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991.
992.
993.
M. Oguchi A. Inoue H. Yamaguchi T. Masumoto 《Journal of Materials Science Letters》1991,10(5):289-291
On leave from: Research and Development, Teikoku Piston Ring Co., Ltd. 相似文献
994.
M Kobayashi K Muro K Yoh M Kondoh S Iwabuchi K Hirayama T Ishizu S Kikuchi N Yamaguchi A Koyama 《Canadian Metallurgical Quarterly》1998,13(10):2501-2508
BACKGROUND: There have been no reports on the effect of FK5 06, a new immunosuppressive agent, on experimental membranous glomerulonephritis (MN) induced by an exogenous antigen. Therefore we investigated the effects of FK506 on MN induced by cationized bovine serum albumin (C-BSA) in rats. METHODS: Two weeks after the rats were immunized with 1 mg of C-BSA and Freund's complete adjuvant, they received intravenous injections of 3 mg/kg of C-BSA 3 times weekly for 4 weeks. Rats were divided into four groups: group A (n = 5) received intramuscular injections of 3 mg/kg of FK506 daily for 5 days beginning 2 days before the first immunization; group B (n =4) received 1 mg/kg of FK506 daily for 2 weeks beginning 2 weeks after the first immunization; and group C (n =4) received 1 mg/kg of FK506 daily for 2 weeks beginning 4 weeks after the first immunization. Group D (n = 5) received no FK506 and served as the control group. Rats were sacrificed 8 weeks after the first immunization. RESULTS: Administration of FK506 in the preimmunization stage almost completely suppressed the development of MN in group A. Histological findings in groups B and C were similar to those in group D, the control group. However, urinary protein excretion was significantly lower in group B (24+/-46 mg/day) and C (220+/-44 mg/day) than in group D (330+/-61 mg/day). Expression of intracellular adhesion molecule-1 in glomeruli and the number of leukocyte functioning-associated molecules-1 were significantly decreased in groups A, B, and C compared with the control group. Administration of FK506 was not associated with any significant side-effects or histological abnormalities. The whole-blood trough levels of FK506 in groups B and C were 9.1 ng/ml and 9.2 ng/ml respectively. CONCLUSIONS: The efficacy of FK506 was significantly increased when the drug was administered in the early phase of immunization in this model. The present study suggests that FK506 may be useful in patients with intractable nephrotic syndrome such as MN. 相似文献
995.
H Ikeda T Kimura T Ikegami M Kato A Matsunaga S Yokoyama S Yamaguchi T Ohura K Hayasaka 《Canadian Metallurgical Quarterly》1998,80(4):327-329
We identified three different point mutations in the glutaryl-CoA dehydrogenase (GCDH) gene in two unrelated Japanese patients with glutaric aciduria type I (GA-I). One patient was a homozygote for Arg355His and the other a compound heterozygote for Ser305Leu and Met339Val. Arg355His and Met339Val are mutations hitherto undescribed, and all three mutations are predicted to alter the secondary structure of GCDH. Molecular analysis is useful for definite diagnosis and/or prenatal diagnosis of GA-I. 相似文献
996.
K. Araki M. Kondo H. Uozumi N.J. Ekins-Daukes T. Egami M. Hiramatsu Y. Miyazaki M. Yamaguchi 《Solar Energy Materials & Solar Cells》2006,90(18-19):3320-3326
A new concentrator receiver containing a 7 mm×7 mm 3J concentrator solar cell with a 37.4% peak efficiency was developed. The receiver design includes a homogenizer, heat-handling (epoxy lamination) technologies and a low-resistance soldered connection and can be applied to various concentrator optics, including dish systems. The outdoor efficiency with a combination of a plastic Fresnel lens, made by low-cost injection molding, reached 27% on a hot summer day under 35.0 °C ambient temperature without additional cooling. With this newly developed receiver, mechanical engineers will be able to design their own concentrator module suitable for their environment, using their mechanical knowledge and local industrial resources. A 400X and 7056 cm2 concentrator module was fabricated with 36 concentrator receivers connected in series and the same number of newly developed dome-shaped, non-imaging Fresnel lenses. The power rating was 200 Wp. The peak outdoor efficiency on a clear sky day was 26.8±1.5%. The integrated efficiency over the course of the day was 25.3±1.4%. This is the highest module efficiency that has been achieved using a practical module size and electrical rating. 相似文献
997.
