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排序方式: 共有2056条查询结果,搜索用时 15 毫秒
21.
Davide Barbagallo Angela Caponnetto Cristina Barbagallo Rosalia Battaglia Federica Mirabella Duilia Brex Michele Stella Giuseppe Broggi Roberto Altieri Francesco Certo Rosario Caltabiano Giuseppe Maria Vincenzo Barbagallo Carmelina Daniela Anfuso Gabriella Lupo Marco Ragusa Cinzia Di Pietro Thomas Birkballe Hansen Michele Purrello 《International journal of molecular sciences》2021,22(4)
Circular RNAs (circRNAs) are a large class of RNAs with regulatory functions within cells. We recently showed that circSMARCA5 is a tumor suppressor in glioblastoma multiforme (GBM) and acts as a decoy for Serine and Arginine Rich Splicing Factor 1 (SRSF1) through six predicted binding sites (BSs). Here we characterized RNA motifs functionally involved in the interaction between circSMARCA5 and SRSF1. Three different circSMARCA5 molecules (Mut1, Mut2, Mut3), each mutated in two predicted SRSF1 BSs at once, were obtained through PCR-based replacement of wild-type (WT) BS sequences and cloned in three independent pcDNA3 vectors. Mut1 significantly decreased its capability to interact with SRSF1 as compared to WT, based on the RNA immunoprecipitation assay. In silico analysis through the “Find Individual Motif Occurrences” (FIMO) algorithm showed GAUGAA as an experimentally validated SRSF1 binding motif significantly overrepresented within both predicted SRSF1 BSs mutated in Mut1 (q-value = 0.0011). U87MG and CAS-1, transfected with Mut1, significantly increased their migration with respect to controls transfected with WT, as revealed by the cell exclusion zone assay. Immortalized human brain microvascular endothelial cells (IM-HBMEC) exposed to conditioned medium (CM) harvested from U87MG and CAS-1 transfected with Mut1 significantly sprouted more than those treated with CM harvested from U87MG and CAS-1 transfected with WT, as shown by the tube formation assay. qRT-PCR showed that the intracellular pro- to anti-angiogenic Vascular Endothelial Growth Factor A (VEGFA) mRNA isoform ratio and the amount of total VEGFA mRNA secreted in CM significantly increased in Mut1-transfected CAS-1 as compared to controls transfected with WT. Our data suggest that GAUGAA is the RNA motif responsible for the interaction between circSMARCA5 and SRSF1 as well as for the circSMARCA5-mediated control of GBM cell migration and angiogenic potential. 相似文献
22.
Oxidation reactivity studies are imperative for improving carbon re-burn technologies and valuing the heat content of unburned carbon within coal combustion ashes. Non-isothermal, thermal gravimetric analysis (TGA) was used to examine the oxidation kinetics of unburned carbon in coal combustion fly ashes having different particle size distributions; TGA results were related to combustion efficiencies as measured in a bench-scale rotary kiln. The activation energy and pre-exponential factor were determined for the chemically-controlled reaction regime; the transition temperatures between chemically-controlled and partially diffusion-controlled combustion regimes were obtained for unburned carbon particles of different sizes. After the oxidation reaction rates were evaluated, the residence time distribution (RTD) of fly ashes in the rotary kiln were experimentally measured and the mean residence times related to process parameters, including the rotating velocity and kiln inclination. By comparing these results with an advective-dispersive model, the axial dispersion coefficient of fly ashes was determined. The reaction rates obtained by thermal analyses and the RTDs were used to predict combustion efficiencies within the kiln and oxidation conditions of unburned carbon using various processing options. 相似文献
23.
Sutharshan Rajasegarar Alexander Gluhak Muhammad Ali Imran Michele Nati Masud Moshtaghi Christopher Leckie Marimuthu Palaniswami 《Pattern recognition》2014
Anomaly detection in resource constrained wireless networks is an important challenge for tasks such as intrusion detection, quality assurance and event monitoring applications. The challenge is to detect these interesting events or anomalies in a timely manner, while minimising energy consumption in the network. We propose a distributed anomaly detection architecture, which uses multiple hyperellipsoidal clusters to model the data at each sensor node, and identify global and local anomalies in the network. In particular, a novel anomaly scoring method is proposed to provide a score for each hyperellipsoidal model, based on how remote the ellipsoid is relative to their neighbours. We demonstrate using several synthetic and real datasets that our proposed scheme achieves a higher detection performance with a significant reduction in communication overhead in the network compared to centralised and existing schemes. 相似文献
24.
Yasmin AlNoamany Ahmed AlSum Michele C. Weigle Michael L. Nelson 《International Journal on Digital Libraries》2014,14(3-4):101-115
The Internet Archive’s (IA) Wayback Machine is the largest and oldest public Web archive and has become a significant repository of our recent history and cultural heritage. Despite its importance, there has been little research about how it is discovered and used. Based on Web access logs, we analyze what users are looking for, why they come to IA, where they come from, and how pages link to IA. We find that users request English pages the most, followed by the European languages. Most human users come to Web archives because they do not find the requested pages on the live Web. About 65 % of the requested archived pages no longer exist on the live Web. We find that more than 82 % of human sessions connect to the Wayback Machine via referrals from other Web sites, while only 15 % of robots have referrers. Most of the links (86 %) from Websites are to individual archived pages at specific points in time, and of those 83 % no longer exist on the live Web. Finally, we find that users who come from search engines browse more pages than users who come from external Web sites. 相似文献
25.
