account summarizes our work, beginning with the discovery of the first stable carbene in 1988 up until the recent isolation of mesoionic carbenes. It explains why we have moved our focus from acyclic to cyclic carbenes, and shows that these stable species are not limited to the role of ligand for transition metals, but that they are also powerful agents for the activation of small molecules, and for the stabilization of highly reactive diamagnetic and paramagnetic species.     

A Decision Support System Based on AHP for Ranking Strategies to Manage Emergencies on Drinking Water Supply Systems

Water Resources Management - The provision of critical services, such as drinking water, is crucial both in ordinary and in emergency conditions due to either natural (e.g. earthquakes, droughts,...     

Regulatory focus as a mediator of the influence of initiating structure and servant leadership on employee behavior.

In this research, the authors test a model in which the regulatory focus of employees at work mediates the influence of leadership on employee behavior. In a nationally representative sample of 250 workers who responded over 2 time periods, prevention focus mediated the relationship of initiating structure to in-role performance and deviant behavior, whereas promotion focus mediated the relationship of servant leadership to helping and creative behavior. The results indicate that even though initiating structure and servant leadership share some variance in explaining other variables, each leadership style incrementally predicts disparate outcomes after controlling for the other style and dispositional tendencies. A new regulatory focus scale, the Work Regulatory Focus (WRF) Scale, also was developed and initially validated for this study. Implications for the results and the WRF Scale are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

People''s clothing behaviour according to external weather and indoor environment

In prehistoric times man wore furs of animals to protect himself from the cold. Successively over the centuries clothing has become also a tool to distinguish ourselves in society. Clothing has in addition an important impact on people's perception of the indoor environment.

Clothing behaviour has been analysed by investigating the external and indoor parameters that motivate people's choice of clothing. Based on two existing databases, two types of buildings have been investigated: air-conditioned and naturally ventilated (NV) buildings. The impact of outdoor temperature on people's clothing selection has been considered. The outdoor temperature at 6 a.m. seems to affect people's choice of clothes the most. Gender does not significantly affect the selection of clothing insulation.

Latitude has also been investigated and a good correlation has been found between clothing insulation and external temperature in the ranges 20°–40° and −20° to −40° for NV buildings.

Indoor air temperature does not seem to influence the clothing choice early in the morning but it does seem to influence the change of clothing during the day, if this is authorized, in workplaces in NV buildings. Such action can be termed “clothing adjustment” during the day.

Some computer simulations on a test reference year have been carried out for a typical air-conditioned office to analyse a person's comfort when wearing different clothes. It is possible to see that in air-conditioned buildings a variation of 0.1 clo is sufficient to change totally the comfort evaluation. It is evident that further studies are needed in this field.