Brain activity differentiates face and object processing in 6-month-old infants.

Event-related potentials were used to determine whether infants, like adults, show differences in spatial and temporal characteristics of brain activation during face and object recognition. Three aspects of visual processing were identified: (a) differentiation of face vs. object (P400 at occipital electrode was shorter latency for faces), (b) recognition of familiar identity (Nc, or negative component, at frontotemporal electrodes [FTEs] was of larger amplitude for familiar stimuli), and (c) encoding novelty (slow wave at FTEs was larger for unfamiliar stimuli). The topography of the Nc was influenced by category type: Effects of familiarity were limited to the midline and right anterior temporal electrodes for faces but extended to all temporal electrodes for objects. Results show that infants' experience with specific examples within categories and their general category knowledge influence the neural correlates of visual processing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Earthquakes and children: The role of psychologists with families and communities.

The 2008 Sichuan Province earthquake and 2005 Pakistan earthquake are examples of natural disasters that took an unimaginable toll on children. In such disaster management contexts, family members as well as health care and school personnel are the first-line responders and are natural sources of continued social support as children recover. Although psychologists have increasingly sophisticated understandings of post-disaster reactions and strategies for helping children and adolescents cope with trauma, models for responding to mass catastrophes are limited, particularly in geographically remote communities and in regions in which mental health services are stigmatizing. With children’s well-being subsequent to earthquakes inextricably linked to family and community, psychologists can make important contributions in 3 spheres: (a) coordinating and activating collaborations within children’s existing social contexts to develop post-earthquake interventions; (b) designing prevention and preparedness programs focused on the emotional needs of children in earthquake-prone communities; and (c) conducting research on interventions and recovery with particular attention to developmental stage, sociocultural-economic contexts, and the similarities versus differences across various types of disasters. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Immuno-SEM characterization of developing bovine cartilage

Collagen is a vital material in the tissues of living organisms. Found almost everywhere in the human body, collagen is important in connective tissues, bone growth, and cartilage. Collagen XI makes up a very small portion of the cartilaginous tissue; however, it plays a key role in cartilaginous tissue. Collagen XI and two collagen XI isoforms, V1b and V2, are critical in the ossification process. The location of collagen XI, V1b, V2, and their specific functions in the ossification process within developing bovine cartilage are not well characterized. In this work, the location of collagens I, II, XI and two collagen XI isoforms, V1b and V2, present in developing bovine cartilage are investigated using the immuno-SEM technique. The results for the locations of collagen I and II indicate a high level of consistency with previous work, thus showing that the technique of immuno-SEM can be used with confidence to determine the location of various collagen types within cartilaginous and mineralized tissue. This work has shown that collagen XI is present in the lower hypertrophic region and also in a pericellular arrangement, within about two microns of cell walls, throughout the cartilaginous tissue. V1b is expressed in the articular surface, mineralized region, resting zone, and the distal edge of the diaphysis. The V2 isoform is most strongly expressed in areas of newly forming cartilage, and disappears with chondrocyte maturation. V2 is present in the distal edge of the epiphysis, as well as in mineralized tissue. Collagen XI and two of its isoforms, V1b and V2, are thought to play a critical role in the ossification process. However, this role is not well understood, and is still being characterized. The detection of collagen XI and two of its isoforms in the osteo-chondral junction as well as at a joint surface further point to collagen XI, V1b, and V2 playing a vital role in the ossification process, and warrants further research as to their specific function within the ossification process.     

Civil Engineering Education and Complex Systems

Civil engineering is an interdisciplinary field, and most of the projects designed and built represent very complex systems, both during the construction phase and in the built phase. This research describes how a course in land development that included engineering design elements, lectures that also touched on other related fields, and a field journal assignment at a “green” (sustainable) construction site facilitated students’ understanding of complex systems. Results suggest that this course design facilitates the development of students’ proficiencies in several skill sets, and can increase students’ understanding of the complexity involved in civil engineering projects.     

Drug use and validity of substance use self-reports in veterans seeking help for posttraumatic stress disorder.

The present study assessed drug use and the validity of self–reports of substance use among help–seeking veterans referred to a specialty clinic for the assessment of posttraumatic stress disorder (PTSD). Patients (n?=?341) were asked to provide a urine sample for use in drug screening as part of an evaluation of PTSD. Self–reports of substance use were compared with same–day supervised urine samples for 317 patients who volunteered to participate in a drug screening. Results suggested that self–reports were generally quite valid. Only 8% of the cases involved patients not reporting substance use detected by urine screens. A total of 42% of the participants were identified as using drugs of abuse (excluding alcohol) through self–report and urine drug screens. Among participants using drugs, PTSD diagnosis was significantly associated with greater marijuana and depressant use as compared with stimulant (cocaine and amphetamines) use. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Book reviews

Australian Environmental Policy 2: Studies in Decline and Devolution

Ken Walker and Kate Crowley (eds) UNSW Press, Sydney, 1999 ISBN 0868406732 (paperback) 323 pp.; bibliography and index RRP $35.00

Beyond Meltdown: The Global Battle for Sustained Growth.

