Effects of the 5-HT2 receptor antagonist ritanserin on halothane-induced increase of inositol phosphates in porcine malignant hyperthermia

Recent studies have shown a significant increase of inositol phosphates (IPs) in skeletal muscle during episodes of halothane-induced malignant hyperthermia (MH) in pigs. After treatment with dantrolene and disappearance of MH crisis the IP concentrations returned to basal levels. In order to examine if the increase of IPs during halothane-induced MH may be related to an enhanced IP synthesis in response to activation of 5-HT2 (5-hydroxytryptamine) receptors, the effects of ritanserin, a selective 5-HT2 receptor antagonist, on IP levels were investigated. Biopsies of skeletal muscle of the hindlimbs were obtained in random order and IPs were determined in homozygous MH-susceptible (MHS) and MH-non-susceptible (MHN) swine in the following order: (1) basal, (2) after treatment with ritanserin (2.0 mg/kg), (3) after halothane challenge (3 vol% for 20 min). Basal concentrations of all IPs were higher in MHS than in MHN swine. Ritanserin did not cause any significant changes of IP levels compared to the basal concentrations in MHS and MHN pigs. In MHS pigs, ritanserin did not prevent a halothane-induced MH-crisis. After halothane challenge, 1,3,4-IP3, 1,3,4,6-IP4 and 1,3,4,5-IP4 levels were increased in MHS (during MH crisis) vs. basal concentrations, whereas no changes were found in MHN pigs. Since the increases of IP levels in MHS pigs during MH crisis found in the present study were comparable to those without pretreatment with ritanserin, shown by recent studies, it may be concluded that ritanserin does not prevent the increase of IPs during a halothane-induced MH. Thus, the present data indicate that increases of IP levels during halothane-induced MH in swine are due to other mechanisms than 5-HT mediated enhancement of IP synthesis.     

Beobachtungen über den Einfluß kleiner Zusätze von Cermischmetall auf das Zunderverhalten von Stählen

Observations concerning the influence of small additions of cerium mixed metal on the scaling of steels The addition of appr. 0.1 % cerium mixed metal to steel X 10 CrNi 18 10 has practically no influence on the isothermal oxidation of the steel in air at 800 and 900°C, but improves the adhesion of the scale under temperature cycling conditions. The positive effect of cerium becomes apparent only after extended annealing or after several temperature cycles respectively. In the case of steel 10CrMo9 10 the addition of cerium mixed metal in quantities up to 0.3% has practically no effect. With cerium contents of 0.75%, however, annealing in air at temperatures around 600 °C results in a scale showing excellent adhesion and resisting even quenching in water without spalling. Cerium contents of this level, however, give rise to changes of the mechanical and technological properties of the steel so that their practical use should be out of the question.     

Player behavior and traffic characterization for MMORPGs: a survey

Massively Multiplayer Online Role-Playing Games (MMORPGs) are one of the most exciting and most rapidly expanding genres of online games. This survey presents state-of-the-art and current research efforts in measuring, characterizing, and modeling the player behavior and the network traffic, as well as the relationships between them. We also tabulate the measurement, modeling and analysis results regarding network traffic and player behavior found in literature, with key information regarding each dataset. Finally, we list currently confirmed claims and open research questions in the area of MMORPGs.     

A new method for computing fuzzy functional dependencies in relational database systems

In this paper, we present a new method for computing fuzzy functional dependencies between attributes in fuzzy relational database systems. The method is based on the use of fuzzy implications. A literature analysis has shown that there is no algorithm that would enable the identification of attribute relationships in fuzzy relational schemas. This fact was the motive for development a new methodology in the analysis of fuzzy functional dependencies over a given set of attributes. Solving this, not so new problem, is not only research challenge having theoretical importance, but it also has practical significance. Possible applications of the proposed methodology include GIS, data mining, information retrieval, reducing data redundancy in fuzzy relations through implementation of logical database model, estimation of missing values etc.     

Design,manufacture and geometric verification of rapid prototyped microfluidic encapsulations by computed tomography

This paper presents the dimensional verification of encapsulations used to package microfluidic devices manufactured using a 3D printer of photopolymerisable resin. This characterisation has been performed by computed tomography (CT) by comparing newly manufactured encapsulations and samples that have been subjected to test conditions. Thus, it has been possible to draw conclusions both on the deviations of the nominal geometry of the encapsulations and on how this might affect their performance. This paper presents a scheme of dimensional verification from the point clouds obtained by CT. Finally, a combined threshold and scale factor correction technique of the tomography images is shown. This method is based on the simultaneous measurement of objective and master parts with known geometry. The results reveal the improvements achievable in the accuracy, given a particular machine configuration. The conclusions facilitate the improvement of the geometric design of these devices regarding their behaviour under test conditions.     

Infrastructures for the environment of multiagent systems

The notion of environment is receiving an increasing attention in the development of multiagent applications. This is witnessed by the emergence of a number of infrastructures providing agent designers with useful means to develop the agent environment, and thus to structure an effective multiagent application. In this paper we analyse the role and features of such infrastructures, and survey some relevant examples. We endorse a general viewpoint where the environment of a multiagent system is seen as a set of basic bricks we call environment abstractions, which (i) provide agents with services useful for achieving individual and social goals, and (ii) are supported by some underlying software infrastructure managing their creation and exploitation. Accordingly, we focus the survey on the opportunities that environment infrastructures provide to system designers when developing multiagent applications.     

Improved compressed sensing reconstruction for $$^{19}$$ F magnetic resonance imaging

Magnetic Resonance Materials in Physics, Biology and Medicine - In magnetic resonance imaging (MRI), compressed sensing (CS) enables the reconstruction of undersampled sparse data sets. Thus,...