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71.
72.
Díaz B Sánchez-Espinel C Arruebo M Faro J de Miguel E Magadán S Yagüe C Fernández-Pacheco R Ibarra MR Santamaría J González-Fernández A 《Small (Weinheim an der Bergstrasse, Germany)》2008,4(11):2025-2034
Inorganic nanoparticles (NPs) show great potential for medicinal therapy. However, biocompatibility studies are essential to determine if they are safe. Here, five different NPs are compared for their cytotoxicity, internalization, aggregation in medium, and reactive oxygen species (ROS) production, using tumoral and normal human blood cells. Differences depending on the cell type are analyzed, and no direct correlation between ROS production and cell toxicity is found. Results are discussed with the aim of standardizing the procedures for the evaluation of the toxicity. 相似文献
73.
Harm Askes Miguel A. Gutirrez 《International journal for numerical methods in engineering》2006,67(3):400-416
A new formulation of gradient elasticity is derived and implemented. Padé approximations are used to introduce an implicit relation between non‐local strains and displacements. As a result, the finite element interpolation requires only ??0‐continuous (rather than ??1‐continuous) shape functions. The underlying energy functional is presented and it is found that the present formulation is of the mixed type, whereby the non‐local strains act as the primary unknowns and the displacements as the auxiliary unknowns. The implications on the interpolation are studied. Finally, the influence of the additional length scale parameter on the global response is assessed. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
74.
Miguel M. Neves Ole Sigmund Martin P. Bendse 《International journal for numerical methods in engineering》2002,54(6):809-834
The problem of determining highly localized buckling modes in perfectly periodic cellular microstructures of infinite extent is addressed. A double scale asymptotic technique is applied to the linearized stability problem for a periodic structure built from linearly elastic microstructures. The obtained stability condition for the microscale level is then used to establish a comparative analysis between different material distributions in the base cell subjected to the same strain field at the macroscale level. The idea is illustrated by some two‐dimensional finite element examples and used to design materials with optimal elastic properties that are less prone to localized instability in the form of local buckling modes at the scale of the microstructure. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
75.
Márquez-Lucero A Gomez JA Caudillo R Miki-Yoshida M José-Yacaman M 《Small (Weinheim an der Bergstrasse, Germany)》2005,1(6):640-644
A method is introduced to assess the tensile strength of carbon nanofibers, carbon nanotubes (CNTs), and linear chains of carbon atoms (C-chains) obtained from thin amorphous carbon films by electron irradiation. Transmission electron microscopy images show that the nanofibers undergo a radiation-induced necking process, characterized by CNT formation and often followed by the formation of a C-chain. Simulations of the necking process are carried out to determine the tensile stress supported by the nanofiber and CNT neck. 相似文献
76.
77.
Chanana M Correa-Duarte MA Liz-Marzán LM 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(18):2650-2660
Insulin-capped gold nanoparticles (Au@insulin NPs) are highly sensitive towards pH and heavy metals, due to the protein coating. Au@insulin NPs aggregate and disaggregate reversibly with pH and in the presence of various heavy metal ions, which can be monitored through reversible changes in their optical properties. The sensitivity of the NPs towards different metal ions is dissimilar and depends on the coordinative properties of each specific metal ion, its valence number, concentration, and reaction time (kinetics), representing a simple tool for studying fundamental metal-protein interactions. Moreover, Au@insulin NPs are biocompatible and highly stable at high ionic strengths, due to their robust protein coating. 相似文献
78.
Ricardo MONTEIRO Miguel ARA&# JO Raimundo DELGADO M&# rio MARQUES 《Frontiers of Structural and Civil Engineering》2018,12(1):109
The increasing awareness of the general society toward the seismic safety of structures has led to more restrictive performance requirements hence, many times, to the need of using new and more accurate methods of analysis of structures. Among these, nonlinear static procedures are becoming, evermore, the preferred choice of the majority of design codes, as an alternative to complete nonlinear time-history analysis for seismic design and assessment of structures. The many available software tools should therefore be evaluated and well understood, in order to be easily and soundly employed by the practitioners. The study presented herein intends to contribute to this need by providing further insight with respect to the use of commonly employed structural analysis software tools in nonlinear analysis of bridge structures. A comparison between different nonlinear modeling assumptions is presented, together with the comparison with real experimental results. Furthermore, alternative adaptive pushover procedures are proposed and applied to a case study bridge, based on a generic plastic hinge model. The adopted structural analysis program proved to be accurate, yielding reliable estimates, both in terms of local plastic hinge behavior and global structural behavior. 相似文献
79.
Miguel-González Celia García-Díaz Manuel Pereiras Bruno Vigil Miguel Rodríguez de Castro Alejandro 《Journal of Mechanical Science and Technology》2021,35(7):2929-2938
Journal of Mechanical Science and Technology - The present study focuses on the numerical modelling of gas-jet wiping process. Many processes involving liquids are necessary during steel... 相似文献
80.
Miguel A. Otero María del C. Vasallo Olga Verdecia Víctor Fernndez Dionisio Betancourt 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1996,67(1):67-71
A process for the preparation of yeast-derived food additives was developed. The four products obtained, yeast protein concentrate (YPC), cell-wall protein (CWP), semi-pure glucomannan (SPG) and yeast extract, compared well with similar products, present in the current market, with respect to functional properties. YPC and CWP exhibited improved water-holding and oil-binding properties over those of soy-protein isolate (SPI). The emulsifying capacity was very close to that observed in commercial samples. A one-step alkaline extraction enhanced the functional properties of primary yeast glycan to match traditional food hydrocolloid sources. SPG showed oil-binding properties significantly greater than commercial glucomannan. 相似文献