Peter Brain. Scribe, Melbourne, 1999 ISBN 0908011369 (paperback) 273 pp.; bibliography and index RRP $26.95

Cities Back from the Edge: New Life for Downtown

Roberta Brandes Gratz with Norman Mintz John Wiley & Sons, New York, 1998 ISBN 0471144177 (hardback) 347 pp.; index RRP $59.95

Evaluation in Planning: Facing the Challenge of Complexity

Nathaniel Lichfield, Angela Barbanente, Dino Bori, Abdul Khakee and Anna. Prat (eds). Kluwer, Dordrecht, 1998. ISBN 0792351770 (hardback). 383 pp.; index. RRP $254.00

Gritty Cities: Images of the Urban

Lyaranette Finch and Chris McConville (eds). Pluto, Sydney, 1999. ISBN 1864030631 (paperback). 250 pp.; bibliography and index. RRP $24.95

Setting the Stage for Systainability: A Citizen's Handbook

Chris Maser, Russ Beaton and Kevin Smith Lewis Publishers, Boca Raton, 1998 ISBN 1574441876 (hardback) 269 pp.; index RRP $47.50

The Australian Metropolis: A Planning History

Stephen Hamnett and Robert Freestone (eds) Allen & Unwin, Sydney, 1999 ISBN 1865080535 (paperback) 229 pp.; index RRP $35.00     

Novel Bacterial Production of Two Different Bioactive Forms of Human Stem-Cell Factor

Human stem-cell factor (hSCF) stimulates the survival, proliferation, and differentiation of hematopoietic cells by binding to the c-Kit receptor. Various applications of hSCF require the efficient and reliable production of hSCF. hSCF exists in three forms: as two membrane-spanning proteins hSCF248 and hSCF229 and truncated soluble N-terminal protein hSCF164. hSCF164 is known to be insoluble when expressed in Escherichia coli cytoplasm, requiring a complex refolding procedure. The activity of hSCF248 has never been studied. Here, we investigated novel production methods for recombinant hSCF164 and hSCF248 without the refolding process. To increase the solubility of hSCF164, maltose-binding protein (MBP) and protein disulfide isomerase b’a’ domain (PDIb’a’) tags were attached to the N-terminus of hSCF164. These fusion proteins were overexpressed in soluble form in the Origami 2(DE3) E. coli strain. These solubilization effects were enhanced at a low temperature. His-hSCF248, the poly-His tagged form of hSCF248, was expressed in a highly soluble form without a solubilization tag protein, which was unexpected because His-hSCF248 contains a transmembrane domain. hSCF164 was purified using affinity and ion-exchange chromatography, and His-hSCF248 was purified by ion-exchange and gel filtration chromatography. The purified proteins stimulated the proliferation of TF-1 cells. Interestingly, the EC₅₀ value of His-hSCF248 was 1 pg/mL, 100-fold lower than 9 ng/mL hSCF164. Additionally, His-hSCF248 decreased the doubling time, increased the proportion of S and G2/M stages in the cell cycle, and increased the c-Myc expression at a 1000-fold lower concentration than hSCF164. In conclusion, His-hSCF248 was expressed in a soluble form in E. coli and had stronger activity than hSCF164. The molecular chaperone, MBP, enabled the soluble overexpression of hSCF164.     

Children's interpretation of generic noun phrases.

Generic utterances (e.g., "Cows say 'moo"') have 2 distinctive semantic properties: (a) Generics are generally true, unlike indefinites (e.g., "Bears live in caves" is generic; "I saw some bears in the cave" is indefinite), and (b) generics need not be true of all category members, unlike universal quantifiers (e.g., all, every, each). This article examined whether preschool children and adults appreciate both these features, using a comprehension task (Study 1) and an elicited production task (Study 2). In both tasks, 4-year-old children--like adults--treated generics as distinct from both indefinites ("some") and universal quantifiers ("all"). In contrast, 3-year-olds did not differentiate among generics, "all," and "some." By 4 years of age, generics emerge as a distinct semantic device. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relationship between behavioral marital therapy outcome and process variables.

This study was conducted to identify therapist and client behaviors with a positive response to social learning-based behavioral marital therapy. A sample of 32 couples receiving treatment was examined. Immediately after each therapy session, the therapist, husband, and wife independently completed process ratings forms that measured therapist and client behaviors during the session. Composite scales, derived from these ratings, were entered into multiple regression equations to examine their relationship with posttherapy marital satisfaction. After controlling for pretherapy marital satisfaction and the other predictor variables, therapists', husbands', and wives' ratings of positive client behavior (i.e., collaboration, active participation, and homework compliance) were positively associated with therapy outcome. Implications for marital therapy and suggestions for future research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)