M. Nakamura Y. Fujii M. Yamamoto M. Kinoshita M. Yamaguchi 《Journal of Low Temperature Physics》2002,129(1-2):43-48
The phase separation temperatures of dilute solutions of 4He in liquid 3He in the Fermi-liquid region have been measured by detecting the 4He film formation sensitively. From the obtained solubility curve, the effective mass of 4He atom and the difference in binding energy of 4He in liquid 4He and in liquid 3He are proposed. 相似文献
998.
S Yamaguchi Y Ichikawa K Tanaka T Ishikawa H Masui K Koganei K Eguchi H Ike S Ohki H Shimada 《Canadian Metallurgical Quarterly》1996,23(5):529-533
Four prognostics factors were investigated for colorectal cancer metastases. 1) There were statistically more venous invasions using Victoria blue elastic staining in patients with liver or lymph node metastasis than in those without metastasis. 2) The immunohistochemical expression rate of c-erbB-2 in liver metastasis cases was 27%, which was significantly higher than 3% in no metastasis cases. 3) Sialyl Lewis x (SLex) is related with cell adhesion. SLex positive rates in vessel invasion cancer cells were 71.4% with metastasis and 31.0% without metastasis. 4) Matrilysin is one of MMPs and it was significantly increased with Dukes stage by fluorescence intensity. 相似文献
999.
Akio Kawabata Shingo Hirano Masaru Yoshinaka Ken Hirota Osamu Yamaguchi 《Journal of Materials Science》1996,31(18):4945-4949
In the system ZrO2-CeO2, metastable t-ZrO2 solid solutions containing up to 30 mol% CeO2 crystallize at temperatures of 385–430 °C from amorphous materials prepared by the hydrazine method. Crystalline Ce3ZrO8 solid solutions are formed in as-prepared powders between 30–75 mol % CeO2. The variation of the lattice parameters of both solid solutions is determined as a function of CeO2 content. The value of the lattice parameter of pure Ce3ZrO8 (cubic) is a = 0.5342 nm. Detailed characterization of the Ce3ZrO8 powder has been performed. Crystallite size and particle size are strongly dependent on the heating temperature. Specific surface areas do not drop below 40 m2g–1 until the heating temperature is above 1000°C. 相似文献
1000.
H Yamada B Fredette K Shitara K Hagihara R Miura B Ranscht WB Stallcup Y Yamaguchi 《Canadian Metallurgical Quarterly》1997,17(20):7784-7795
Brevican is a nervous system-specific chondroitin sulfate proteoglycan that belongs to the aggrecan family and is one of the most abundant chondroitin sulfate proteoglycans in adult brain. To gain insights into the role of brevican in brain development, we investigated its spatiotemporal expression, cell surface binding, and effects on neurite outgrowth, using rat cerebellar cortex as a model system. Immunoreactivity of brevican occurs predominantly in the protoplasmic islet in the internal granular layer after the third postnatal week. Immunoelectron microscopy revealed that brevican is localized in close association with the surface of astrocytes that form neuroglial sheaths of cerebellar glomeruli where incoming mossy fibers interact with dendrites and axons from resident neurons. In situ hybridization showed that brevican is synthesized by these astrocytes themselves. In primary cultures of cerebellar astrocytes, brevican is detected on the surface of these cells. Binding assays with exogenously added brevican revealed that primary astrocytes and several immortalized neural cell lines have cell surface binding sites for brevican core protein. These cell surface brevican binding sites recognize the C-terminal portion of the core protein and are independent of cell surface hyaluronan. These results indicate that brevican is synthesized by astrocytes and retained on their surface by an interaction involving its core protein. Purified brevican inhibits neurite outgrowth from cerebellar granule neurons in vitro, an activity that requires chondroitin sulfate chains. We suggest that brevican presented on the surface of neuroglial sheaths may be controlling the infiltration of axons and dendrites into maturing glomeruli. 相似文献