Roberto J. de Antueno Richard C. Cantrill Yung-Sheng Huang Michele Elliot David F. Horrobin 《Lipids》1993,28(4):285-290
This study was undertaken to investigate the total plasma fatty acid composition and the relationship between plasma triacylglycerol
(TG) levels and liver Δ9 desaturase activity in mice fed n−3 and/or n−6 fatty acid or hydrogenated coconut oil (HCO) (maximum
25 mg/g) supplemented diets. Generally, plasma TG levels and Δ9 desaturase activity were inversely correlated with the ratio
of the sum of long chain n−3 fatty acids to 18∶2n−6 and to the ratio of the sum of long chain n−3 fatty acids to 18∶n−3, but
they were positively correlated with the ratio of products and substrates (18∶1/18∶0) of the enzyme in plasma total lipids.
The n−3 fatty acid (mainly 20∶5n−3) enriched diet, when compared to the HCO diet at 21 d, caused a significant reduction in
plasma TG levels but not in Δ9 desaturase activity. However, a marked reduction in plasma TG content (50–60%) and Δ9 desaturase
activity (55–70%) was observed when both 20∶5n−3 and 18∶3n−6 were supplemented in the diet. The plasma TG levels and Δ9 desaturase
activity rose again when the animals were fed the HCO diet or chow. The results suggest that low dose supplementation of a
mixture of n−3 (mainly 20∶5n−3) and n−6 (18∶3n−6) fatty acids modified both plasma TG content and liver Δ9 desaturase activity,
in parallel. 相似文献
26.
Zhang Yingqian Lombardi Michele De Causmaecker Patrick 《Annals of Mathematics and Artificial Intelligence》2021,89(7):615-616
Annals of Mathematics and Artificial Intelligence - 相似文献
27.
This paper discusses a new method to perform propagation over a (two-layer, feed-forward) Neural Network embedded in a Constraint Programming model. The method is meant to be employed in Empirical Model Learning, a technique designed to enable optimal decision making over systems that cannot be modeled via conventional declarative means. The key step in Empirical Model Learning is to embed a Machine Learning model into a combinatorial model. It has been showed that Neural Networks can be embedded in a Constraint Programming model by simply encoding each neuron as a global constraint, which is then propagated individually. Unfortunately, this decomposition approach may lead to weak bounds. To overcome such limitation, we propose a new network-level propagator based on a non-linear Lagrangian relaxation that is solved with a subgradient algorithm. The method proved capable of dramatically reducing the search tree size on a thermal-aware dispatching problem on multicore CPUs. The overhead for optimizing the Lagrangian multipliers is kept within a reasonable level via a few simple techniques. This paper is an extended version of [27], featuring an improved structure, a new filtering technique for the network inputs, a set of overhead reduction techniques, and a thorough experimentation. 相似文献
28.
Yasmin AlNoamany Michele C. Weigle Michael L. Nelson 《International Journal on Digital Libraries》2016,17(3):203-221
Web archives have become a significant repository of our recent history and cultural heritage. Archival integrity and accuracy is a precondition for future cultural research. Currently, there are no quantitative or content-based tools that allow archivists to judge the quality of the Web archive captures. In this paper, we address the problems of detecting when a particular page in a Web archive collection has gone off-topic relative to its first archived copy. We do not delete off-topic pages (they remain part of the collection), but they are flagged as off-topic so they can be excluded for consideration for downstream services, such as collection summarization and thumbnail generation. We propose different methods (cosine similarity, Jaccard similarity, intersection of the 20 most frequent terms, Web-based kernel function, and the change in size using the number of words and content length) to detect when a page has gone off-topic. Those predicted off-topic pages will be presented to the collection’s curator for possible elimination from the collection or cessation of crawling. We created a gold standard data set from three Archive-It collections to evaluate the proposed methods at different thresholds. We found that combining cosine similarity at threshold 0.10 and change in size using word count at threshold ?0.85 performs the best with accuracy = 0.987, \(F_{1}\) score = 0.906, and AUC \(=\) 0.968. We evaluated the performance of the proposed method on several Archive-It collections. The average precision of detecting off-topic pages in the collections is 0.89. 相似文献
29.
Michele Amoretti Alessandro Grazioli Francesco Zanichelli 《Peer-to-Peer Networking and Applications》2016,9(6):1226-1241
The rise of Cloud Computing has progressively dimmed the interest in volunteer and peer-to-peer computing, in general. However, efficient and cost-effective large scale distributed collaborative environments cannot be achieved leveraging upon the Cloud alone. In this paper, we propose a novel hybrid P2P/cloud approach where components and protocols are autonomically configured according to specific target goals, such as cost-effectiveness, reliability and availability. The proposed approach is based on the Networked Autonomic Machine (NAM) framework, which allows distributed system designers to include different kinds of cost and performance constraints. As an example, we show how the NAM-based approach can be used to design collaborative storage systems, enabling the definition of an autonomic policy to decide, according to cost minimization and data availability goals, how to part data chunks among peer nodes and Cloud, based on the local perception of the P2P network. 相似文献
30.
Recent vehicular routing proposals use real-time road traffic density estimates to dynamically select forwarding paths. Estimating the traffic density in vehicular ad hoc networks requires the transmission of additional dedicated messages increasing the communications load. These proposals are generally based on unicast sender-based forwarding schemes. The greedy nature of sender-based forwarding can result in the selection of forwarders with weak radio links that might compromise the end-to-end performance. To overcome these limitations, this paper presents TOPOCBF, a novel contention-based broadcast forwarding protocol that dynamically selects forwarding paths based on their capability to route packets between anchor points. Such capability is estimated by means of a multi-hop connectivity metric. The obtained results demonstrate that TOPOCBF can provide good packet delivery ratios while reducing the communications load compared to unicast sender-based forwarding schemes using road traffic density estimates. 相似文献